Clinical trials: Propranolol
Hyperthyroidism
Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy
The overall objective of the HEAT study is to determine the acute effect of propranolol on energy expenditure in patients suffering from hyperthyroidism and to evaluate the consequences of the change of hyper- to euthyroidism on…
- Trial name
- HEAT (NCT03379181)
- Testing
- Propranolol
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastric or Gastroesophageal Junction Adenocarcinoma, Propranolol
Neoadjuvant Propranolol Plus SOX and Toripalimab for Locally Advanced Gastric/GEJ Adenocarcinoma
This is a single-center, prospective, open-label, single-arm, phase Ib/II study evaluating the safety and efficacy of neoadjuvant propranolol combined with SOX chemotherapy and toripalimab in patients with resectable locally…
- Conditions
- Gastric or Gastroesophageal Junction Adenocarcinoma, Propranolol, SOX Chemotherapy, Toripalimab
- Trial name
- NCT07727993
- Testing
- propranolol, Toripalimab, Oxaliplatin
- Volunteers
- 49 people
- Sponsor
- Ting Liu
Burns
Assessment of the Treatment of Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation
The purpose of the program is to study and characterize the outcome of burn injury with particular attention to improving the rehabilitation of burn survivors, including children.
- Trial name
- NCT00675714
- Testing
- Stable Isotope Infusion Study, Collection of blood and tissues, Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
- Where
- United States
- Volunteers
- 1,126 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 1 Diabetes Mellitus
Propranolol in Treating Hypoglycemia Unawareness
Impaired awareness of hypoglycemia is common in type 1 diabetes (T1DM) patients. Impaired hypoglycemia awareness increases severe hypoglycemia risk by six-fold.
- Trial name
- NCT03161964
- Testing
- Propranolol 80 Mg Oral Capsule, Extended Release
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anu Sharma
Hemangioendothelioma of Liver
Sirolimus in the Treatment for Infantile Hepatic Hemangioendothelioma(IEEH)
Infantile hepatic hemangioendothelioma (IHHE) is an infantile hemangioma involving the liver.Since 2008, propranolol has been used for the treatment of hemangioma, and some researchers have also started to report the use of…
- Trial name
- PRL-SRL-IHHE (NCT04406870)
- Testing
- Sirolimus Oral Product, propranolol
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Children's Medical Center
Fear of Spiders, Acute Stress Reaction
The Effects of Propranolol and Hydrocortisone on Military-Relevant Performance Outcomes
This clinical trial aims to evaluate the nature and duration of effects of three FDA-approved medications (propranolol and hydrocortisone) on military-relevant cognitive, emotional, and motor performance following an exposure to…
- Trial name
- NCT06982183
- Testing
- Propranolol, Hydrocortisone
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
CIRRHOSIS, ESOPHAGEAL VARICES
PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES?
This prospective randomized controlled trial will compare endoscopic band ligation (EBL) with propranolol and EBL alone in primary prophylaxis of variceal bleeding among cirrhotic patients with high-risk varices.
- Trial name
- NCT01893541
- Testing
- ENDOSCOPIC BAND LIGATION, PROPRANOLOL, a multiband ligation device
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Soft Tissue Sarcoma
Propranolol Plus Standard Radiation Therapy Before Surgery for the Treatment of Patients With Soft Tissue Sarcoma
This phase I trial tests the safety, tolerability and impact of adding propranolol to standard radiation therapy (RT) before surgery for the treatment of patients with soft tissue sarcoma.
- Trial name
- NCT06670976
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Infantile Hemangioma
Nadolol Versus Propranolol in Children With Infantile Hemangiomas
The purpose of this study is to assess the efficacy and safety of oral propranolol versus nadolol in patients with Infantile Hemangiomas (IH) in a randomized, controlled, double-blinded study.
- Trial name
- NCT02505971
- Testing
- Nadolol, Propranolol
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- The Hospital for Sick Children
Migraine
Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis.
