Clinical trials: Prednisolone
Kidney Transplantation, Renal Transplantation
Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation
The purpose of this study was to assess whether a new drug, Nulojix® (belatacept), would minimize serious long term side effects associated with anti-rejection medications while still protecting the new kidney from damage.
- Trial name
- NCT01436305
- Testing
- Alemtuzumab, MMF, Basiliximab
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Frozen Shoulder
Therapeutic Effect of Shoulder Anterior Capsular Block Versus Suprascapular Nerve Block in Patients With Frozen Shoulder
he study will include 50 patients with frozen shoulder with no healthy volunteer , Patients in this study will be randomized into two groups suprascapular nerve block and Shoulder anterior capsular block
- Trial name
- NCT06725823
- Testing
- suprascapular nerve block group, shoulder anterior capsular block group
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Lymphoma, B-Cell
Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma
This is a Phase 1b study consisting of 2 parts: a dose escalation (Part 1) of CC-220 or CC-99282 added to the standard R-CHOP-21 regimen for first-line treatment of a-BCL.
- Trial name
- NCT04884035
- Testing
- CC-220, Rituximab, Cyclophosphamide
- Where
- 36 sites in United States, Australia and 5 more
- Volunteers
- 224 people
- Sponsor
- Celgene
Multiple Sclerosis, Optic Neuritis
Optic Neuritis Treatment Trial (ONTT)
To assess the beneficial and adverse effects of corticosteroid treatment for optic neuritis. To determine the natural history of vision in patients who suffer optic neuritis.
- Trial name
- NCT00000146
- Testing
- Methylprednisolone, Prednisone
- Where
- 15 sites in United States
- Sponsor
- National Eye Institute (NEI)
Chronic Obstructive Pulmonary Disease
Glasgow Supported Self Management Trial (GSuST)
Training patients to alter their own therapy early in the course of a developing exacerbation (self-management) has been shown to improve outcomes in asthma, but there is no good evidence on this for patients with Chronic…
- Trial name
- GSuST (NCT00706303)
- Testing
- Supported self management training and support
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Bell's Palsy
Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China
The aim of this study is to compare the effects of prednisolone and staging acupuncture in the recovery of the affected facial nerve, and to verify that whether in combination with staging acupuncture is more effective than…
- Trial name
- NCT01201642
- Testing
- Prednisolone, acupuncture, other treatment
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Xijing Hospital
Short-term (3 Days) High-dose (1000 mg) Systemic Methylprednisolone
High-dose, Short-term Steroid and Low-dose Long-term Steroid Use in ARDS Caused by COVID-19
In this study, we aimed to compare, retrospectively, the 15-day continuous hemodynamic, laboratory and clinical course of COVID 19 patients to whom we administered short-term (3 days) high-dose (1000 mg) systemic…
- Trial name
- NCT05047874
- Testing
- systemic methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Biruni University
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
A Trial of Selinexor, Ruxolitinib and Methylprednisolone
Selinexor, a first-in-class, oral selective exportin 1 (XPO1) inhibitor, has shown promise in pre-clinical and clinical studies.
- Trial name
- KPT-IST-391 (NCT06225310)
- Testing
- Selinexor, Ruxolitinib, Methylprednisolone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oncotherapeutics
Benign Mucous Membrane Pemphigoid
Clinical Evaluation of New Treatment Strategy of Mucous Membrane Pemphigoid Using Large Dose of Prednisolone Plus Intra-lesional of Triamcinolone Acetonide Followed by Combination of Mycophenolate Mofetil, Dapsone and Low Dose Prednisolone
Abstract: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disorder characterized by inflammation, blistering, and scarring and predominantly occurring at mucous membranes.
- Trial name
- NCT04744623
- Testing
- large dose of prednisolone plus intra-lesional of Triamcinolone Acetonide followed the systemic combination of mycophenolate mofetil (MMF), dapsone and low dose prednisolone in treatment of MMP
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Tanta University
Arthroplasty, Replacement, Knee, Hip
Prospective Randomized Controlled Trial of Impact of Enhanced Recovery After Surgery(ERAS) for Outcomes of Total Knee and Hip Arthroplasty
The purpose of this study is to analyze the effect of the ERAS(early recovery after surgery) protocol on total knee and hip arthroplasty compared to conventional standard protocol.
- Trial name
- NCT03869203
- Testing
- Enhanced recovery after surgery (ERAS)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Diabetes, Healthy
Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients
Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients.
