Clinical trials: Sildenafil
Erectile Dysfunction
Satisfaction, Confidence and Naturalness in Men With Psychogenic Erectile Dysfunction (ED)
Context and Objectives: Erectile dysfunction severely compromises not only sexual satisfaction, which is well known to be closely linked to overall life satisfaction but is also associated with a lower quality of life, lower…
- Trial name
- NCT01153204
- Testing
- Group Psychotherapy, Group Psychotherapy plus Sildenafil citrate, Sildenafil citrate
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Sildenafil, Sleep Apnea
The Effect of Sildenafil on Sleep-Disordered Breathing in Obese Patients With Sexual Dysfunction
Sildenafil has been shown to aggravate sleep-disordered breathing in patients with severe obstructive sleep apnea. The aim of the present study is to examine the frequency of sleep-disordered breathing in obese patients who are…
- Conditions
- Sildenafil, Sleep Apnea, Sexual Dysfunction, Obesity
- Trial name
- NCT00893191
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Thalassemia
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension
This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia
- Trial name
- NCT03402191
- Testing
- L-arginine, Sildenafil
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sherief Abd-Elsalam
Pulmonary Arterial Hypertension
Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study
In an earlier study, sildenafil citrate administered to patients of PAH led to improvement in pulmonary arterial pressure, cardiac output, quality of life, and other parameters as compared to placebo.
- Trial name
- UK 92480 (NCT00878943)
- Testing
- Sildenafil citrate
- Where
- 5 sites in India
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Brain Tumor
Asciminib With or Without Sildenafil for Brain Tumors
Dissemination of medulloblastoma is an independent risk factor of poor prognosis. Dissemination of medulloblastoma at recurrence is nearly universally fatal.
- Trial name
- NCT07039760
- Testing
- Asciminib, Sildenafil, Surgical resection or biopsy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
Scleroderma, Systemic, Scleroderma, Diffuse
Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis
Early phases of systemic sclerosis is characterized by inflammatory and microvasculature alterations. Sildenafil citrate has been shown to have vasodilatory effects and to enhance vasculogenesis.
- Conditions
- Scleroderma, Systemic, Scleroderma, Diffuse, Scleroderma, Limited, Raynaud Phenomenon
- Trial name
- NCT01347008
- Testing
- Sildenafil citrate
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Federal University of São Paulo
Erectile Dysfunction
Phase 2a Topical Sildenafil Proof-of-Concept Study in Men With Mild to Moderate ED
This is a Phase 2a, single-dose, double-blind, placebo-controlled, 2-way crossover study in men with ED. A single 2 gram dose of SST-6006 topical cream 5% w/w (formulated to deliver 100 mg of sildenafil) or a topical placebo…
- Trial name
- NCT02390960
- Testing
- Sildenafil Cream, Penile Plethysmography (RigiScan)
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Strategic Science & Technologies, LLC
Peripheral Arterial Disease
Reduced Cardiovascular Morbi-mortality by Sildenafil in Patients With Arterial Claudication
Sildenafil has shown potential effects both on vasodilator mechanisms and as an inhibitor of the NO/GMPc Pain activation. The investigators aim at estimating the benefit of sildenafil in term of morbi-mortality in patients with…
- Trial name
- NCT02387450
- Testing
- Sildenafil
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Angers
Erectile Dysfunction
Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males
In clinical practice it is quite common to have sexually active male patients with mild/normal erectile function that are not satisfied with their sexual function.
- Trial name
- NCT00313898
- Testing
- sildenafil (viagra)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Choroidal Ischemia, Vitelliform Macular Dystrophy
Sildenafil for Treatment of Choroidal Ischemia
The hypothesis of this study is to determine if there is a benefit afforded by the use of systemic Sildenafil to patients with choroidal and retinal degenerations and dystrophies, such as vitelliform degeneration, dry and…
- Conditions
- Choroidal Ischemia, Vitelliform Macular Dystrophy, Age-related Macular Degeneration, Central Serous Retinopathy
- Trial name
- NCT04356716
- Testing
- Sildenafil, Standard of Care Sildenafil, Ocular Coherence Tomography-Angiography (OCT-A)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Eisenmenger Syndrome
Combination Treatment With Bosentan and Sildenafil to Patients With Eisenmengers Syndrome
The purpose of this study is to investigate if combination treatment with Bosentan and Sildenafil to patients with Eisenmenger syndrome is beneficial.
