Clinical trials: Sertraline
Major Depressive Disorder
Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanics
This study will determine whether combination treatment driven by patient choice is better than standardized medication treatment at retaining and improving Hispanic patients with major depressive disorder.
- Trial name
- NCT00742573
- Testing
- Antidepressants through Texas Medication Algorithm (TMA), Brief Interpersonal Psychotherapy (IPT-B)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- New York State Psychiatric Institute
Depression - Major Depressive Disorder
Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode Depression Who Are Drug-naive: A Randomized, Double-blind, Controlled Pilot Study
To evaluate the efficacy of tACS treatment.To determine whether tACS can accelerate symptom remission, improve clinical response rates, and facilitate the recovery of emotional and cognitive functions through standardized…
- Trial name
- NCT07185464
- Testing
- tACS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Generalized Anxiety Disorder
Pharmacological Treatment of Generalized Anxiety Disorder in the Elderly
Generalized anxiety disorder (GAD) is a very common disorder in the geriatric population with prevalence rates reaching 7% and even higher rates of 8% among elderly veterans.
- Trial name
- Sert-GAD (NCT00701675)
- Testing
- sertraline 50 mg daily, sertraline 100 mg daily
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Depression
Treatments for Depression: Drug Versus Psychotherapy
This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.
- Trial name
- NCT00043550
- Testing
- Supportive Expressive Therapy, Sertraline, Venlafaxine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Breast Cancer, Depression
Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline
RATIONALE: Studying samples of blood in the laboratory from patients receiving tamoxifen may help doctors learn more about the effects of other drugs on the level of tamoxifen in the blood.
- Conditions
- Breast Cancer, Depression, Hot Flashes, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00667121
- Testing
- citalopram hydrobromide, escitalopram oxalate, gabapentin
- Where
- 6 sites in United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic
Depressive Disorder, Major
Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The purpose of this study is to determine whether transcranial direct current stimulation is an effective treatment for major depression, when compared (and combined) to sertraline and placebo.
- Trial name
- SELECT-TDCS (NCT01033084)
- Testing
- transcranial direct current stimulation, Sertraline
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Treatment Resistant Depression
Interpersonal Psychotherapy for Treatment Resistant Depression
The purpose of this study is to determine whether combination of antidepressant drugs plus interpersonal psychotherapy is superior to antidepressant drugs alone in treatment resistant depression.
- Trial name
- NCT01896349
- Testing
- IPT+ antidepressant drugs, fluoxetine, sertraline
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cocaine-Related Disorders
Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified placebo-controlled experimental design.
- Trial name
- NCT00015132
- Testing
- Sertraline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Major Depressive Disorder (MDD), Probiotic Intervention
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
The goal of this clinical trial is to evaluate the efficacy and safety of sertraline combined with Lactobacillus crispatus in adolescents aged 12-18 years with major depressive disorder.
- Trial name
- NCT07539805
- Testing
- Sertraline combined with Lactobacillus crispatus
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Depression
Brain Activity Changes and Treatment Response in Depressed People Who Are Receiving Antidepressant Medication
This study will examine how brain activity is affected by antidepressant treatment and how changes in brain activity relate to treatment response in people with depression.
- Trial name
- NCT00375843
- Testing
- Escitalopram, Sertraline
- Where
- 3 sites in United States
- Volunteers
- 118 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder
Treatment of Obsessive Compulsive Disorder in Children
This study will determine whether cognitive behavioral therapy delivered by either psychologists or psychiatrists can improve the effectiveness of serotonin reuptake inhibitor treatment in children with obsessive compulsive…
- Trial name
- NCT00074815
- Testing
- Serotonin reuptake inhibitors management, Cognitive behavioral therapy by a psychologist, Instructional cognitive behavioral therapy by a psychiatrist
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- Duke University
Depressive Disorder
Randomized Double Blinding Controlled Study on" Jia Wei Xiao Yao Jiaonang" Treating Mild to Moderate Major Depressive Disorder
This is a randomized, double-blind multi centric clinic study. Both of therapist and patient are blind. There are 180 patients from 3 hospitals included, who meet DSM-IV criteria for major depressive disorder, the score of…
- Trial name
- NCT01467804
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Su Rui
Psychologic Manipulation
Cognitive Processing Therapy vs. Sertraline for the Treatment of PTSD & SUD in Egyptian Patients
The present research was aimed at comparing the effects of Cognitive Processing Therapy (CPT) with the effects of Sertraline in treating patients who have dual diagnosis PTSD \& SUD.
- Trial name
- NCT03469128
- Testing
- Cognitive processing therapy, Sertraline
- Volunteers
- 150 people
- Sponsor
- British University In Egypt
Taste Disorders
Gustatory Dysfunction Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy
Assess gustatory thresholds among a sample of depressed Egyptian adults (age from 20 to 50 years old) under anti-depressants therapy ( for at least 3 months) using filter paper disc(FPD) method through a scoring system.
- Trial name
- NCT03599011
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Major Depression
Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene
The study evaluates the ABCB1-genotype dependent efficacy of a quick dose-escalation strategy within 28 days of treatment with approved antidepressants that are known substrates of the P-glycoprotein, an efflux pump of the…
- Trial name
- NCT02237937
- Testing
- Paroxetine, Sertraline, Citalopram
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HolsboerMaschmeyer NeuroChemie GmbH
Depression
Omega-3 for Depression and Other Cardiac Risk Factors - 2
The purpose of this 10 week randomized, placebo-controlled, double-blind clinical trial is to determine whether antidepressant augmentation with two grams of EPA omega-3 per day is superior to antidepressant therapy alone for…
- Trial name
- Omega-3(2) (NCT02021669)
- Testing
- Omega-3 supplement
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Deprescription, Antidepressants
Deprescription of Antidepressants in Primary Care (DAPriCare)
Introduction The consumption of antidepressants has increased considerably worldwide, including in Spain. Despite their effectiveness in cases of moderate to severe depression, their long-term use in mild cases is questioned.
- Trial name
- DAPriCare (NCT06796946)
- Testing
- Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram)
- Where
- Spain
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Huelva
Fragile X Syndrome
Trial of Sertraline to Treat Children With Fragile X Syndrome
This study is a control trial of sertraline (Zoloft) in fragile X syndrome children aged 2 years to 5 years 8 months old. The trial is six months long, and each participant will receive a series of tests at both the beginning and…
- Trial name
- NCT01474746
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Randi J. Hagerman, MD
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Emotional Distress, Emotional Disorder
The Mechanism of Mindfulness Intervention to Alleviate Emotional Distress in Patients With Emotional Disorders
This study hopes to: 1. explore whether offline and online mindfulness interventions can significantly alleviate individual emotional distress,experiential avoidance and improve cognitive flexibility,distress tolerance level. 2.
- Trial name
- NCT05891015
- Testing
- Mindfulness Intervention for Emotional Distress(MIED)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University