Clinical trials: Sildenafil
Bladder Cancer
Role of Low-intensity Shock Wave Therapy in Penile Rehabilitation Post Nerve Sparing Radical Cysto-prostatectomy
The aim of this clinical trial is to evaluate the role of extracorporeal low-intensity shock wave therapy in penile rehabilitation post nerve sparing radical cysto-prostatectomy.
- Trial name
- NCT02422277
- Testing
- LI-ESWT group, PDE-5 inhibitors group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Diabetes Mellitus, Type 2, Endothelial Dysfunction
Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes
Type 2 Diabetes Mellitus (T2DM) represents a model of endothelial dysfunction, where chronic nitric oxide deprivation, hyperglycaemia and hyperinsulinemia and fibrogenic mediators lead to cardiovascular remodelling associated…
- Trial name
- CECSID (NCT00692237)
- Testing
- Sildenafil
- Where
- Italy
- Volunteers
- 59 people
- Sponsor
- University of Roma La Sapienza
Infertility
Effect of Vaginal Sildenafil Citrate on Endometrial Preparation and Outcome in Frozen Thawed Embryo Transfer Cycles
A total of 80 Patients who meet these conditions will enter the study and be divided into two groups based on randomized tables.
- Trial name
- NCT03854175
- Testing
- sildenafil citrate, Estradiol Valerate 2 MG
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Persistent Pulmonary Hypertension of the Newborn
Pharmacokinetics of Sildenafil in Premature Infants
The purpose of this study is to learn more about the safety and dosing of sildenafil in infants.
- Trial name
- NCT01670136
- Testing
- 1 dose of sildenafil
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension, Pulmonary
Study Evaluating the Addition of Sildenafil to Bosentan Therapy in Pulmonary Arterial Hypertension
This study will examine the effects of add-on sildenafil to bosentan monotherapy in patients with Pulmonary Arterial Hypertension.
- Trial name
- NCT00780728
- Testing
- Sildenafil
- Sponsor
- University Health Network, Toronto
Impaired Glucose Tolerance
Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis
The purpose of this study is to determine the effect of chronic PDE5 inhibitor therapy on glucose metabolism in persons with prediabetes.
- Trial name
- NCT01409993
- Testing
- Sildenafil, Hyperglycemic clamp, Euglycemic clamp
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University
Pulmonary Arterial Hypertension (PAH), Pulmonary Hypertension (PH)
COMPERA / COMPERA-KIDS
In view of the manifold options for mono- and combination therapy that have now emerged for patients with pulmonary (arterial) hypertension (PH/PAH), controlled clinical trials can only provide part of the information needed for…
- Trial name
- COMPERA (NCT01347216)
- Where
- 7 sites in Belgium, Germany and 2 more
- Volunteers
- 14,000 people
- Sponsor
- Technische Universität Dresden
IVF
Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes
The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization.
- Trial name
- NCT05971667
- Testing
- tadalafil, Sildenafil, pentoxifylline
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Peripheral Arterial Occlusive Disease
Efficacy of Sildenafil on the Morbi-mortality of Peripheral Arterial Diseased Patients With Intermittent Claudication
Peripheral Arterial Disease (PAD) is a highly debilitating disease that affects 202 million people around the world and about 7 million people in France. Morbi-mortality from cardiovascular events is increased in this population.
- Trial name
- VALSTAR (NCT02930811)
- Testing
- Sildenafil 100 mg oral morning dose
- Sponsor
- University Hospital, Angers
Erectile Dysfunction
A New Sildenafil Oral Film in Patients With Erectile Dysfunction
This is a Phase III, prospective, interventional, multi-center, randomized, double-blind, flexible-dose, placebo-controlled, parallel group clinical study required by FDA to demonstrate the efficacy and safety of Sildenafil oral…
- Trial name
- NCT05490680
- Testing
- Sildenafil Oral Film 25 mg, 50 mg, 75 mg or 100 mg
- Where
- 18 sites in United States
- Volunteers
- 488 people
- Sponsor
- IBSA Institut Biochimique SA
Congenital Disorders
Eisenmenger's Syndrome in Adults With CHD
Review the outcome of treatment with endothelin receptor antagonists (bosentan or sitaxsetan) alone or in combination with Sildenafil (a PDE-5 inhibitor) in adult patients with pulmonary hypertension due to congenital heart…
- Trial name
- NCT00266903
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Children's Healthcare of Atlanta
Congenital Disorders
Pulmonary Hypertension in Trisomy 21 Patients
Evidence has shown poor outcome for adult patients with pre-operative pulmonary hypertension following closure of an atrial septal defect.