- Trial name
- NCT00303004
- Testing
- Bosentan and Sildenafil
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Impotence
A Randomized Double Blind, Placebo Controlled Balanced 4-Way Crossover Study To Assess The Efficacy Of Single Oral Doses
The primary aim of this study is to assess how effective PF-00592379 is in restoring penile erections in patients with erectile dysfunction.
- Trial name
- NCT00273416
- Testing
- PF-00592379, Sildenafil 100mg
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Pfizer
Pulmonary Hypertension
Evaluation of the Pharmacodynamic Effect of the Combination of Sildenafil and Riociguat on Blood Pressure and Other Safety Parameters.
Pulmonary Arterial Hypertension (PAH) is a severe progressive disease with a high mortality. Although several drugs are available for the treatment of PAH none offer a cure, therefore there is still a high medical need for new…
- Trial name
- PATENT PLUS (NCT01179334)
- Testing
- Riociguat (Adempas, BAY63-2521), Sildenafil
- Where
- 25 sites in United States, Austria and 7 more
- Volunteers
- 18 people
- Sponsor
- Bayer
COPD, Pulmonary Hypertension
Sildenafil for Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension
Chronic obstructive pulmonary disease (COPD)can be complicated by an increased pressure in the pulmonary circulation. This worsens the prognosis, but so far it is unknown whether treatment of the increased pulmonary blood…
- Trial name
- NCT00730067
- Testing
- sildenafil
- Where
- 2 sites in Denmark
- Sponsor
- University of Aarhus
Prostate Cancer, Male Erectile Disorder
ED Recovery in Men Age </=65 Treated With Bilateral Nerve Sparing Robotic Assisted Prostatectomy for Prostate Cancer
RATIONALE: Sildenafil citrate and alprostadil may help patients who have undergone prostatectomy for prostate cancer to recover from erectile dysfunction.
- Conditions
- Prostate Cancer, Male Erectile Disorder, Stage I Prostate Cancer, Stage II Prostate Cancer
- Trial name
- NCT00544076
- Testing
- sildenafil citrate, alprostadil, robotic-assisted laparoscopic surgery
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- City of Hope Medical Center
Erectile Dysfunctions, Healthy Volunteer
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Viaca (Sildenafil + Cabergoline) Compared With Sildenafil and Cabergoline
This is a Phase 1, open-label, single-ascending-dose study evaluating the safety, tolerability, and pharmacokinetics (PK) of Viaca - a fixed-dose oral combination of sildenafil (a PDE5 inhibitor) and cabergoline (a dopamine D2…
- Trial name
- NCT07732387
- Testing
- Viaca, Sildenafil 50 mg, Cabergoline 0.5 MG
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yanping Kong
Infertility, Female
Sildenafil and Outcome of IVF/ICSI Cycles
Adequate growth of the endometrium is crucial for implantation. Accordingly, the pregnancy success rate of patients with a thin endometrium is low.
- Trial name
- NCT03192709
- Testing
- Sildenafil vaginal suppositories
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Waldenstrom's Macroglobulinemia
Sildenafil Citrate in Waldenstrom's Macroglobulinemia
The purpose of this study is to determine the effects (good or bad) that sildenafil (Viagra) has on patients with slow growing Waldenstrom's macroglobulinemia (WM).
- Trial name
- NCT00165295
- Testing
- Sildenafil citrate (Viagra)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Healthy Volunteers
Bioavailability of 3 Sildenafil Oral Disintegrating Tablet Formulations Compared to the Standard Oral Tablet
The bioavailability of the oral disintegrating tablet formulations given without water will be similar to an equivalent dose of the standard oral tablet given with water.
- Trial name
- NCT00950404
- Testing
- Viagra 50 mg tablet, Formulation B ODT tablet 50 mg, Formulation C ODT tablet 50 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Recurrent Abortion
Sildenafil Citrate and Recurrent Abortion
Two groups of unexplained recurrent spontaneous abortion, each included 65 participants. scheduled randomly into; the study group received Sildenafil Citrate and Placebo group.
- Trial name
- NCT03475160
- Testing
- Sildenafil Citrate vaginal suppositories, Uterine artery Doppler before treatment, Uterine artery Doppler after treatment
- Volunteers
- 130 people
- Sponsor
- Benha University