Clinical trials: Prednisolone, completed
Nasal Polyposis
Comparison of Methylprednisolone or Methotrexate in the Maintenance Treatment of Nasal Polyposis
Chronic rhinosinusitis with nasal polyposis (CRwNP) is an inflammatory disease of the nasal mucosa. It is presented with severe stuffiness, nasal discharge, facial pressure/pain, and sleep disorders.
- Trial name
- NCT04532736
- Testing
- Emthexate, Prednol, Mometasone Furoate
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Dokuz Eylul University
COVID-19 Respiratory Infection, FLU
Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients
The primary objective of this study is to determine the safety and efficacy profile of the food supplement (KUNAMIN®) containing grape juice, seed, stem, and bark given to patients treated with the established treatment regimen…
- Conditions
- COVID-19 Respiratory Infection, FLU, Cold; Influenza, Bacterial Pneumonia
- Trial name
- NCT05417997
- Testing
- Kunamin®, Favipiravir, Enoxaparin
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- RAAS Nutritionals, LLC
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate
In this open-label single arm study the safety and efficacy of Mabthera will be evaluated in patients with active rheumatoid arthritis who have had an inadequate response to methotrexate.
- Trial name
- NCT01000610
- Testing
- rituximab [MabThera/Rituxan], methotrexate, methylprednisolone
- Where
- 4 sites in Tunisia
- Volunteers
- 18 people
- Sponsor
- Hoffmann-La Roche
Kidney Diseases
Steroid Withdrawal in Pediatric Renal Transplant Recipients Under Cyclosporine (CyA) and Mycophenolate Mofetil (MMF)
The present study investigates the safety and efficacy of steroid withdrawal in pediatric renal transplant recipients with stable graft function under concomitant immunosuppression with cyclosporine and mycophenolate mofetil.
- Trial name
- NCT00309218
- Testing
- methylprednisolone
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Klinik für Kinder- und Jugendmedizin
Keratoconus, Unstable, Collagen Crosslinking
Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
There is no standard of care medication regimen for the management of pain and inflammation post-corneal crosslinking (CXL), although most cornea specialists agree on use of an antibiotic and steroid eye drop in the immediate…
- Conditions
- Keratoconus, Unstable, Collagen Crosslinking, Postoperative Pain
- Trial name
- NCT04168112
- Testing
- Dextenza, Prednisolone Acetate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sight Medical Doctors PLLC
Carpal Tunnel Syndrome, Local Steroid Injection
Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome
Carpal tunnel syndrome is caused by the compression of median nerve at the wrist where it passes through a narrow space called carpal tunnel formed by the wrist bones, ligaments and tendons.
- Conditions
- Carpal Tunnel Syndrome, Local Steroid Injection, Wrist Splinting
- Trial name
- NCT02140632
- Testing
- Local methylprednisolone acetate and lidnocaine injection, wrist splinting
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Kwong Wah Hospital
Relapsing-Remitting Multiple Sclerosis
Is IFN-beta Treatment in MS Useful After a Washout Period in Patients With Neutralizing Antibodies to Interferon Beta
This study is to find out if Interferon-beta (IFN-beta) can recover its effectiveness after a washout period in patients with Multiple Sclerosis who have previously developed neutralizing antibodies to Interferon-Beta
- Trial name
- RENeu (NCT00493116)
- Testing
- Interferon-beta-1a, methylprednisolone
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 20 people
- Sponsor
- Biogen
Metastatic Prostate Cancer
One-year, Open Extension to Evaluate the Treatment of Patients With Castration-Resistant Prostate Cancer With YONSA™
This is an open-label, single-arm, multi-center extension study to evaluate safety in patients with mCRPC of YONSA 500 mg (4 x 125 mg qd) with methylprednisolone (4 mg bid).
- Trial name
- NCT02962284
- Testing
- abiraterone acetate with Methylprednisolone
- Volunteers
- 20 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Heart Arrest
Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest
This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of vasopressin and methylprednisolone during adult in-hospital cardiac arrest.
- Trial name
- VAM-IHCA (NCT03640949)
- Testing
- Vasopressin, Arginine, Methylprednisolone, NaCl
- Where
- 10 sites in Denmark
- Volunteers
- 501 people
- Sponsor
- Lars Wiuff Andersen
Rheumatoid Arthritis
IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA
The purpose of the study is to better understand the factors present in the cells of inflamed joints of patients with arthritis that may cause rheumatoid arthritis.
