Clinical trials: Propranolol, open to volunteers
Migraine Associated Vertigo, Tinnitus
Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM)
Many people with migraine also experience tinnitus - a persistent ringing, buzzing, or hissing in the ears - and research suggests these conditions share underlying biological mechanisms, including a protein called calcitonin…
- Conditions
- Migraine Associated Vertigo, Tinnitus, Migraine, Vestibular Migraine
- Trial name
- COMPACT-PM (NCT07655440)
- Testing
- Galcanezumab, Erenumab 70 mg, Eptinezumab
- Volunteers
- 120 people
- Sponsor
- Stanford University
Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes
Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes
Objectives: The primary objective is to assess the safety and tolerability of medical drugs with the potential to enhance performance (PES) in professional athletes over a 5.5 year period, encompassing a 25-week PES Exposure…
- Trial name
- ASCEND001 (NCT07568574)
- Testing
- Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Enhanced Emirates Limited
Migraine
Comparative Efficacy of Flunarizine and Propanolol in Pediatric Migraine
Flunarizine and propranolol have demonstrated efficacy in reducing migraine frequency across age groups, though evidence in pediatric populations remains limited and inconsistent.
- Trial name
- NCT07354126
- Testing
- Flunarizine, Propranolol
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Muhammad Aamir Latif
Menopause
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular…
- Trial name
- NCT06787066
- Testing
- Propranolol Hydrochloride, Phentolamine Injection
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Migraine, Nutraceuticals
Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine
Migraine is a common disabling neurological condition that significantly affects quality of life. While traditional prophylactic treatments (e.g., beta-blockers, antiepileptics) are effective, they may be associated with side…
- Trial name
- NCT07147972
- Testing
- Propranolol 80 mg, Magnesium 400Mg
- Volunteers
- 100 people
- Sponsor
- Fayoum University
Heart Failure, Heart Failure, Diastolic
A Preliminary Study for INFORMED
Investigators will determine whether N-of-1 trials, as a pragmatic, participant-centered approach to medication optimization that can overcome key barriers of deprescribing, can lead to increased participant confidence regarding…
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- PRE-INFORMED (NCT05585125)
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Weill Medical College of Cornell University
TBI Traumatic Brain Injury
Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury
Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors.
- Trial name
- NCT06836856
- Testing
- control, propranolol, Carvedilol
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Tetralogy of Fallot, Double Outlet Right Ventricle
Beta-blocker Administration for Cardiomyocyte Division
Heart failure is a common long-term complication in patients with congenital heart disease (CHD). Medical treatments to promote regeneration of new healthy heart muscle cells have the potential to provide new heart failure…
- Trial name
- NCT04713657
- Testing
- N-thymidine, Urine Collection, Echocardiogram
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Post-Traumatic Stress Disorder, PTSD
Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol
Post-traumatic stress disorder (PTSD) develops after life-threatening events, with domestic violence and sexual assault being major risk factors.
- Trial name
- VIOFEM (NCT07792122)
- Testing
- Propranolol, Psychotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Resectable Non-Small-Cell Lung Cancer
Propranolol Hydrochloride Combined With Toripalimab and Platinum-based Chemotherapy in Resectable Non-Small Cell Lung Cancer
This is a prospective, multicenter, open-label study designed to evaluate the safety and tolerability of propranolol hydrochloride in combination with toripalimab and platinum-based chemotherapy as perioperative treatment in…
- Trial name
- NeoBRIO (NCT07886229)
- Testing
- Propranolol Hydrochloride, Toripalimab, Chemotherapy
- Where
- 4 sites in China
- Volunteers
- 9 people
- Sponsor
- Second Xiangya Hospital of Central South University
Misophonia, Propanolol
Propranolol for Misophonia
The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia.
