Clinical trials: Sildenafil, completed
Active Digital Ulcers
Sildenafil for Treatment of Digital Ulcers in Patients With Systemic Sclerosis
This is a pilot study analyzing the effect of sildenafil therapy on digital ulcers in systemic sclerosis. We want to analyze ulcer healing by measuring the size of digital ulcers and their count and analyze the effect of…
- Trial name
- Sildenafil (NCT00624273)
- Testing
- Sildenafil therapy
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Charite University, Berlin, Germany
Lymphatic Malformations, Lymphatic Diseases
Sildenafil for the Treatment of Lymphatic Malformations
A Phase 2 study to evaluate safety and efficacy of sildenafil taken orally to improve or resolve lymphatic malformations in children.
- Trial name
- NCT02335242
- Testing
- Sildenafil 20 mg tablets
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Stanford University
Fatigue
The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body…
- Trial name
- NCT01661595
- Testing
- Sildenafil, tadalafil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Impotence
Study to Determine a Preference Between Sildenafil or Tadalafil Treatment for Problems Getting an Erection
To determine if men with problems getting and keeping an erection prefer treatment with tadalafil or sildenafil.
- Trial name
- NCT00547352
- Testing
- tadalafil, sildenafil
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Eli Lilly and Company
Erectile Dysfunction, Diabetes Mellitus, Type 2
A Multicenter, Double-blind Study to Evaluate the Effect of Pretreatment With a Daily Dose of Sildenafil on the As-Needed Efficacy of Viagra in Men With Erectile Dysfunction and Type 2 Diabetes
To determine the effect on erectile function in a population of type 2 diabetic men with erectile dysfunction who have undergone the following treatment regimen: pre-treatment with a daily dose of double-blind sildenafil versus…
- Trial name
- NCT00645268
- Testing
- sildenafil
- Where
- 29 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Impotence, Depression
Efficacy Study Measuring The Impact Of Treatment With Viagra On The Depressive Symptoms Of Men With Erectile Dysfunction
This study will measure the impact of treatment with Viagra on the depressive symptoms and quality of life in men with erectile dysfunction who have untreated depressive symptoms meeting the DSM-IV criteria for dysthymia or…
- Trial name
- NCT00159809
- Testing
- Viagra (Sildenafil citrate)
- Volunteers
- 140 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Erectile Dysfunction
A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo Controlled, Flexible Dose Escalation Study To Evaluate Sexual And Relationship Satisfaction In The Female Partner Of Men With Erectile Dysfunction Treated With Sildenafil Citrate
To compare the effects of sildenafil versus placebo on the female partner's sexual satisfaction as assessed by Question 3 of Female Partner of Erectile Dysfunction (ED) Subject Questionnaire (FePEDS-Q): "Over the past 4 weeks…
- Trial name
- NCT00644631
- Testing
- sildenafil
- Where
- 31 sites in United States
- Volunteers
- 300 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Fetal Distress, Perinatal Asphyxia
Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of…
- Conditions
- Fetal Distress, Perinatal Asphyxia, Birth Asphyxia, Stillbirth
- Trial name
- PRISM (NCT05946681)
- Where
- Zambia
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Erectile Dysfunction
Radial Shockwave Therapy for Erectile Dysfunction
Objective: To evaluate the efficacy and safety of radial shock waves for the treatment of erectile dysfunction [ED]. Patients and methods: Randomized, double-blind clinical trial.
- Trial name
- NCT03596047
- Testing
- Radial wave therapy
- Where
- Colombia
- Volunteers
- 80 people
- Sponsor
- Boston Medical Group
Pregnancy Complication
Effect of Sildenafil Citrate on Uteri- Placental Perfusion, Doppler Indices in Growth Restricted Fetuses
To detect the effect of sildenafil citrate on Doppler parameters in fetuses suffering from growth restriction to support its use later as prolonged therapy in those pregnancies at higher risk for such complication.
- Trial name
- NCT02362399
- Testing
- sildenafil citrate
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Al Hayat National Hospital
Infertility, Female
Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness
One hundred thirty women with unexplained infertility participated in a prospective clinical study. Patients were assigned at random to one of two groups.
- Trial name
- NCT05846906
- Testing
- Sildenafil Citrate, Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Pulmonary Arterial Hypertension
Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension
To assess the efficacy and safety of sildenafil when added to patients with PAH who are taking bosentan as all or part of their background therapy.
- Trial name
- NCT00323297
- Testing
- Bosentan, Sildenafil Citrate
- Where
- 30 sites in United States, Australia and 8 more
- Volunteers
- 105 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hand Foot Syndrome, Palmar Plantar Erythrodysesthesia
Treatment of Palmar Plantar Erythrodysesthesia (PPE) With Topical Sildenafil
Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysethesia (PPE), occurs in a 25%-50% of patients treated with several commonly used anti-cancer drugs including capecitabine and sunitinib.
- Trial name
- JADE (NCT01219023)
- Testing
- sildenafil citrate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Pulmonary Hypertension
Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan)
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00666198
- Testing
- SILDENAFIL
- Volunteers
- 3,337 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pulmonary Hypertension, Familial Persistent, of the Newborn
A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
This study will evaluate whether IV sildenafil can reduce the time on inhaled nitric oxide treatment and reduce the failure rate of available treatments for persistent pulmonary hypertension of the newborn.
- Trial name
- NCT01720524
- Testing
- iv sildenafil
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 59 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Heart Failure NYHA Class II
The Effect of Combination of Dapagliflozin and Sildenafil in Treatment of Heart Failure Patients With Secondary Pulmonary Hypertension
This study aims to determine the efficacy of sildenafil (improve PAH) as an add-on therapy to dapagliflozin in the treatment of heart failure patients with secondary pulmonary arterial hypertension and compare the result with…
- Trial name
- NCT06778330
- Testing
- Dapagliflozin (DAPA), Sildenafil
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Fayoum University
Insulin Resistance, Endothelial Dysfunction
CD36 in Nutrient Delivery and Its Dysfunction
This proposal will test the hypothesis that chronic treatment with sildenafil with and without the use of nitric oxide substrate, L-arginine, protects against fatty acid induced impairment of endothelial function, improves…
- Trial name
- NCT03012386
- Testing
- Sildenafil Citrate in G allele carrier, Sildenafil Citrate in non G allele carrier
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure
Chronic Sildenafil Treatment in Heart Failure
In heart failure (HF), a defective nitric oxide (NO) signaling may be involved in left ventricular (LV) diastolic abnormalities and LV remodelling progression.
- Trial name
- NCT00975494
- Testing
- Sildenafil
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Alopecia Areata
A Novel Formulation of Sildenafil-loaded Nanocarriers for Treatment of Alopecia Areata
Alopecia areata (AA) is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Many theories were implicated in pathogenesis of AA, such as an autoimmune lymphocytic attack of the hair…
- Trial name
- NCT06527729
- Testing
- sildenafil-loaded liposomes, minoxidil gel
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Assiut University