Clinical trials: Sildenafil
IVF
Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes
The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization.
- Trial name
- NCT05971667
- Testing
- tadalafil, Sildenafil, pentoxifylline
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Pulmonary Hypertension
Effectiveness of the Vasodilator Test With Revatio, Made in Patients With Acute Pulmonary Hypertension
The main objective is to validate the safety and efficacy of intravenous and oral sildenafil in the acute vasodilator test in patients with persistence of, at least, moderate pulmonary hypertension after valvular surgery…
- Trial name
- NCT01091012
- Testing
- Sildenafil 20mg oral vs Sildenafil 10mg intravenous
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Renal Transplant Failure
PDE5i Use in Renal Transplant Recipients
Ischemia-reperfusion (IRI) injuries are common in renal transplantation and cause poor patient outcomes. Ischemia occurs after the donor's death and reperfusion occurs after kidney implantation.
- Trial name
- NCT04122105
- Testing
- Sildenafil
- Where
- Canada
- Sponsor
- University of British Columbia
Female Infertility
Clomiphene Citrate, Estradiol and Sildenafil for Induction of Ovulation in Unexplained Infertility
Diagnosis of unexplained infertility is made after the recommended testing fails to reveal any abnormality. The treatment for unexplained infertility is empiric because it does not address a specific defect or functional…
- Trial name
- NCT03755037
- Testing
- Clomid, Respatio and Ethinyl estradiol
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Nesreen Abdel Fattah Abdullah Shehata
Emphysema
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize…
- Trial name
- NCT02682147
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Eric A. Hoffman
Quality of Life
A Randomized Controlled Trial Evaluating Sildenafil Citrate in Relieving Ureteral Stent Related Symptoms
Despite its beneficial effect, ureteral stents may produce symptoms (such as hematuria, dysuria, frequency, urgency, urge incontinence and suprapubic or flank pain) that affect the quality of life in 70-80%.
- Trial name
- NCT02345980
- Testing
- Sildenafil
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- Mansoura University
Angina Pectoris
Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina
The purpose of the study is to determine for how long sildenafil potentiates the blood pressure reduction that occurs with glyceryl trinitrate in men with angina.
- Trial name
- NCT00479908
- Testing
- Sildenafil citrate, Glyceryl trinitrate
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Rectal Tumors, Erectile Dysfunction
Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer
Although the high prevalence of erectile dysfunction (ED) was detected among male patients after the treatment for colorectal cancer, published reports depicting the erectile dysfunction experience of patients with colorectal…
- Trial name
- NCT01912586
- Testing
- vacuum erection device
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Erectile Dysfunction (ED), Erectile Dysfunctions
A Single-Arm, Dose Escalation of an Intraurethral Alprostadil Paste for Erectile Dysfunction
This is a single arm dose escalation trial of a mucoadhesive intraurethral polymer suspension of alprostadil (ST-04) and will investigate the efficacy of 3 dose levels of ST-04 in adult males with a clinical diagnosis of Erectile…
- Conditions
- Erectile Dysfunction (ED), Erectile Dysfunctions, Erectile Function
- Trial name
- NCT07601646
- Testing
- ST-04
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Ryan Flannigan, MD
Pulmonary Arterial Hypertension
Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants
The purpose of this study was to investigate the effects of QTI571 (imatinib) on pharmacokinetics of bosentan and sildenafil at steady state when co-administered to participants with pulmonary arterial hypertension.
- Trial name
- NCT01392469
- Testing
- Imatinib, Sildenafil, Bosentan
- Where
- 11 sites in United States, Australia and 5 more
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Impotence
Use of Sildenafil (Viagra) in Diabetic Men With Erectile Dysfunction: the Impact on Blood Vessels
To evaluate the impact of nightly sildenafil vs placebo use on diabetic men with and without proven endothelial dysfunction and coexisting erectile concerns.
- Trial name
- NCT00199563
- Testing
- Viagra
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pulmonary Arterial Hypertension (PAH)
Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterized by increased pressure in the pulmonary arteries, leading to right heart failure and premature death.
- Trial name
- ASCEND-PAH (NCT07713914)
- Testing
- Prostacyclin Pathway Agent, Sildenafil Dose Optimization
- Where
- Brazil
- Volunteers
- 196 people
- Sponsor
- University of Sao Paulo General Hospital
Endometrial Thickness
Effect Sildenafil and Estradiiol Valerate on Endometrial Thickness in Infertile Women
The endometrium is a dynamic tissue that responds to changing hormonal signals throughout the cycle. The changes in the endometrial composition are expressed in alteration in gene expression, micro architectural morphological…
- Trial name
- NCT03301233
- Testing
- estradiol valerate and sildenafil
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Erectile Dysfunction
A Study to Compare the Blood Levels of Sildenafil Following Administration of an Experimental Tablet vs. the Conventional Oral Tablet in Healthy Subjects
This study to will compare the blood levels of sildenafil following administration of an experimental tablet vs. the conventional oral tablet.
- Trial name
- NCT00866463
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Migraine Without Aura
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COMPETE (NCT05889455)
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Obesity
Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity
Obesity and metabolic disease result when energy intake consistently exceeds energy expenditure. One appealing new target for treatment is the activation of brown adipose tissue (BAT), an organ recently found to be functional in…
- Trial name
- NCT02524184
- Testing
- sildenafil
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Sickle Cell Anemia
Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to…
- Trial name
- NCT00937144
- Testing
- Viagra (Sildenafil)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Erectile Dysfunction
A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China
The primary objective of this study is to evaluate whether, after two 8-week treatment periods, male patients with erectile dysfunction (ED) in China prefer 20 milligram (mg) tadalafil or 100 mg sildenafil.
- Trial name
- NCT01352507
- Testing
- Tadalafil, Sildenafil
- Where
- 9 sites in China
- Volunteers
- 383 people
- Sponsor
- Eli Lilly and Company
Prostate Cancer
Effect of Nightly Versus Prn Sildenafil on Early Return of Erectile Function Following Laparoscopic Radical Prostatectomy
The ability of sildenafil to aid in the return of erections after nerve-sparing radical prostatectomy has been established. Patients who had either one or both neurovascular bundles spared demonstrated dramatically better…
- Trial name
- NCT00511498
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Sexual Arousal Disorder
Using Thermography to Assess the Affects of Sildenafil Cream, 3.6%
The goal of this clinical trial is to compare thermography images in normal healthy premenopausal women after the application of Sildenafil Cream, 3.6%, L-arginine cream, and placebo cream.
- Trial name
- NCT05765487
- Testing
- Sildenafil, Vehicle
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Daré Bioscience, Inc.