Clinical trials: Sertraline
Major Depressive Disorder
Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder
An outpatient study to evaluate the safety and efficacy of cariprazine as adjunct to antidepressant therapy (ADT) in participants with major depressive disorder (MDD) who have an inadequate response to ADT alone.
- Trial name
- NCT01469377
- Testing
- Cariprazine
- Where
- 72 sites in United States, Estonia and 4 more
- Volunteers
- 819 people
- Sponsor
- Forest Laboratories
Depression
An 8-week, Open-label Study to Evaluate the Effect of Sertraline on Polysomnogram in Depressive Patients With Insomnia
Major depressive disorder is associated with several sleep Polysomnograph (PSG) findings: (1) impaired sleep continuity; (2) non-REM (NREM) changes; and (3) enhanced rapid eye movement (REM) sleep.
- Trial name
- NCT01032434
- Testing
- sertraline
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Guang Dong Provincial Mental Health Institute
Obsessive-Compulsive Disorder
The Study of Mindfulness Based Cognitive Therapy and Obsessive-Compulsive Disorder
The primary objective of the study is to evaluate the clinical curative effect of MBCT to reduce obsessive and compulsive symptoms.
- Trial name
- NCT03179839
- Testing
- Mindfulness-based Cognitive Therapy, Psycho-education Program, sertraline, fluvoxamine
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Shanghai Mental Health Center
Obsessive Compulsive Disorder (OCD)
Reducing Maximal Support in OCD: Efficacy of Stepped-Care Online CBT
This study is conducted to explore the efficacy and cost-effectiveness of stepped-care internet-based cognitive behavior therapy (sc-ICBT) with reduced support compared to cognitive-behavioral group therapy(CBGT), to identify the…
- Trial name
- NCT06659094
- Testing
- stepped-care Internet-based cognitive behavioral therapy(SC-ICBT), Cognitive Behavioral Group Therapy (CBGT), conventional medical treatment (TAU)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Shanghai Mental Health Center
Major Depression
Thyroid Medication and Antidepressants for Treating Major Depression
This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder…
- Trial name
- NCT00208702
- Testing
- Triiodothyronine, Sertraline
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Emory University
Panic Disorder
Special Investigation Of J Zoloft For Panic Disorder Patients
The objective of this surveillance is to collect information for panic disorder patients about 1) adverse drug reactions not expected from the LPD (unknown adverse drug reactions), 2) the incidence of adverse drug reactions in…
- Trial name
- NCT00605917
- Testing
- Sertraline hydrochloride
- Volunteers
- 997 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
PTSD, Posttraumatic Stress Disorder
Biomarkers in the Retina for Prognosticating Mental Health Treatments
Title: ERG as a potential biomarker of SSRI-responsive PTSD: A pilot study Posttraumatic stress disorder (PTSD) affects many individuals who experience a traumatic event.
- Trial name
- BRIGHT (NCT06363968)
- Testing
- RETeval
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Puget Sound Health Care System
Adverse Drug Events, Adverse Drug Reactions
YouScript IMPACT Registry
This multicenter observational study aims to investigate the benefits of providing pharmacogenetic testing with the YouScript Personalized Prescribing System which includes a clinical decision support tool and individualized…
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- IMPACT (NCT02191358)
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Genelex Corporation
Major Depressive Disorder
Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment
Background. Depression is a highly frequent condition in the elderly, with a huge impact on quality of life, life expectancy, and medical outcomes.
- Trial name
- VESPA (NCT03779789)
- Testing
- Vortioxetine, Sertraline, citalopram
- Where
- 3 sites in Italy
- Volunteers
- 362 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Major Depression, Bipolar Disorder
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
The purpose of this project is to determine whether concurrent treatment of patients with major depression (unipolar or bipolar) with triiodothyronine (T3) and sertraline, will lead to a stronger and/or more rapid antidepressant…
- Conditions
- Major Depression, Bipolar Disorder, Unipolar Depression
- Trial name
- NCT00158990
- Testing
- triiodothyronine, sertraline
- Where
- 2 sites in United States, Israel
- Volunteers
- 220 people
- Sponsor
- Hadassah Medical Organization
Depression - Major Depressive Disorder, Depressive Episodes
TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children
Depression in childhood and adolescence is a serious and increasing public-health problem associated with profound short- and long-term consequences, including impaired social and educational functioning, increased risk of…
- Trial name
- NCT07478796
- Testing
- Fluoxetine, Escitalopram, Sertralin
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Poznan University of Medical Sciences
Major Depressive Disorder
A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder
Major depressive disorder (MDD) is a serious medical illness associated with significant suicidal risk and marked disability. Despite the availability of numerous treatments, achievement of consistent and favorable long-term…
- Trial name
- NCT03538691
- Testing
- Brexpiprazole, Antidepressant therapy
- Where
- United States
- Volunteers
- 1,149 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Alcoholism
Sertraline Pharmacotherapy for Alcoholism Subtypes
The purpose of this study is to determine whether Sertraline, compared to placebo, is effective in the treatment of alcohol dependence as a function of the subtype of alcoholic patient being treated.
- Trial name
- NCT00368550
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- UConn Health
Major Depressive Disorder With Psychotic Features
Study of Pharmacotherapy of Psychotic Depression
This study will determine the effectiveness of combining selective serotonin reuptake inhibitors (SSRIs) with antipsychotic medications in the treatment of psychotic depression.
- Trial name
- STOP-PD (NCT00056472)
- Testing
- Olanzapine, Sertraline
- Where
- 4 sites in United States, Canada
- Volunteers
- 259 people
- Sponsor
- Weill Medical College of Cornell University
Psychogenic Non-Epileptic Seizure
TMS vs Conventional Therapy for the Treatment of Functional Neurological Non Epileptic Seizure Disorder
The aim of the study is to compare the effect of Transcranial Magnetic Stimulation (TMS) versus treatment with selective serotonin reuptake inhibitors (SSRIs), in patients with diagnosis of Functional Neurological Non Epileptic…
- Trial name
- NCT05241366
- Testing
- Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Major Depressive Disorder, Anxiety Disorders
Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients
The objective of this transversal study is to determine if there is a difference in the volume of the hippocampus with the degree of anxiety.
- Trial name
- NCT04430556
- Testing
- Sertraline
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Anxiety Disorders
Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder
This study will attempt to identify gene and brain activity markers that predict whether people with social anxiety disorder will respond to selective serotonin reuptake inhibitor medications.
- Trial name
- NCT00872131
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Generalized Anxiety Disorder
Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging Mechanisms
This study aims to evaluate the clinical efficacy and safety of electroacupuncture (EA) as an adjunctive treatment for generalized anxiety disorder (GAD).
- Trial name
- NCT07392645
- Testing
- Electroacupuncture (EA), Medication
- Where
- China
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Lishu Gao
Major Depressive Disorder
Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity Markers
This randomized controlled clinical trial evaluates the effectiveness of psilocybin and psilocybin-assisted cognitive behavioral therapy (CBT) in the management of Major Depressive Disorder (MDD).
- Trial name
- NCT06746441
- Testing
- Psilocybin, Cognitive Behavioral Therapy (CBT)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Medical University Peshawar
Obsessive-Compulsive Disorder
Pragmatic Trial of Obsessive-compulsive Disorder
This study includes a sequenced clinical trial in order to assess the efficacy of several switching or augment strategies when initial treatment is ineffective，and to provide strong evidence for clinical practice and…
- Trial name
- Proceed (NCT04539951)
- Testing
- Sertraline 200 milligram(mg), Sertraline 300 milligram(mg), Fluvoxamine
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Shanghai Mental Health Center