Clinical trials: Sildenafil
Vascular Diseases
Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support
Contemporary left ventricular assist device (LVAD) therapy improves survival during advanced heart failure but vascular aging develops rapidly leading to major adverse events including stroke and bleeding in nearly half of…
- Trial name
- NCT06510322
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Hepatic Encephalopathy.
Efficacy of Sildenafil in the Improvement of Cognition and Quality of Life in Patients With Cirrhosis of Liver. A Proof of Concept Study.
The study is being conducted to evaluate the efficacy of Sildenafil (a 5-phosphodiesterase inhibitor) as a means to improve the cognitive impairment encountered in patients of minimal hepatic encephalopathy (MHE) as proposed in…
- Trial name
- NCT02028429
- Testing
- Sildenafil.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pulmonary Arterial Hypertension
Combination Therapy in Pulmonary Arterial Hypertension
An open label, non-comparative study design is appropriate for this Phase 4 study designed to assess whether a core therapy of bosentan, either as monotherapy or with the addition of sildenafil, enables patients with pulmonary…
- Trial name
- COMPASS 3 (NCT00433329)
- Testing
- Bosentan, Sildenafil
- Volunteers
- 100 people
- Sponsor
- Actelion
Heart Failure, Diastolic, Pulmonary Hypertension
Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH
Aim of the study is to investigate whether Sildenafil treatment results in a reduction of pulmonary artery pressure without decrease of cardiac output (CO) and in improvement of exercise capacity in patients with heart failure…
- Trial name
- NCT01726049
- Testing
- Sildenafil
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- University Medical Center Groningen
Pulmonary Arterial Hypertension (PAH)
a Non-interventional Study of Sildenafil in the Treatment of Pulmonary Arterial Hypertension (PAH) in Adults From China
This observational study will involve analysis of data collected by the National Rare Disease Registry or medical records .The study will describe outcomes only in PAH(Pulmonary arterial hypertension) patients treated with…
- Trial name
- NCT05546125
- Testing
- as per Physician's prescription
- Where
- 7 sites in China
- Volunteers
- 100 people
- Sponsor
- Pfizer Pharmaceuticals Ltd.
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Intra-Uterine Growth Retardation
Sildenafil in Sever Intrauterine Growth Retardation
Severe fetal growth restriction (FGR) complicates approximately 0.4% of pregnancies and severely increases the risk of perinatal morbidity and mortality.Sildenafil citrate may offer a potential therapeutic strategy to improve…
- Trial name
- IUGR (NCT03153215)
- Testing
- treatment
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Beni-Suef University
Pulmonary Hypertension
To Provide Sildenafil Therapy To Eligible Adult Patients With Pulmonary Arterial Hypertension For 112 Weeks
The purpose of this study is to provide sildenafil therapy to eligible adult patients with pulmonary arterial hypertension (PAH) and to the patients who completed the A1481142 study for the treatment of PAH in Poland.
- Trial name
- NCT00946114
- Testing
- sildenafil
- Where
- 2 sites in Poland
- Volunteers
- 32 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Eisenmenger Syndrome
Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers Syndrome
The purpose of this study is to investigate if combination treatment with Bosentan and Sildenafil to patients with Eisenmenger syndrome is beneficial.
- Trial name
- NCT00303004
- Testing
- Bosentan and Sildenafil
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertension
A Study to Evaluate the Effect of Two Fixed-Dose Leucine, Sildenafil and Metformin Combinations on Blood Pressure in Individuals With Hypertension
This 12-week, randomized, double-blind, placebo-controlled Phase 2 study will evaluate two fixed-dose oral combinations of L-leucine, sildenafil, and metformin (NS-0200) versus matching placebo in adults 18-75 years with…
- Trial name
- NS-HTN-01 (NCT07647003)
- Testing
- NS-0200 (low sildenafil), NS-0200 (higher sildenafil)
- Volunteers
- 150 people
- Sponsor
- NuSirt Biopharma
Rectal Cancer
Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer
This study aims to evaluate the efficacy of erectile rehabilitation with Sildenafil, in men treated with neoadjuvant proctectomy and radiotherapy for rectal cancer, in preventing long-term erectile dysfunction at 12 months…
- Trial name
- RECTIL (NCT06123156)
- Testing
- Sildenafil
- Where
- 14 sites in France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Rouen
Pulmonary Arterial Hypertension
Local Open-Label Access Study For Patients Who Completed A1481244 Study In Brazil
The purpose of this study is to provide sildenafil therapy to patients who completed the A1481244 study for the treatment of PAH, and reside in Brazilian States where Revatio™ is not supplied by Health Secretary, and are judged…
- Trial name
- NCT00866983
- Testing
- sildenafil (Revatio) 20 mg TID
- Where
- 2 sites in Brazil
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Erectile Dysfunction
Effect of Moderate Alcohol on Absorption and Onset of Hezkue Sildenafil Suspension
This is a Phase 2, open-label, randomized crossover study assessing the effect of moderate alcohol intake on the absorption and onset of action of Hezkue® sildenafil oral suspension in adult subjects.
- Trial name
- NCT07290400
- Testing
- Hezkue Sildenafil Oral Suspension, Moderate Alcohol Intake
- Volunteers
- 36 people
- Sponsor
- Aspargo Labs, Inc
Thalassemia
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension
This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia
- Trial name
- NCT03402191
- Testing
- L-arginine, Sildenafil
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sherief Abd-Elsalam
Metabolic Syndrome
Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle.
Our research proposal will determine if PDE-5 inhibition exerts a favorable effect on insulin signaling pathways in skeletal muscle of subjects with impaired fasting glucose and/or impaired glucose tolerance.
- Trial name
- NCT02129725
- Testing
- Sildenafil citrate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Neonates and Preterm Infants
PK Study of Sildenafil in Neonate
The purpose of this study is to investigate the pharmacokinetics of sildenafil which is used as treatment of pulmonary hypertension in neonate and preterm infant.
- Trial name
- NCT02244528
- Testing
- Sildenafil
- Where
- 2 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Fatigue, Aging
Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older…
- Trial name
- NCT01059994
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Erectile Dysfunction
Quality of Erection Study
The study objective is to evaluate the effect that sildenafil citrate has on the hardness of erections in males with erectile dysfunction, based on subject responses to question 5 on the Event Log (hardness of erection) as…
- Trial name
- NCT00159900
- Testing
- Sildenafil Citrate
- Where
- 23 sites in Brazil, Germany and 3 more
- Volunteers
- 300 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Fetal Growth Retardation
Vitamin D Versus Sildenafil Citrate in Fetal Growth Restriction
Fetal growth restriction, also named Intrauterine growth restriction is a prevalent disease in pregnancy , it is a descriptive term for a pathological process, and can be described as the process where a fetus who has a certain…
- Trial name
- NCT06565728
- Testing
- Vitamin D3 2000 UNT Oral Tablet
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Cairo University
Migraine With Aura
Pharmacologically Triggered Migraine Without Aura and Neuroimaging
Migraine is a highly disabling disorder affecting 14% of the general population Worldwide and ranked as the 6th most debilitating disease worldwide by the WHO.
- Trial name
- NCT03143465
- Testing
- Calcitonin Gene-Related Peptide, Sildenafil
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center