- Conditions
- Misophonia, Propanolol, Misophonia Treatment
- Trial name
- NCT07271485
- Testing
- propranolol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bloom Mental Health, LLC
Gastric or Gastroesophageal Junction Adenocarcinoma, Propranolol
Neoadjuvant Propranolol Plus SOX and Toripalimab for Locally Advanced Gastric/GEJ Adenocarcinoma
This is a single-center, prospective, open-label, single-arm, phase Ib/II study evaluating the safety and efficacy of neoadjuvant propranolol combined with SOX chemotherapy and toripalimab in patients with resectable locally…
- Conditions
- Gastric or Gastroesophageal Junction Adenocarcinoma, Propranolol, SOX Chemotherapy, Toripalimab
- Trial name
- NCT07727993
- Testing
- propranolol, Toripalimab, Oxaliplatin
- Volunteers
- 49 people
- Sponsor
- Ting Liu
Migraine
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and…
- Trial name
- NCT06972056
- Testing
- Atogepant 60 mg, Propranolol 160 mg, Topiramate 100 mg
- Where
- 37 sites in United States
- Volunteers
- 1,335 people
- Sponsor
- Mayo Clinic
Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Adenocarcinoma AJCC v8
Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma
This phase II trial tests what effects the addition of propranolol to pembrolizumab and standard chemotherapy (mFOLFOX) may have on response to treatment in patients with esophageal or gastroesophageal junction cancer that cannot…
- Conditions
- Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT05651594
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Roswell Park Cancer Institute
PTSD
Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol
By age 18, roughly 8% of traumatized youth have met criteria for a diagnosis of PTSD, with numbers rising up to 40% in cases of sexual abuse and assault.
- Trial name
- PPP (NCT04985344)
- Testing
- Propranolol Oral Product, memory reactivation
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Toulouse
Advanced Melanoma
Naltrexone and Propranolol Combined With Immunotherapy
Various forms of stress can promote cancer development and growth and negatively impact the immune system's response to tumors. Beta-adrenergic and opioid receptors co-exist in many cells including immune cells and are integral…
- Trial name
- NCT05968690
- Testing
- Propranolol, Naltrexone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Sarah Weiss
Small Cell Lung Cancer (SCLC)
Propranolol Hydrochloride Combined With Adebrelimab and Platinum-Based Chemotherapy in Small Cell Lung Cancer
This is a prospective multicenter, open-label, Phase I clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of propranolol hydrochloride in combination with adebrelimab and platinum-based…
- Trial name
- BRIO-SCLC (NCT07886047)
- Testing
- Propranolol Hydrochloride, Adebrelimab, Chemotherapy
- Where
- 4 sites in China
- Volunteers
- 18 people
- Sponsor
- Second Xiangya Hospital of Central South University
Colorectal Neoplasms
Colorectal Metastasis Prevention International Trial 2
The short perioperative period (days to weeks around surgery) is characterized by stress-inflammatory responses, including catecholamines (CAs, e.g., adrenaline) and prostaglandins (PGs, e.g., prostaglandin-E2) release, and…
- Trial name
- COMPIT-2 (NCT03919461)
- Testing
- Propranolol and etodolac
- Where
- 6 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Propranolol, Labour Induction
Effects of Oral Propranolol on Induction-Delivery Interval During Induction of Labour With Oxytocin
Prolonged pregnancy could lead to perinatal and maternal complications. Oxytocin has been wildly used for induction of labour, but prolonged labour continued to occur with its attendant sequelae.
- Trial name
- NCT06960850
- Testing
- Propranolol
- Where
- Nigeria
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Liver Cirrhosis, Portal Hypertension
Underdilated VCX-TIPS Versus EVL Plus NSBB for Secondary Prophylaxis of Variceal Bleeding in Cirrhosis
Variceal bleeding is a major complication of portal hypertension in patients with cirrhosis and is associated with substantial risks of rebleeding and death.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Gastroesophageal Varices Bleeding, Esophageal Varices
- Trial name
- U-TIPS (NCT07587671)
- Testing
- Underdilated VCX-TIPS, Endoscopic Variceal Ligation, Nonselective Beta-Blockers
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- West China Hospital