Clinical trials: Sildenafil
Prostate Cancer
Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer
RATIONALE: Nerve-sparing radical prostatectomy with nerve grafting followed by standard therapies for erectile dysfunction may be effective in helping patients with prostate cancer improve sexual satisfaction and quality of life.
- Trial name
- NCT00080808
- Testing
- Alprostadil (E1), Papaverine, Phentolamine mesylate
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- M.D. Anderson Cancer Center
Infertility
Thermosensitive Gels for the Vaginal Delivery of Sildenafil Citrate
The aim of this study was to develop and characterize in situ thermosensitive gels for the vaginal administration of sildenafil as a potential treatment of the endometrial thinning that occurs as a result of the use of clomiphene…
- Trial name
- ss (NCT02766725)
- Testing
- preparation F12 sildenafil in situ gel, preparation F2 sildenafil in situ gel
- Volunteers
- 90 people
- Sponsor
- Assiut University
Acute Kidney Injury
A Study to Determine the Pharmacokinetic Profile, Safety and Tolerability of Sildenafil (REVATIO®) in Cardiac Surgery
The objectives of the study are the following: To evaluate the pharmacokinetic profile of Sildenafil in cardiac surgery patients at risk of acute kidney injury To determine the safety and tolerability of Sildenafil in cardiac…
- Trial name
- Revaki-001 (NCT02136329)
- Testing
- Sildenafil
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Leicester
Safety
FDA Phase IV - Commitment - Retinal Function Study
Vardenafil (Levitra) and Sildenafil (Viagra) are drugs that are marketed for use in patients with erectile dysfunction. The purpose of this study is to find out if there are any changes in the eye after taking at least 15 doses…
- Trial name
- NCT00461565
- Testing
- Sildenafil, Vardenafil (Levitra, BAY38-9456)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Bayer
Pharmacokinetics of Three PDE5Is, Healthy Subjects
The Effect of CYP3A Genetic Polymorphism on the Pharmacokinetics of Phosphodiesterase type5 Inhibitors in Male Subjects
In order to evaluate the effect of CYP3A5*3 allele on the pharmacokinetics of sildenafil, udenafil, and vardenafil, the clinical trial using a single oral dose was conducted in Korean healthy male subjects whose genotype of…
- Conditions
- Pharmacokinetics of Three PDE5Is, Healthy Subjects, Genetic Polymorphic CYP3A5
- Trial name
- CYP3APDE5I (NCT00767598)
- Testing
- phosphodiesterase type 5 inhibitor
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Inje University
Pulmonary Arterial Hypertension
Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAH
The development of disease-targeted medication for the treatment of pulmonary arterial hypertension (PAH) has significantly improved within the last years, leading to the development of 10 approved agents.
- Trial name
- EPIC (NCT02484807)
- Testing
- no intervention, only observation of different groups
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Heidelberg University
Neonatal Asphyxia, Intrapartum Fetal Distress
Intrapartum Sildenafil in Laboring Mothers
The goal of this feasibility pilot clinical trial is to learn if sildenafil citrate 50mg orally, up to three times during labor, can be appropriately administered, with limited clinical side effects, to laboring mothers to…
- Conditions
- Neonatal Asphyxia, Intrapartum Fetal Distress, Development, Infant, Intrapartum Asphyxia
- Trial name
- PRISM (NCT06377098)
- Testing
- Sildenafil 50 mg Oral Tablet
- Where
- 3 sites in Cameroon, Kenya and 1 more
- Sponsor
- University of Alabama at Birmingham
Persistent Pulmonary Hypertension of the Newborn
Pharmacokinetics of Sildenafil in Premature Infants
The purpose of this study is to learn more about the safety and dosing of sildenafil in infants.
- Trial name
- NCT01670136
- Testing
- 1 dose of sildenafil
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetic Neuropathy
An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus)
The purpose of this study is to study if sildenafil (Viagra) is effective in improving neuropathic pain. This will be an open label study at 3 doses of sildenafil (25 mg, 50 mg and 100 mg).
