Clinical trials: Rifampin
Healthy Volunteers
Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort
The primary objective of the study is to determine the potential effects of multiple doses of rifampin and clarithromycin on the single dose pharmacokinetics (PK) of the deflazacort active metabolite (21 desacetyl-DFZ) in healthy…
- Trial name
- NCT02286635
- Testing
- Deflazacort and rifampin, Deflazacort and Clarithromycin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- PTC Therapeutics
Endometriosis
Drug-drug Interaction Study Between Orally Administered Rifampicin and Vilaprisan
This study will be conducted in a single center, open-label study with a single group fixed sequence design to evaluate the effect of repeated oral administration of 600 mg RIF(Rifampicin) given once daily over 11 days on the…
- Trial name
- NCT02975440
- Testing
- Rifampicin, Midazolam, BAY1002670_Vilaprisan
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bayer
HIV
Pharmacokinetics of Efavirenz in the Presence of Rifampicin and Isoniazid
The purpose of the study is to measure the drug levels in the blood of HIV-infected individuals taking anti- HIV medication efavirenz 400 mg once daily in the presence of anti-TB medication rifampicin and isoniazid.
- Trial name
- NCT02832778
- Testing
- Efavirenz, tenofovir /emtricitabine, tenofovir/lamivudine
- Where
- 2 sites in Uganda, United Kingdom
- Volunteers
- 35 people
- Sponsor
- St Stephens Aids Trust
Infection, Human Immunodeficiency Virus
Phase 1, Open Label, Two Arm, Fixed Sequence Study to Evaluate the Effect of Rifampin and Rifabutin on GSK1349572 Pharmacokinetics in Healthy Male and Female Volunteers
This study will be a phase I, open label, two arm, fixed sequence crossover study to investigate the effect of rifampin and rifabutin on the steady state pharmacokinetics (PK) of GSK1349572 and the safety and tolerability of…
- Trial name
- NCT01231542
- Testing
- GSK1349572, Rifampin, Rifabutin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Healthy Volunteers
A Study of Baricitinib and Rifampicin in Healthy Participants
The purposes of this study are to look at what effect multiple doses of rifampicin have on a single dose of baricitinib and to look at the safety and tolerability of these drugs. Side effects will be documented.
- Trial name
- NCT01910311
- Testing
- Baricitinib, Rifampicin
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Leprosy
Uniform Multidrug Therapy Regimen for Leprosy Patients
The purpose of this randomized trial is to verify if leprosy patients, despite of their classification, can be treated with the same regimen without compromising patient cure and acceptability of the treatment.
- Trial name
- U-MDT (NCT00669643)
- Testing
- PB 6 doses - Rifampicin and Dapsone, PB 6 doses - Rifampicin, Clofazimine and Dapsone, MB 12 doses - Rifampicin, Clofazimine and Dapsone
- Where
- 2 sites in Brazil
- Volunteers
- 859 people
- Sponsor
- University of Brasilia
Tuberculosis, Meningeal
High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study
Tuberculous meningitis (TBM) is the most severe form of tuberculosis infection with high mortality. Current treatment regimens are not based on clinical trials.
- Trial name
- ReDEFINe (NCT02169882)
- Testing
- Rifampicin, Other TB drugs, Adjuvant dexamethasone
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Mycobacterium Avium Complex
Use of Azithromycin and Rifabutin Administered 3 Times Weekly for the Treatment of M. Avium Complex (MAC) Lung Disease
To determine the safety and efficacy of azithromycin, rifabutin and ethambutol given three times weekly in the treatment of lung infection with M. avium complex(MAC)
- Trial name
- NCT00598962
- Testing
- Azithromycin, Rifabutin/rifampin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center at Tyler
Cystic Fibrosis, Methicillin-resistant Staphylococcus Aureus
Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)
Purpose: There has been a recent, rapid increase in prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) among patients with Cystic Fibrosis (22% across US CF centers in 2009).
