Clinical trials: Pregabalin, open to volunteers
Pain Postoperative, Osteoarthritis
Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA
The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty.
- Conditions
- Pain Postoperative, Osteoarthritis, Total Knee Arthroplasty
- Trial name
- NCT06328062
- Testing
- Mirogabalin, Pregabalin
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Thammasat University Hospital
Diabetic Pruritus, Efficacy of Pregabalin in Controlling Diabetic Pruritus Severity
Efficacy of Pregabalin for Diabetic Pruritus - A Randomized Controlled Study.
Brief Summary: The goal of this randomized controlled study is to learn if pregabalin combined with emollients can reduce pruritus (itching) in people with Type 2 Diabetes Mellitus.
- Trial name
- PREDICT (NCT06790537)
- Testing
- Pregabalin 75 mg
- Where
- 2 sites in India
- Volunteers
- 46 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Spinal Cord Injuries, Neuropathic Pain
Transcranial Magnetic Stimulation Therapy in Neuropathic Painful Spinal Cord Injury Patients
The aim of our study is to investigate the effect of high-frequency Repetitive Transcranial Magnetic Stimulation(rTMS) therapy applied to the dorsolateral PFC (DLPFC) area on neuropathic pain in patients with spinal cord injury.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Diseases or Conditions
- Trial name
- NCT05645003
- Testing
- High-frequency real-time rTMS protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Fibromyalgia
Effectiveness of Oral Magnesium Supplementation in Fibromyalgia Patients Not Responding to Standard Treatment
Fibromyalgia is a complex widespread pain disorder. OBJECTIVES To evaluate the effectiveness of oral magnesium supplementation in reducing symptom severity among fibromyalgia patients who have not responded to standard treatment…
- Trial name
- NCT07585045
- Testing
- Magnesium glycinate, Vitamins
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Voiding Dysfunction, Substance Abuse
Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction
With the increase of substance abuse over the world, substance abuse e.g. ketamine and methamphetamine related voiding dysfunction is becoming an important medical problem.
- Trial name
- NCT03913819
- Testing
- First line treatment: oral NSAID and anticholinergic agents, Second line treatment: additional treatment for pain control, Third line treatment: A course of intravesical hyaluronate will be given.
- Where
- Hong Kong
- Volunteers
- 1,500 people
- Sponsor
- Chinese University of Hong Kong
Healthy Male and Female Subjects
Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in Chinese Healthy Subject
Y-4 is a new fixed-dose combination drug product containing two active ingredients of pregabalin and riluzole. The objective of the trial is to compare pharmacokinetic characteristics of Y-4 tablets with pregabalin capsules…
- Trial name
- NCT06935721
- Testing
- Y-4 tablet, Pregabalin capsule, Riluzole tablet
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Primary Open - Angle Glaucoma (POAG), Ocular Hypertension (OHT)
A Phase 2a Study Comparing the Efficacy, Safety and Tolerability of Pregabalin Eye Drops Comparing With Timolol Eye Drops in Adults With Glaucoma or High Eye Pressure.
This study is evaluating a new eye drop containing pregabalin (TB0001) as a potential treatment for people with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT07913074
- Testing
- Arm 1: TB0001 ophthalmic solution 0.9%, Arm 2: TB0001 ophthalmic solution 1.2%, TB0001 ophthalmic solution 1.5%
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Tavo Biotherapeutics
Knee Pain Chronic
SMART Embedded Intervention for Military Postsurgical Engagement Readiness
The overarching objective of this proposal is to conduct a multi-site Sequential Multiple Assignment Randomized Trial (SMART) across multiple Military Health System (MHS) sites to optimize the sequencing and integration of two…
- Trial name
- SEMPER (NCT05050409)
- Testing
- Brief mindfulness, Mindfulness-Oriented Recovery Enhancement (MORE), Standard care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Utah
Neuropathic Pain
Crisugabalin for Radiotherapy-Related Neuropathic Pain
The purpose of this study is to evaluate whether Crisugabalin has similar efficacy compared to Pregabalin in reducing radiotherapy-related neuropathic pain (RRNP) in patients with head and neck cancers.