- Trial name
- NCT00194909
- Testing
- sildenafil (Viagra)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Weill Medical College of Cornell University
Impotence
Effectiveness and Safety of Viagra in Men With ED and LUTS Due to Benign Prostatic Hyperplasia (BPH)
The purpose of this study is to determine whether Viagra is effective in treating erectile dysfunction and lower urinary tract symptoms in men affected by both conditions.
- Trial name
- NCT00143221
- Testing
- Viagra
- Volunteers
- 350 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pulmonary Arterial Hypertension
An Open Label Access Study For Subjects Who Completed A1481156
The purpose of this study is to provide sildenafil therapy to subjects who have completed the A1481156 study for the treatment of Pulmonary Arterial Hypertension (PAH) in India and are judged by the Investigator to derive…
- Trial name
- NCT01582438
- Testing
- Access program - sildenafil citrate, Viagra, Revatio
- Where
- India
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Erectile Dysfunction
French Study in Real Life Evaluating Xybilun
Collecting Xybilun (Viagra's generic) efficacity, tolerance, convenience and patients/doctors satisfaction's data at different doses (50-75-100 mg), is the aim of the study.
- Trial name
- XY-FILM (NCT04114240)
- Testing
- Xybilun
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Laboratoires Genévrier
Hernia, Diaphragmatic, Hypertension, Pulmonary
Chronic Sildenafil for Severe Diaphragmatic Hernia
The purpose of this study is to test if sildenafil is effective in the treatment of infants with severe congenital diaphragmatic hernia (determined by the presence of prolonged pulmonary hypertension or prolonged oxygen…
- Conditions
- Hernia, Diaphragmatic, Hypertension, Pulmonary, Hypoplasia, Pulmonary
- Trial name
- NCT00133679
- Testing
- sildenafil
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Pulmonary Hypertension Associated With Connective Tissue Disease
VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension
Sildenafil is a selective pulmonary vasodilator; in patients with a special kind of pulmonary hypertension it is approved for treatment.
- Trial name
- SIL-REACT (NCT01889966)
- Testing
- Sildenafil
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Kerckhoff Heart Center
Birth Asphyxia
Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia
The investigators will determine the maximum tolerable dose of sildenafil and establish the pharmacokinetic and pharmacodynamic profile of sildenafil in human asphyxiated neonates treated with hypothermia.
- Trial name
- SANE-02 (NCT04169191)
- Testing
- Sildenafil Citrate
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients
Pulmonary diseases are increasingly important causes of morbidity and mortality in the modern world. Sildenafil, an orally administered a phosphodiesterase type 5 (PDE-5) inhibitor, targets the nitric oxide (NO) pathway.
- Trial name
- NCT01382368
- Testing
- Sildenafil
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Hypertension, Pulmonary, Diseases of Mitral Valve
Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial)
The purpose of this study is to determine whether Sildenafil is effective in the treatment of sustained pulmonary artery hypertension after corrected mitral valve disease.
- Trial name
- SUPERIOR (NCT02435303)
- Testing
- Sildenafil
- Volunteers
- 2 people
- Sponsor
- Asan Medical Center
Pre-Eclampsia; Mild
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia
Mild pre-eclampsia represents 75% of cases with pre-eclampsia, possible progression to severe pre-eclampsia makes mild pre-eclampsia a serious problem that requires attention.
- Trial name
- NCT03262961
- Testing
- Sildenafil 20 MG
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Erectile Dysfunction
Efficacy and Safety Study of Combined Oral and Injection Therapy for Erectile Dysfunction
Erectile dysfunction (ED or impotence) is a common medical condition affecting many men world wide. The most commonly used treatment for ED are oral medications like Viagra (sildenafil), Levitra (vardenafil) and Cialis…
- Trial name
- NCT00507286
- Testing
- combination of various doses of sildenefil and alprostadil
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Keogh Institute for Medical Research
Pulmonary Arterial Hypertension
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)
COMPASS-2 is a Phase 4, prospective, randomized, double-blind, placebo-controlled, event-driven study evaluating the effect of bosentan on the time to first confirmed morbidity/mortality event in patients with symptomatic PAH…
- Trial name
- Compass-2 (NCT00303459)
- Testing
- bosentan
- Volunteers
- 334 people
- Sponsor
- Actelion