Clinical trials: Sildenafil
Multiple Sclerosis
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
This study will determine whether sildenafil citrate, commonly known as Viagra, can cause increased blood flow to the brain in a wide range of multiple sclerosis (MS) patients, including women.
- Trial name
- NCT00094068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Fetal Distress
Sildenafil Citrate and Intrapartum Fetal Distress
Induction of labour (IOL) is done for 20% of pregnancies for various maternal and fetal indications and nearly 20% of labour inductions end up in caesarean section.
- Trial name
- NCT04325243
- Testing
- Sildenafil 50 mg
- Where
- Egypt
- Volunteers
- 410 people
- Sponsor
- Assiut University
Congenital Heart Disease, Pulmonary Arterial Hypertension
Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension
The purpose of this study is to test the hypothesis that treating PAH-CHD patients preoperatively with PAH drugs and keeping them on treatment for six months after surgery reduces the risk of immediate postoperative death and the…
- Trial name
- NCT01548950
- Testing
- Sildenafil singly or in association with Bosentan
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Anemia, Cooley's, Beta-Thalassemia
Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)
The purpose of the TCRN is to accelerate research in the management of thalassemia, standardize existing treatments, and evaluate new ones in a network of clinical centers in North America.
- Conditions
- Anemia, Cooley's, Beta-Thalassemia, Hematologic Diseases, Thalassemia
- Trial name
- NCT00000623
- Testing
- Deferoxamine, Deferiprone, Arginine
- Where
- 5 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Carelon Research
Erectile Dysfunction
Phase 2 Efficacy Study of Sildenafil Products in Adult Men With Erectile Dysfunction
The goal of this clinical trial is to learn how different sildenafil-based erectile dysfunction (ED) treatments affect erectile function in adult men.
- Trial name
- NCT07231185
- Testing
- Hezkue, Hezkue Turbo, Galotam
- Volunteers
- 200 people
- Sponsor
- Aspargo Labs, Inc
Obesity
The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity
This is a 24-week study to evaluate the effects of two fixed-dose combinations of leucine and sildenafil or two fixed-dose combinations of leucine, sildenafil and metformin compared to placebo.
- Trial name
- NCT03364335
- Testing
- Leu Sil 1.0mg, Leu Sil 4.0mg, Leu Met Sil 1.0mg
- Where
- 15 sites in United States
- Volunteers
- 267 people
- Sponsor
- NuSirt Biopharma
Foetal Hypoxia
Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at Term
Background: Intrapartum non-reassuring foetal status is a global challenge. It is a key contributor to operative deliveries. In low- and middle-income countries, it is a major cause of perinatal deaths, hypoxic ischemic…
- Trial name
- NCT05558176
- Testing
- Sildenafil citrate
- Where
- Nigeria
- Volunteers
- 176 people
- Sponsor
- Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso
Impotence
Studying the Preference of Tadalafil to Sildenafil in Men With Problems Getting an Erection Across Nations
Study to determine if men from around the world prefer sildenafil to tadalafil.
- Trial name
- NCT00547287
- Testing
- tadalafil, sildenafil
- Where
- Brazil
- Volunteers
- 2,760 people
- Sponsor
- Eli Lilly and Company
Pulmonary Hypertension
Study to Assess the Longterm Safety of Sildenafil Citrate in Patients With Pulmonary Arterial Hypertension
Open label extension study to the pivotal efficacy study to assess the safety of sildenafil citrate in patients with pulmonary arterial hypertension
- Trial name
- NCT00159887
- Testing
- Sildenafil citrate
- Where
- 65 sites in United States, Australia and 20 more
- Volunteers
- 260 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Erectile Dysfunction
A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes.
The primary purpose of the study is to help answer whether tadalafil taken once a day can help improve the psychological outcomes (such as sexual self confidence, spontaneity and time concerns) compared to sildenafil taken as…
- Trial name
- NCT00734604
- Testing
- tadalafil once a day [T(OaD)], sildenafil citrate as needed [S(PRN)], tadalafil as needed [T(PRN)]
- Where
- 37 sites in United States, Australia and 7 more
- Volunteers
- 378 people
- Sponsor
- Eli Lilly and Company
Arterial Hypertension, Erectile Dysfunction
Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction
The study will evaluate the effects of a chronic 30-day treatment with sildenafil citrate on penile and systemic microvascular function as well as in blood pressure.
- Trial name
- NCT02620995
- Testing
- sildenafil citrate, comparator group
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Spinal Cord Injuries, Urinary Incontinence
Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries
The goal of this study is to determine whether administration of sildenafil will decrease urine leakage in patients with spinal cord injuries.
- Trial name
- NCT04565925
- Testing
- Sildenafil Citrate
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Dysmenorrhea
Viagra in the Treatment of Primary Dysmenorrhea
The primary hypothesis is that a 100mg single dose of sildenafil citrate (Viagra) will have a higher improvement rate when compared to placebo in the treatment of moderate to severe primary dysmenorrhea.
- Trial name
- NCT00123162
- Testing
- Sildenafil Citrate
- Where
- Croatia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pulmonary Hypertension
Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery
Pulmonary hypertension increases the perioperative risk in patients undergoing cardiac surgery for valvular heart diseases, especially in patients with a long life mitral valve disease.
- Trial name
- SiPaHCS (NCT01481350)
- Testing
- sildenafil
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Pulmonary Arterial Hypertension
Modulating Effects of Lisinopril on Sildenafil Activity in Pulmonary Arterial Hypertension(PAH)( MELISSA)
Patients with pulmonary arterial hypertension(PAH) suffer from chronic shortness of breath, and have impaired survival related to progressive right ventricular failure.
- Trial name
- MELISSA (NCT01181284)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
High Altitude Pulmonary Edema, Acute Mountain Sickness
Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness
The purpose of this study is to determine whether regular oral use of sildenafil citrate can prevent or attenuate high altitude illnesses.
- Trial name
- NCT00627965
- Testing
- Sildenafil citrate
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Altitude Physiology Expeditions
Heart Failure, Pulmonary Hypertension
Sildenafil in US Heart Failure Patients (SilHF-US)
This protocol describes a 2-arm randomized controlled pilot study assessing the tolerance, safety and efficacy of sildenafil compared to control.
- Trial name
- SilHF-US (NCT03460470)
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hartford Hospital
Post-Traumatic Headache
Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic Headache
To investigate whether sildenafil (phosphodiesterase 5 inhibitor) induces migraine-like headache in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).
- Trial name
- NCT05669885
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Erectile Dysfunction
Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction
The purpose of this study is to investigate the effect of up to 200 mg of PF-00446687 on erectile activity in males suffering from erectile dysfunction as well as examining the safety and toleration of the drug.
- Trial name
- NCT00862888
- Testing
- PF-00446687, Sildenafil
- Where
- 3 sites in Norway, United Kingdom
- Volunteers
- 39 people
- Sponsor
- Pfizer
Cancer
Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment
This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome.
- Trial name
- SPARC (NCT06800092)
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Medical Branch, Galveston