- Trial name
- CRYSTAL (NCT06766916)
- Testing
- Crisugabalin, Pregabalin
- Where
- 11 sites in China
- Volunteers
- 172 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Peripheral Neuropathic Pain
Gabapentin and Pregabalin Effects on Inflammation and Cardiac Function in Peripheral Neuropathic Pain
This prospective, controlled, observational cohort study will evaluate short-term changes in inflammatory biomarkers and subclinical cardiac function in adults with peripheral neuropathic pain who are prescribed gabapentin or…
- Trial name
- NCT07755514
- Testing
- Gabapentin, Pregabalin
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Giresun University
Breast Cancer, Aromatase Inhibitor
Pharmacopuncture for Aromatase Inhibitor Induced Arthralgia (AIA)
This is a pragmatic pilot trial designed to compare and evaluate the efficacy, safety, and cost-effectiveness of pharmacopuncture treatment versus a control group in aromatase inhibitor-induced arthralgia patients with breast…
- Conditions
- Breast Cancer, Aromatase Inhibitor, Aromatase Inhibitor Induced Arthralgia
- Trial name
- P-ATx for AIA (NCT07789717)
- Testing
- pharmacopuncture therapy, Conventional therapy
- Where
- 3 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Ilsan Cha hospital
Coronary Artery Bypass, Anesthesia
Sustainable Anesthesia in Myocardial Revascularization Surgery.
Introduction: Greenhouse gases threaten the health and safety of humanity. The Declaration of Helsinki seeks to protect human health and emphasizes the urgency of implementing sustainable strategies.
- Conditions
- Coronary Artery Bypass, Anesthesia, Sustainability
- Trial name
- NCT07508865
- Testing
- Optimized recovery, Standard Anesthetic Practice
- Where
- Chile
- Volunteers
- 116 people
- Sponsor
- Universidad de La Frontera
Healthy Male and Female Subjects
Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in U.S. Healthy Participants
The primary goal of this clinical trial is to compare pharmacokinetic characteristics of Y-4 tablets with pregabalin capsules and riluzole tablets in the US healthy adult participants after single oral administration under fasted…
- Trial name
- NCT07618715
- Testing
- Y-4 tablet, Pregabalin capsule, Riluzole tablet
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Irritable Bowel Syndrome (IBS)
Efficacy of Pregabalin for Patients With Irritable Bowel Syndrome
To explore the efficacy of pregabalin for patients with irritable bowel syndrome (IBS).
- Trial name
- NCT07635394
- Testing
- The pregabalin group, Routine Treatment
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Beijing Tiantan Hospital
Neuropathic Pain, Insomnia
Sleep and Neuropathic Pain - Intervention Study on Pregabalin
The goal of this clinical study is to study sleep and its microstructure in neuropathic pain patients who have or who do not have a clinically significant sleep disturbance, before and during (after 1-month stabile dosage)…
- Conditions
- Neuropathic Pain, Insomnia, Sleep Disorder
- Trial name
- NCT06155916
- Testing
- Pregabalin
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Helsinki University Central Hospital
Cancer Pain, Orofacial Pain
Effectiveness of Phenotype-based Pain Management Guidelines for Head and Neck Cancer Related Pain: a Pilot Study
The goal of this clinical trial is to find out whether phenotype-based pain management guidelines can effectively and safely reduce head and neck cancer-related pain in adults with head and neck cancer who have not yet started…
- Conditions
- Cancer Pain, Orofacial Pain, Head and Neck Cancer, Head and Neck (HNSCC)
- Trial name
- NCT07919444
- Testing
- myofascial pain, Orofacial bone pain, Orofacial Mucosal Pain
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Diabetic Peripheral Neuropathic Pain
A Study of HRS-2129 in Patients With Diabetic Peripheral Neuropathic Pain
This study aims to investigate the efficacy and safety of HRS-2129 in Chinese diabetic peripheral neuropathic pain (DPNP) in comparison to placebo.
- Trial name
- NCT07377721
- Testing
- HRS-2129 Tablets, Pregabalin Capsules
- Where
- 2 sites in China
- Volunteers
- 168 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Diabetic Neuropathy, Neuropathic Pain
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Neuralgia, Postherpetic
- Trial name
- PRISE (NCT07712913)
- Testing
- Experimental: Pregabalin XR, Comparator: Dorene Tabs
- Where
- 15 sites in Brazil
- Volunteers
- 348 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Postherpetic Neuralgia
Esketamine Combined With PRF of DRG for Postherpetic Neuralgia
This trial's primary objective is to compare the analgesic efficacy of esketamine in combination with pulsed radiofrequency (PRF) of dorsal root ganglion(DRG) against that of PRF monotherapy in patients with postherpetic…
- Trial name
- NCT06914193
- Testing
- esketamine+PRF treatment group, PRF treatment group
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Beijing Tiantan Hospital
Oral, Melatonin
Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
- Conditions
- Oral, Melatonin, Pregabalin, Postoperative Pain
- Trial name
- NCT07344467
- Testing
- Melatonin capsule, Pregabalin capsule
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University