The goal of this clinical trial is to compare efficacy and observe common adverse effects of a combination of amitriptyline-propranolol and pizotifen as prophylactic treatments for migraine.
- Trial name
- NCT06158230
- Testing
- Pizotifen, Amitriptyline-propranolol
- Where
- Bangladesh
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
PTSD
Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol
By age 18, roughly 8% of traumatized youth have met criteria for a diagnosis of PTSD, with numbers rising up to 40% in cases of sexual abuse and assault.
- Trial name
- PPP (NCT04985344)
- Testing
- Propranolol Oral Product, memory reactivation
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Toulouse
Schizophrenia, Schizoaffective Disorder
CLOZAPINE Response in Biotype-1
The CLOZAPINE study is designed as a multisite study across 5 sites and is a clinical trial, involving human participants who are prospectively assigned to an intervention.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar 1 Disorder
- Trial name
- NCT04580134
- Testing
- clozapine, risperidone
- Where
- 5 sites in United States
- Volunteers
- 524 people
- Sponsor
- University of Texas Southwestern Medical Center
Cirrhosis
Impact of Propranolol on the Prognosis of Patients With Decompensated Cirrhosis and MELD Score > 9
Non selective beta blockers (NSBBs), such as propranolol and nadolol, are mainstay therapies for portal hypertension in cirrhosis, but their efficacy and safety vary depending on the stage of the disease.
- Trial name
- NCT07652203
- Testing
- conventional therapy, propranolol
- Where
- China
- Volunteers
- 466 people
- Sponsor
- General Hospital of Shenyang Military Region
Burns, Pain
Burn Healing and Analgesia With Propranolol
The purpose of this study is to investigate the ability of propranolol to decrease pain and improve recovery in burn patients with a common genotype.
- Trial name
- BURN HELP (NCT00934947)
- Testing
- Propranolol, Propanolol
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Chapel Hill
Mean Arterial Pressure
Low Dose Magnesium Sulphate
This clinical trial aims to compare Patients who receive propranolol 1-2 mg to Patients who receive propranolol 1-2 mg in addition to magnesium sulphate infusion 10 mg/kg to see if IV magnesium can stability mean arterial blood…
- Trial name
- NCT06621004
- Testing
- Patients will receive propranolol 1-2 mg., Patient receives magnesium sulphate
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Prostate Cancer
Perioperative Propranolol During Prostatectomy to Decrease Cancer Recurrence
The purpose of this study is to assess the feasibility of conducting a larger randomized controlled trial to assess the efficacy of perioperative propranolol capsules compared with placebo capsules in decreasing recurrence of…
- Trial name
- PeP-RALP (NCT05679193)
- Testing
- Propranolol
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Angiosarcoma
Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Trial by the French Sarcoma Group (GSF/GETO)
Adrenergic processes stimulated by epinephrine and norepinephrine drive to the development of tumor growth and metastasis. Beta-adrenergic receptor (BAR) antagonists have shown efficacy against melanoma, breast cancer and…
- Trial name
- PROPAN (NCT02732678)
- Testing
- PROPRANOLOL
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Migraine Without Aura, Migraine With Aura
Candesartan Versus Propranolol for Migraine Prevention
The main aim of the present study is to compare candesartan with propranolol for migraine prophylaxis.
- Conditions
- Migraine Without Aura, Migraine With Aura, Chronic Migraine
- Trial name
- NCT00884663
- Testing
- Candesartan, propranolol
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- Norwegian University of Science and Technology
Infantile Hemangiomas
Ontogeny of Infantile Hemangiomas With Skin Imaging Modalities
A combined set of quantitative skin imaging methods will quantitatively describe the natural ontogeny and the response to standard treatments over time in patients with infantile hemangiomas.
- Trial name
- NCT02061735
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury
Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon
Traumatic Brain Injury (TBI) is one of the leading causes of death. Severe TBT is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming.
- Trial name
- NCT03401515
- Testing
- Propranolol Hydrochloride 1 MG/ML, Normal saline
- Volunteers
- 60 people
- Sponsor
- Ain Shams University