- Trial name
- NCT01420497
- Testing
- intra-articular infiltration, epidural infiltration
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Glomerulonephritis, IgAN
Prevention in Recipients With Primary IgA Nephropathy of Recurrence After Kidney Transplantation: ATG-F Versus Basiliximab as Induction Immunosuppressive Treatment
IgA nephropathy (IgAN) is a histologically defined glomerulonephritis (renal biopsy) by the presence of deposits immunoglobulin A (IgA) in the renal mesangium (at least 1+) by immunofluorescence.
- Trial name
- PIRAT (NCT02523768)
- Testing
- ATG-F, Simulect
- Where
- 15 sites in France
- Volunteers
- 117 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy
Effect of Bevacizumab on Radiation-induced Brain Necrosis in Patients With Nasopharyngeal Carcinoma
Bevacizumab may have a better effect on brain necrosis caused by radiotherapy.This randomized trial aims to investigate whether bevacizumab may alleviate radiation-induced brain necrosis in patients with nasopharyngeal carcinoma.
- Conditions
- Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy, Brain Necrosis
- Trial name
- BRAIN (NCT01621880)
- Testing
- bevacizumab, Corticosteroid
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Kidney Transplantation
Regimen Optimization Study
Patients who undergo a kidney transplant require prolonged therapy with drugs that suppress the immune system (called immunosuppressive regimens) to stop the immune system from attacking the transplanted kidney in order to limit…
- Trial name
- NCT02137239
- Testing
- Thymoglobulin, Belatacept, mycophenolate mofetil(MMF)
- Where
- 20 sites in United States, Argentina
- Volunteers
- 58 people
- Sponsor
- Bristol-Myers Squibb
Inflammation, Bacterial Infections
Sub-Tenon's Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery
The purpose of this study is to compare one intraoperative sub-Tenon's capsule injection of triamcinolone and ciprofloxacin in a biodegradable controlled-release system with conventional prednisolone and ciprofloxacin eye drops…
- Trial name
- NCT00431028
- Testing
- slow delivery ciprofloxacin + triamcinolone
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Federal University of São Paulo
Acute Respiratory Tract Infections
Effects of Nasal-spraying LiveSpo Navax in Treatment of Acute Respiratory Infections in Children
Rationals: Infection with the Respiratory Syncytial Virus (RSV) is one of the most common causes of respiratory tract diseases. However, treatment for pediatric RSV infection remains supportive to prevent co-infection bacteria…
- Trial name
- NCT05164692
- Testing
- LiveSpo Navax, 0.9% NaCl physiological saline
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- National Children's Hospital, Vietnam
SARS-CoV Infection, Severe Acute Respiratory Syndrome (SARS) Pneumonia
Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19
This is a double-blind, randomized, placebo-controlled, phase IIb clinical trial to assess the efficacy of injectable methylprednisolone sodium succinate (MP) in patients with severe acute respiratory syndrome (SARS) in COVID-19…
- Trial name
- MetCOVID (NCT04343729)
- Testing
- Methylprednisolone Sodium Succinate
- Where
- Brazil
- Volunteers
- 416 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Dexamethasone, Hiccup
Methylprednisolone Replacement for Dexamethasone-induced Hiccup
Dexamethasone is a potent synthetic member of the corticosteroid. It is given to cancer patients undergoing chemotherapy to counteract emetic side effect and essential drug for the chemotherapy-treated patients.
- Trial name
- NCT01277731
- Testing
- Methylprednisolone
- Where
- South Korea
- Sponsor
- Gyeongsang National University Hospital
Osteoarthritis
Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES)
The study is a multicenter trial conducted to compare the effectiveness of an injection of a corticosteroid control to mesenchymal stem cell (MSC) preparations from autologous bone marrow concentrate (BMAC), adipose derived stem…
- Trial name
- MILES (NCT03818737)
- Testing
- Bone Marrow Derived MSCs, Adipose-derived MSCs, Umbilical Cord Tissue (UCT) MSCs
- Where
- 5 sites in United States
- Volunteers
- 475 people
- Sponsor
- Emory University
Knee Osteoarthritis
A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
There is an urgent public health need to reduce reliance on opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA).
- Trial name
- SKOAP (NCT04504812)
- Testing
- Duloxetine, Intra-Articular Injection, Nerve Procedure with long acting blocks
- Where
- 24 sites in United States
- Volunteers
- 1,937 people
- Sponsor
- Johns Hopkins University