Clinical trials: Remifentanil
Remimazolam
The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients
This study prospectively uses the biased coin technique to investigate the effect of concomitant administration of remifentanil on the 95% effective dose of intravenous remimazolam (Effective dose 95 [ED95]) required for loss of…
- Trial name
- NCT05434494
- Testing
- Remimazolam, remifantanil
- Volunteers
- 80 people
- Sponsor
- Ajou University School of Medicine
Measure of Nociception
Composite Variability Index and Propofol Remifentanil Anesthesia
The purpose of the study is to determine if the new Composite Variability Index (CVI) is capable of detecting changing effect compartment concentrations of remifentanil.
- Trial name
- NCT01234194
- Testing
- rising remifentanil concentrations, falling remifentanil concentrations
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bonn
Delirium, Anesthesia
Incidence of Postoperative Delirium in Cancer Patients After Laparoscopic Surgery in Trendelenburg Position
Postoperative delirium is an acute mental syndrome that is caused by diffuse cerebral dysfunction resulting from the action of predisposing and precipitating factors acting together.
- Trial name
- NCT03572517
- Testing
- Subarachnoid block, Spinal morphine
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- AC Camargo Cancer Center
Haemodynamic Fluctuations During Off-pump CABG.
Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil
Induction of general anaesthesia with a combination of opiates and hypnotics often induces vasodilation resulting in several haemodynamic effects such as a decrease in blood pressure (MAP), heart rate (HR) and cardiac output…
- Trial name
- NCT01871935
- Testing
- Remifentanil, Sufentanil
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- University Medical Center Groningen
Hypothermia
Remifentanil and Propofol Versus Fentanyl and Midazolam for Sedation During Therapeutic Hypothermia. A Randomised, Controlled Trial
The aim of this study is to increase knowledge about drug properties and effects during therapeutic hypothermia. The primary end point of this study is the time from termination of sedation to extubation in patients treated with…
- Trial name
- Cool Sedation (NCT00667043)
- Testing
- remifentanil and propofol, fentanyl and midazolam
- Where
- 2 sites in Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Craniotomy, Seizures
Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Awake craniotomy require a cooperative patient during resection neurosurgery phase. Anesthesiologist should guarantee analgesia, sedation, nausea and vomiting prevention, while maintaining normal vital parameters.
- Conditions
- Craniotomy, Seizures, Dexmedetomidine, Propofol
- Trial name
- NCT05103735
- Testing
- Propofol
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Hip Arthroplasty
Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.
- Trial name
- NCT03173339
- Testing
- Endotracheal intubation using laryngoscope, High remifentanil, Low remifentanil
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Keimyung University Dongsan Medical Center
Nociception During Anesthesia in Patients Taking β1-adrenergic Antagonist Chronic Treatment
Impact of Chronic Treatment by β1-adrenergic Antagonists on Nociceptive-Level (NOL) Index Variation After a Standardized Noxious Stimulus Under General Anesthesia
The aim of the present study is to investigate the effect of chronic treatment with β1-adrenergic antagonist on the NOL index variation, the heart rate variation and the mean blood pressure variation after a standardized noxious…
- Trial name
- BetaNOL (NCT04060095)
- Testing
- standardized noxious stimulus under general anesthesia.
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Sedative Overdose
Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses
Background: The mechanisms of action of intravenous anesthetics are unclear and the current monitors have limitations. This signifies difficulties when assessing the correct dosage due to the considerable inter-individual…
- Trial name
- NCT03928366
- Testing
- Propofol, Remifentanil
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Other Specified Injuries of Vocal Cord, Sequela
Laryngeal Injuries After Anesthesia Induction With Three Different Sevoflurane Concentrations (Without Muscle Relaxant)
Anesthesia induction and tracheal intubation can be performed with and without neuromuscular blocking agents (NMBAs). Tracheal intubation can be performed with sevoflurane instead of NMBAs; intubating conditions are similar and…
- Trial name
- SEVODosage (NCT01896245)
- Testing
- sevoflurane 1,0, sevoflurane 1,2, sevoflurane 1,4
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University of Rostock
Consciousness Disorder
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials
- Trial name
- NCT05823454
- Testing
- Different drug dosage
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Anterior Cerebral Circulation
Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.
- Conditions
- Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia, Procedural Sedation
- Trial name
- AMETIS 2 (NCT07235514)
- Testing
- General Anesthesia, Procedural sedation
- Where
- 16 sites in France
- Volunteers
- 958 people
- Sponsor
- University Hospital, Clermont-Ferrand
Nodular Goiter
Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy
Extensive clinical studies have shown that intraoperative infusion high dose of remifentanil (0.2ug/kg/min) induced postoperative hyperalgesia.
- Trial name
- NCT01761149
- Testing
- Remifentanil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Central South University
Optic Nerve Sheath
The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD)…
- Trial name
- NCT02003768
- Testing
- Propofol, Desflurane
- Sponsor
- Yonsei University
Anesthesia
Bispectral Index Under Propofol Anesthesia in Children : a Study Between TIVA and TCI
In children, only a few studies have compared different modes of propofol infusion during a total intravenous anesthesia (TIVA) with propofol and remifentanil.
- Trial name
- NCT02637726
- Testing
- Propofol : TCI Schnider, Propofol : TCI Kataria, Propofol : TIVA
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Pr Isabelle CONSTANT
Postoperative Pain
Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia
Fast awakening from anesthesia is one of the major characteristics of remifentanil-associated anesthetic induction and maintenance, whereas corresponding pain during awakening influences patient's rehabilitation strongly.
- Trial name
- CARAN (NCT00738192)
- Testing
- Fentanyl citrate, Sufentanil citrate, Butorphanol tartrate
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanjing Medical University
Analgesia, ICU Patients Requiring Invasive Mechanical Ventilation
Clinical Study on the Efficacy and Safety of Hydromorphone for ICU Analgesia
This study is a prospective, single-center clinical study to evaluate the advantages, extensibility and safety of hydromorphone as an analgesic drug in ICU, and to compare it with remifentanil, a traditional sedative drug.
- Trial name
- NCT06848452
- Testing
- no-intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Affiliated Hospital of Nantong University
Hemodynamic Instability
Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery
During endoscopic sinus surgery (ESS), epinephrine local injection and controlled hypotension is essential in order to increase the visibility in the operative field and reduce the risk.
- Trial name
- NCT02464722
- Testing
- Dexmedetomidine, Remifentanil, Epinephrine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Postoperative Delirium
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anesthesia (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
- Trial name
- NCT06115031
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 696 people
- Sponsor
- Samsung Medical Center
Lung Cancer, Lung; Node
Remifentanil Target Controlled Infusion Versus Standard of Care for Conscious Sedation During EBUS-TBNA
Background: endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure for diagnosing and staging mediastinal lymph node lesions in lung cancer.
- Conditions
- Lung Cancer, Lung; Node, Sedation Complication, Endoscopy
- Trial name
- NCT06033729
- Testing
- Remifentanil TCI, Midazolam injection, Fentanyl
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Scarlata, Simone, M.D.