Clinical trials: Propranolol
Primary Lymphedema
Propranolol Dose Escalation in Lymphedema in Patients
This is a study to investigate the safety and efficacy of propranolol in the treatment of patients with primary lymphedema. The primary goal is to assess patient tolerability of increasing doses of propranolol.
- Trial name
- NCT02595996
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cervical Cancer
Feasibility - Beta Adrenergic Blockade (BB) in Cervical Cancer (CX)
The goal of this clinical research study is to learn how many patients with advanced, recurrent, incurable cervical cancer will complete questionnaires about symptoms, any anxiety, depression, and/or pain, and the quality of…
- Trial name
- NCT01902966
- Testing
- Propranolol, Diary, Relaxation Audio Recording
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Pulmonary Disease, Chronic Obstructive
A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers
Study will investigate the pharmacodynamics of a dual pharmacophore in which a combination of GSK961081 and Propanolol is used to give a total effect of bronchodilation.
- Trial name
- NCT00687700
- Testing
- GSK961081, Propranolol
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Postoperative Pain
Genetic Predictors of Analgesic Efficacy of Propranolol for Treating Postoperative Pain
This study is a randomized, double-blind, placebo controlled clinical trial. The main purpose of this study is to determine if postsurgical pain ratings are improved with treatment with oral Propranolol, and if the effectiveness…
- Trial name
- PRO_GENE_POP (NCT02511483)
- Testing
- Propranolol PO, IV-PCA morphine, Quantitative Sensory Testing (QST)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Locally Advanced Malignant Neoplasm, Breast Cancer
Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
This study is being conducted in patients with newly diagnosed breast cancer that will be undergoing chemotherapy prior to surgery - neoadjuvant chemotherapy.
- Trial name
- NCT01847001
- Testing
- Propranolol, DOT imaging, Paclitaxel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Portal Hypertension, Variceal Rebleeding
HVPG-guided Laparoscopic Versus Endoscopic Therapy for Variceal Rebleeding in Portal Hypertension: A Multicenter Randomized Controlled Trial (CHESS1803)
The development of portal hypertension is a vital event in the natural progression of cirrhosis and is associated with severe complications including gastroesophageal varices bleeding.
- Trial name
- NCT03783065
- Testing
- Propranolol, Laparoscopic splenectomy and pericardial devascularization, Endoscopic therapy
- Where
- 4 sites in China
- Volunteers
- 40 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Trauma and Stressor Related Disorders, Post Traumatic Stress Disorder
Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma
The investigators propose to examine a mismatch-based method of reconsolidation blockade for the treatment of psychological trauma in military personnel and Federal police officers.
- Conditions
- Trauma and Stressor Related Disorders, Post Traumatic Stress Disorder, Acute Stress Disorder, Adjustment Disorders
- Trial name
- NCT04982211
- Testing
- Propranolol
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Douglas Mental Health University Institute
Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders
Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Police officers, correctional service officers, and 911-operators are at increased risk for suffering from trauma-related disorders due to their direct and indirect exposure to life-threatening events, such as shootings, violent…
- Conditions
- Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders, Adjustment Disorders, Acute Stress Disorder
- Trial name
- NCT03152175
- Testing
- Propranolol Hydrochloride
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Douglas Mental Health University Institute
Multiple Myeloma
Study of Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in HCT Recipients
This is a randomized controlled pilot study designed to evaluate whether the beta-adrenergic antagonist propranolol is effective in decreasing gene expression of stress-mediated beta-adrenergic pathways among a cohort of…
- Trial name
- NCT02420223
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical College of Wisconsin
Autonomic Nervous System Diseases, Orthostatic Hypotension
The Pathophysiology of Orthostatic Hypotension
The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system.
- Conditions
- Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
- Trial name
- NCT00748059
- Testing
- Standing or upright tilt, Microneurography, QSweat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension, COVID
ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, enters type II pneumocytes using angiotensin-converting enzyme 2 (ACE2).
- Trial name
- NCT04467931
- Testing
- ACEI/ARB, Non-ACEI/ARB, ACEI
- Where
- United States
- Volunteers
- 22,213 people
- Sponsor
- University of Utah
Healthy
A Study of Continuous Heart Rate Monitoring in Healthy Participants
The main purpose of this study in healthy participants is to find out whether a heart rate monitor will accurately pick up changes in heart rate caused by 2 different medications (pseudoephedrine and metoprolol), on the…
- Trial name
- NCT04682184
- Testing
- Propranolol, Pseudoephedrine, Wearable Biosensor Patch Device
- Where
- Singapore
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hypertension Secondary to Kidney Transplant
Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients
The proposed study investigated the effect of chronotherapeutic alteration of anti-hypertensive medication on nocturnal hypertension and end-organ injury in pediatric renal transplant recipients who are non-dippers.
- Trial name
- NCT01007994
- Testing
- New Medication: Enalapril, Isradipine, Propranolol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Northwell Health
Traumatic Brain Injury
Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury
evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury
- Trial name
- NCT04833218
- Testing
- Propranolol
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Extrusion of Tooth
Oral Propranolol for Reducing Pediatric Dental Patients Anxiety
Evaluating anxiety, heart rate and behavior during dental extractions after oral dose of either Propranolol, Midazolam or a combination of both in uncooperative pediatric patients.
- Trial name
- NCT03388957
- Testing
- Propranolol, Midazolam
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Portal Hypertension, Biliary Atresia
Primary Prophylaxis for Variceal Bleed in Biliary Atresia
Biliary atresia is the commonest etiology of neonatal cholestasis and is the most common indication for pediatric liver transplantation world-wide.
- Trial name
- BA-BB (NCT04494763)
- Testing
- Propanolol
- Where
- India
- Volunteers
- 92 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Insulin Sensitivity, Obesity
The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans
Recent findings document the presence of active brown adipose tissue (BAT) in humans. Cold exposure via adrenergic stimulation activates BAT, which combusts significant amounts of blood glucose and free fatty acid (FFA) to…
- Trial name
- NCT01791114
- Testing
- Cold exposure, Cold exposure plus propranolol, Thermoneutral Conditions
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Lumbar Disc Disease, Spinal Fusion
Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery
The purpose of this study is to determine if treatment with low-dose oral propranolol in the days before and after surgery decrease postoperative pain and improve pain scores.
- Conditions
- Lumbar Disc Disease, Spinal Fusion, Degenerative Disc Disease
- Trial name
- NCT04421209
- Testing
- Propranolol Hcl 40mg Tab
- Where
- United States
- Sponsor
- Duke University
Beta Blocker Toxicity
Clinical Study Evaluating Beta Blockers Use and Fracture Risk in Patients With Primary Osteoporosis
Clinical study evaluating selective or nonselective beta blockers use and fracture risk in patients with primary osteoporosis
- Trial name
- NCT04704947
- Testing
- nonselective beta blocker, cardio-selective beta blocker group, alendronate sodium
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sherief Abd-Elsalam
Infantile Hemangioma
''Efficacy of Propranolol in the Treatment of Infantile Hemangioma"
''Evaluation of the Efficacy of Propranolol in the Treatment of Infantile Hemangioma"
- Trial name
- NCT04684667
- Testing
- Propranolol Therapy for Infantile Hemangioma
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University