- Trial name
- NCT00478296
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Healthcare of Atlanta
Healthy
Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males
The purpose of this study is to evaluate the safety and pharmacokinetics/pharmacodynamics of co-administration of Clomipramine HCl 15mg and Sildenafil citrate 100mg compared to the effects after single oral administration in…
- Trial name
- NCT02028598
- Testing
- Treatment 1, Treatment 2, Treatment 3
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CTC Bio, Inc.
Pediatric Pulmonary Hypertension
Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension
The investigators' central hypothesis is that early combination therapy with two PAH-specific oral therapies that have been shown to be well tolerated in the pediatric population, sildenafil and bosentan, will result in better…
- Trial name
- MoD (NCT04039464)
- Testing
- Mono-Therapy with Sildenafil, Duo-Therapy with Sildenafil + Bosentan
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Johns Hopkins University
Subarachnoid Hemorrhage, Cerebral Vasospasm
Sildenafil for DCI
Each year, approximately 30,000 people in the United States suffer an intra-cranial hemorrhage due to aneurysmal rupture. Of those surviving the initial event, up to 40% will go on to have further neurological injury secondary to…
- Trial name
- NCT03028298
- Testing
- Low dose sildenafil citrate, High dose sildenafil citrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Mississippi Medical Center
Hypoplastic Left Heart Syndrome, Tricuspid Atresia
Sildenafil After the Fontan Operation
In this study, the investigators will evaluate the effect of sildenafil on exercise tolerance in patients with a single cardiac ventricle who have undergone the Fontan operation.
- Trial name
- SAFO (NCT00507819)
- Testing
- Sildenafil
- Volunteers
- 28 people
- Sponsor
- Children's Hospital of Philadelphia
Erectile Dysfunction
A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil
The objective of this study was to determine and compare the minimum time required to achieve penile rigidity greater than or equal to 60% at the base of the penis that is sustained for at least 3 minutes measured by Rigiscan®…
- Trial name
- NCT00644956
- Testing
- tadalafil, sildenafil
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 56 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Alopecia Areata
A Novel Formulation of Sildenafil-loaded Nanocarriers for Treatment of Alopecia Areata
Alopecia areata (AA) is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Many theories were implicated in pathogenesis of AA, such as an autoimmune lymphocytic attack of the hair…
- Trial name
- NCT06527729
- Testing
- sildenafil-loaded liposomes, minoxidil gel
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Assiut University
Benign Prostatic Hyperplasia
A Study to Investigate the Effects on Blood Pressure and Pulse Rate of a Single 100mg Dose of Sildenafil in Patients With Benign Prostatic Hyperplasia Who Are Being Treated With Doxazosin
To investigate the effects of a single dose of sildenafil (100 mg) or placebo on blood pressure and pulse rate in subjects taking doxazosin for benign prostatic hyperplasia (BPH).
- Trial name
- NCT00645034
- Testing
- sildenafil
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
PPHN
Vardenafil Vs Sildenafil for the Treatment of Pulmonary Hypertension of the Newborn
The goal of this clinical trial is to learn if drug Vardenafil works to treat pulmonary hypertension in newborns, It will also learn about the safety of Vardenafil.
- Trial name
- PPHN (NCT06860399)
- Testing
- Vardenafil, Sildenafil
- Where
- Syria
- Volunteers
- 55 people
- Sponsor
- Damascus University