- Trial name
- STAR-Too (NCT01349192)
- Testing
- Rifampin, Trimethoprim/Sulfamethoxazole, Minocycline
- Where
- 13 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis
The Bioavailability of Rifampicin in (FDCs) Widely Used in South Africa to Treat Drug-susceptible (TB)
3-way cross-over single dose design evaluating bioavailability of 2 rifampicin-containing FDCs vs a single drug comparator in healthy volunteers
- Trial name
- BIO3FDC (NCT02953847)
- Testing
- Rimactane, Rifafour e-275, Rimactazid 150/75
- Where
- South Africa
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Tuberculosis
TMC207 +/- Rifabutin/Rifampin
Evaluation of effect of rifampin or rifabutin on single dose PK of TMC207 in healthy volunteers
- Trial name
- NCT01341184
- Testing
- Rifabutin, Rifampin, TMC207
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Rifapentine Plus Moxifloxacin for Treatment of Pulmonary Tuberculosis
Although effective therapy for tuberculosis is available, TB continues to cause significant problems worldwide, and rates of multi-drug resistant (MDR) TB cases are on the rise.
- Trial name
- NCT00728507
- Testing
- Rifapentine, Moxifloxacin, Pyrazinamide, Isoniazid, Isoniazid, Rifampin, Pyrazinamide, Ethambutol
- Where
- 3 sites in Brazil
- Volunteers
- 121 people
- Sponsor
- Johns Hopkins University
Tuberculosis
Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Rifampicin in Healthy Volunteers
The purpose of this study is to evaluate the bactericidal activity against Mycobacterium tuberculosis of standard and high doses of rifampicin.
- Trial name
- NCT02387242
- Testing
- Rifampicin
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Tuberculosis
Evaluating Celecoxib Activity in Mycobacterium Tuberculosis: A Whole Blood Bactericidal Activity Study in Healthy Volunteers
The purpose of this study is to evaluate the bactericidal activity against Mycobacterium tuberculosis of celecoxib in combination with established drugs used to treat tuberculosis (TB).
- Trial name
- NCT02602509
- Testing
- Celecoxib, Rifampicin, Pyrazinamide
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Tuberculosis
Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Faropenem Plus Amoxicillin/Clavulanic Acid in Healthy Volunteers
The purpose of this study is to evaluate the bactericidal activity against Mycobacterium tuberculosis of faropenem boosted with amoxicillin/clavulanic acid.
- Trial name
- NCT02393586
- Testing
- Faropenem, Amoxicillin/clavulanic acid 500mg/125mg, Rifampicin
- Where
- Singapore
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Pulmonary Tuberculosis
Controlled Comparison of Two Moxifloxacin Containing Treatment Shortening Regimens in Pulmonary Tuberculosis
REMoxTB is a study for the "Rapid Evaluation of Moxifloxacin in the treatment of sputum smear positive tuberculosis". REMoxTB aims to find and evaluate new drugs and regimens that shorten the duration of tuberculosis therapy.
- Trial name
- REMoxTB (NCT00864383)
- Testing
- Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin
- Where
- 47 sites in China, India and 7 more
- Volunteers
- 1,931 people
- Sponsor
- Global Alliance for TB Drug Development
Tuberculosis, Pulmonary
Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis
The purpose of the study is to evaluate the safety and efficacy of two shortened regimens for newly diagnosed smear positive drug susceptible pulmonary tuberculosis in comparison to World Health Organization recommended standard…
- Trial name
- NCT02901288
- Testing
- Isoniazid, Rifampicin, Pyrazinamide
- Where
- 35 sites in China
- Volunteers
- 3,900 people
- Sponsor
- Beijing Chest Hospital
Tumor
To Assess the Effect of Rifampicin on the Pharmacokinetics of Eribulin Mesylate in Participants With Advanced Solid Tumors
The primary objective of this study was to assess the effect of cytochrome P450 3A4 enzyme (CYP3A4) induction by rifampicin on the pharmacokinetics (PK) of eribulin mesylate following intravenous (IV) administration in…
- Trial name
- NCT03002493
- Testing
- Eribulin mesylate, Rifampicin
- Where
- 2 sites in Netherlands
- Volunteers
- 14 people
- Sponsor
- Eisai Limited
Healthy Participants
Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects
The purpose of this study is to determine the effects of concomitant administration with fluconazole, itraconazole, and rifampin on the pharmacokinetics (PK) of a single 20-mg dose of avatrombopag in healthy participants.
- Trial name
- NCT02809768
- Testing
- Avatrombopag, Fluconazole, Itraconazole
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
HIV Infection
Immune Activation and Drug Absorption in HIV-Infected Patients
The investigators' objective is to describe the variability of rifampicin absorption, markers of inflammation and gut damage, intestinal absorptive capacity, and intestinal permeability among HIV-infected volunteers.
- Trial name
- NCT01845298
- Testing
- Rifampicin 600 mg
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Drexel University