- Trial name
- NCT02451748
- Testing
- Lab Work, Certolizumab pegol (CDP870, tradename Cimzia)(prefilled syringes at the dose of 200mg), Certolizumab pegol (CDP870, tradename Cimzia)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Illinois Chicago
Refractive Surgery
The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral PRK surgery.
- Trial name
- NCT04396990
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Thrombotic Thrombocytopenic Purpura
Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura
This is a single group, treatment, Phase 3, open-label, single-arm study to evaluate the efficacy and safety of caplacizumab and immunosuppressive therapy (IST) without firstline therapeutic plasma exchange (TPE) with primary…
- Trial name
- MAYARI (NCT05468320)
- Testing
- Caplacizumab, Corticosteroids, anti-CD20 antibody
- Where
- 27 sites in United States, Belgium and 9 more
- Volunteers
- 51 people
- Sponsor
- Sanofi
Shoulder Pain
Ultrasound Guided Steroids Injection Versus PRP for Shoulder Pain Relief
Comparison between effects of ultrasound guided platelet rich plasma injection versus steroids injection for pain relief in cases of partial rotator cuff tears
- Trial name
- PRP (NCT05317624)
- Testing
- Platelet rich plasma, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Thyroid Associated Ophthalmopathy, Hypercholesterolemia
Effects of Atorvastatin in Graves' Orbitopathy (GO)
Graves' orbitopathy (GO) is the most common extra-thyroidal manifestation of Graves' disease (GD), being observed in ~25% of patients.
- Trial name
- STAGO (NCT03110848)
- Testing
- Atorvastatin, Methylprednisolone
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University of Pisa
Asthma
Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma
This is a randomised, double-blind, placebo-controlled, parallel-group, multicenter study of mepolizumab in comparison with placebo in reducing Oral Corticosteroid (OCS) use in subjects with severe refractory asthma.
- Trial name
- NCT01691508
- Testing
- Mepolizumab, OCS (prednisone/prednisolone)
- Where
- 47 sites in United States, Australia and 8 more
- Volunteers
- 135 people
- Sponsor
- GlaxoSmithKline
Status Asthmaticus
Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus
This study is a Phase I study to investigate the addition of inhaled Ipratropium bromide to standard therapy in the treatment of severe asthma attacks in children admitted to the Pediatric Intensive Care Unit.
- Trial name
- NCT02872597
- Testing
- Ipratropium, 0.9% Sodium Chloride, Albuterol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Prostate Cancer Metastatic
Early Access to Cabazitaxel in Patients With Metastatic Hormone Refractory Prostate Cancer Previously Treated With a Docetaxel-containing Regimen
The purpose of this study is to allow patients similar to that evaluated in the TROPIC trial (NCT00417079), and Investigators access to cabazitaxel for the management of metastatic Hormone Refractory Prostate Cancer (mHRPC) in…
- Trial name
- NCT01254279
- Testing
- CABAZITAXEL
- Where
- 165 sites in Australia, Austria and 27 more
- Volunteers
- 984 people
- Sponsor
- Sanofi
Lupus Nephritis
Efficacy of Lower Dose Prednisolone in the Induction of Remission of Lupus Nephritis
The LN is a common cause of mortality and morbidity in SLE. The use of high-dose glucocorticoids (GC) with an immunosuppressive agent is usual practice for treating this condition.
- Trial name
- LN (NCT04146220)
- Testing
- Prednisolone
- Where
- Bangladesh
- Volunteers
- 32 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Ofatumumab, High Dose Methylprednisolone, Ofatumumab and Lenalidomide Consolidative Therapy for Untreated CLL/SLL
The main purpose of this study is to see if ofatumumab with methylprednisolone followed by additional treatment with ofatumumab and lenalidomide can help people with Chronic Lymphocytic Leukemia (CLL) get rid of their CLL for a…
- Trial name
- NCT01496976
- Testing
- High Dose Methylprednisolone (HDMP), Ofatumumab, Lenalidomide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pain,, Edema,
Effect of Dexamethasone and Methylprednisolone on Pain, Swelling and Trismus After Third Molar Surgery
The main aim of the present study was to investigate the effect of preemptive dexamethasone and methylprednisolone to prevent pain, swelling and limitation in mouth opening following third molar extraction.
- Conditions
- Pain,, Edema,, Trismus
- Trial name
- NCT01603498
- Testing
- Dexamethasone, Methylprednisolone
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
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