Clinical trials: Propofol, open to volunteers
Airway Obstruction
The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE
The purpose of this study is to investigate the effect of using the McMurray Enhanced Airway (MEA) which is a flexible extended-length distal pharyngeal airway on improving oxygen delivery compared to standard nasal cannula.
- Trial name
- NCT05974488
- Testing
- McMurray Enhanced Airway, Nasal Cannula
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Mannitol Adverse Reaction
Effect of Mannitol on Propofol Level
Group 1 will include 20 patients aged 18 years and over, American Society of Anesthesiologist (ASA) II-III class, who will undergo supratentorial tumor surgery, and Group 2 will include 20 patients who will undergo pituitary…
- Trial name
- level (NCT06884657)
- Testing
- mannitol, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Effect of Drug, Adverse Drug Event
Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation
A multi-center, prospective, randomized, double-blind, active-controlled, no-inferiority clinical trial conducted across 5 tertiary medical centers in China.
- Conditions
- Effect of Drug, Adverse Drug Event, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT06575530
- Testing
- Remimazolam Besylate, Dexmedetomidine Hydrochloride
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Laparoscopic Obstetric Surgery
Total Intravenous Anesthesia (TIVA) Versus Inhalational Anesthesia at The End of Laparoscopic Obstetric Surgery Regarding Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) remain among the most common and distressing complications after general anaesthesia, with important consequences for patient comfort, satisfaction, recovery trajectories, and length of…
- Trial name
- NCT07270289
- Testing
- inhalational anaesthesia, total intravenous anesthesia (TIVA)
- Volunteers
- 98 people
- Sponsor
- Assiut University
Pulmonary Nodule Cm
Sedation of Remazolam Combined With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery
Non-intubated Thoracoscopic surgery (NITS) is a newly emerging minimally invasive surgical technique in recent years . Compared with traditional intubation general anesthesia, it has the advantages of less trauma, faster recovery…
- Trial name
- R-A NITS (NCT06810843)
- Testing
- Remazolam combined with afentanil for non-intubated thoracoscopic surgery, Propofol combined with afentanil in non-intubated thoracoscopic surgery
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Qianfoshan Hospital
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Opioid-Free Anesthesia, POCD
Effect of Opioid-free Anesthesia on Sleep Quality, Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients
Postoperative cognitive dysfunction (POCD)is a common well disorder of the central nervous system after surgery, mainly manifested by impaired memory, spirit, language ability or other aspects of brain function.
- Conditions
- Opioid-Free Anesthesia, POCD, Recovery Quality, Sleep Quality
- Trial name
- NCT06493396
- Testing
- Opioid-free Analgesics, Opioid group
- Volunteers
- 88 people
- Sponsor
- Beijing Friendship Hospital
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro
Lumbar Spinal Stenosis, Lumbar Degenerative Disease
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery
Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Degenerative Disease, Obesity, Intraabdominal Hypertension
- Trial name
- OBESPINE (NCT07688265)
- Testing
- Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA)
- Volunteers
- 90 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Procedural Pain
Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain
Propofol is a commonly used intravenous anesthetic agent, but its administration is frequently associated with injection pain, causing patient discomfort and agitation.
- Trial name
- NCT07422558
- Testing
- Nalbuphine, Lidocaine
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Adenotonsillar Hypertrophy
Remiazolam vs Propofol Total Intravenous Anesthesia on Postoperative Neurodevelopment After General Anesthesia in Children
The goal of this clinical trial is to learn the effects of remimazolam for total intravenous anesthesia on the neurodevelopment of children aged 3-6 years who underwent tonsil/adenoid removal surgery after general anesthesia when…
- Trial name
- REMPPON (NCT07194109)
- Testing
- Remimazolam based total intravenous anesthesia, Propofol based general anesthesia
- Volunteers
- 558 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Out-of-hospital Cardiac Arrest (OHCA)
Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI).
- Trial name
- KETOHCA (NCT06744361)
- Testing
- esketamine hydrochloride, propofol
- Where
- 2 sites in Denmark
- Volunteers
- 282 people
- Sponsor
- Christian Hassager
Anesthesia for Laparoscopic Hysterectomy
Epidural Versus General Anesthesia for Laparoscopic Hysterectomy
This randomized controlled study will compare epidural anesthesia with general anesthesia in women undergoing elective laparoscopic hysterectomy.
- Trial name
- EGA-LH (NCT07847801)
- Testing
- epidural anesthesia, General Anesthesia (GA)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sabiha Başarı
Anesthesia Recovery Period ； Postoperative Pain； Hemodynamic Stability During Surgery
Afentanil and Remifentanil for Anesthesia Quality and Recovery
The goal of this clinical trial is to compare two commonly used opioid pain medications-alfentanil and remifentanil-during general anesthesia for surgery, and to find out whether alfentanil is as good as (not worse than)…
- Trial name
- NCT07761312
- Testing
- alfentanil, Remifentanil
- Volunteers
- 990 people
- Sponsor
- Qianfoshan Hospital
Etomidate, Esketamine
Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children
Objective: To explore the effect of etomidate and esketamine on postoperative pain after tonsillectomy in children. Methods: Investigators enrolled 64 children with American Society of Anesthesiologists (ASA) physical status I…
- Conditions
- Etomidate, Esketamine, Tonsillectomy, Children
- Trial name
- NCT07062601
- Testing
- Etomidate and fentanyl group, Etomidate and esketamine group
- Volunteers
- 64 people
- Sponsor
- Anqing Municipal Hospital
Sedation, Analgesia Assessment
A Prospective Multicenter Registry Study of Sedation and Analgesia in Critically Ill Patients
Sedation and analgesia are essential components of comprehensive care for intensive care unit (ICU) patients, particularly those receiving invasive mechanical ventilation, undergoing invasive procedures, or experiencing pain…
- Conditions
- Sedation, Analgesia Assessment, ICU
- Trial name
- NCT07885930
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Chao Yang Hospital
Obesity, Bariatric Surgery
Opioid-Free Versus Opioid-Based Anesthesia in Bariatric
This study is designed as a prospective, randomized, controlled clinical trial. It will be conducted in the operating rooms of the University of Health Sciences, Diyarbakır Gazi Yaşargil Training and Research Hospital.
- Trial name
- NCT07105839
- Testing
- Intraoperative rescue analgesia, Intraoperative rescue analgesia:
- Volunteers
- 50 people
- Sponsor
- Siirt Training and Research Hospital
Major Depression
Study of Psilocybin Under Anesthesia Controlled by EEG
Major depressive disorder (MDD) affects millions of Americans and remains difficult to treat. Psilocybin, a psychedelic compound, has shown promise for reducing depression symptoms, but a key challenge in psychedelic research is…
- Trial name
- SPACE (NCT07479550)
- Testing
- Psilocybin (Usona Institute), Propofol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University