Clinical trials: Simvastatin, completed
Hypercholesterolemia, Diabetes
Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients?
We aimed to address the issue whether statins affect insulin resistance. To this end, we combined the available state-of-the art technology for detailed assessment of both whole-body and tissue specific insulin sensitivity in…
- Conditions
- Hypercholesterolemia, Diabetes, Cardiovascular Disease
- Trial name
- NCT00704314
- Testing
- Simvastatin
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Healthy Volunteers
A Study to Assess Co-Administered AZD9056 (Steady State) and Simvastatin (Single Dose) in Healthy Volunteers
The purpose of the study is to assess the pharmacokinetics of both AZD9056 (steady state) and simvastatin (single dose) when co-administered in healthy volunteers
- Trial name
- NCT00736606
- Testing
- simvastatin, AZD9056 + simvastatin
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Drug Distribution
Statin Distribution
Anticipating an increased use of statins in children and adolescents, it is imperative that we understand the genetic and developmental characteristics affecting the pharmacokinetics and pharmacodynamics of statins in childhood…
- Trial name
- NCT02360826
- Testing
- Pravastatin, Simvastatin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Type 2 Diabetes Mellitus
Study To Assess the Pharmacokinetics of AZD1656 During Coadministration With Simvastatin
To assess the pharmacokinetics of AZD1656 during coadministration with Simvastatin.
- Trial name
- NCT01096940
- Testing
- AZD1656, simvastatin
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- AstraZeneca
Cardiovascular Disease
Polypill For Prevention of Cardiovascular Disease
The purpose of this pilot study is to provide data on the feasibility of conducting a large clinical trial on the polypill (combination of aspirin, angiotensin converting enzyme inhibitor, thiazide diuretic, and statin) for…
- Trial name
- NCT00567307
- Testing
- Red Heart Pill 2b (Polypill), Standard Practice
- Where
- 3 sites in Sri Lanka
- Volunteers
- 216 people
- Sponsor
- Wake Forest University Health Sciences
Periodontal Diseases
Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
The purpose of this study is to determine of local application of commericially-available, FDA-approved preparation of simvastatin is effective in increasing clinical attachment levels (primary outcome), as well as alveolar bone…
- Trial name
- NCT03452891
- Testing
- Methylcellulose, Simvastatin-Methylcellulose
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Alzheimer's Disease
Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease
The purpose of the research is to see how simvastatin affects a substance in the body called beta-amyloid. Beta-amyloid is found in the brain and in the liquid around the brain and spinal cord.
- Trial name
- SHARP (NCT00939822)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Chronic Obstructive Pulmonary Disease
The Effect of Statins in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a condition of the lungs which results in breathing difficulties due to the lungs becoming inflamed and the airways narrowed.
- Trial name
- NCT01151306
- Testing
- Simvastatin, Lactose tablet
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Nottingham
Diabetes Mellitus, Type 2
Glucagon-like Peptide (GLP) Utilization and Safety
This study will assess the utilization patterns (adherence, source of the index antidiabetic agent (ADA) and treatment modification) of the marketed glucagon-like peptide-1 (GLP-1) receptor agonists (exenatide and liraglutide)…
- Trial name
- NCT01767389
- Testing
- The GLP-1 receptor agonist users, DPP-4 inhibitor users, Other ADA users
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Hypercholesterolemia
Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.
The purpose of the study is to determine the efficacy of lapaquistat acetate, once daily (QD), taken with simvastatin on cholesterol levels in subjects with primary dyslipidemia
- Trial name
- NCT00256178
- Testing
- Lapaquistat acetate and simvastatin, Simvastatin
- Where
- 53 sites in Czechia, Estonia and 5 more
- Volunteers
- 411 people
- Sponsor
- Takeda
Fredrickson Type IIa & Type IIb Dyslipidaemia
IIIb 6 Week Open Label Multicentre Rosuvastatin & Simvastatin
The purpose of this study is to assess the effects on the kidney of rosuvastatin and simvastatin in subjects with Fredrickson Type IIa \& Type IIb Dyslipidaemia
- Trial name
- NCT00654446
- Testing
- Rosuvastatin, Simvastatin
- Volunteers
- 442 people
- Sponsor
- AstraZeneca
Dyslipidemia
Efficiency of Rosuvastatin Versus the Fixed Combination of Ezetimibe/Simvastatin in Outpatients
The aim of this study is to evaluate the effectiveness of Rosuvastatin versus Ezetimibe/Simvastatin in dyslipidemic patients treated for at least 8 weeks.
- Trial name
- NCT01164397
- Where
- 9 sites in Mexico
- Volunteers
- 268 people
- Sponsor
- AstraZeneca
Type 2 Diabetes, Inflammation
Effects on NF-κB Activity: High Dose Simvastatin Versus Combination Therapy With Ezetimibe
Lowering LDL cholesterol by statins has been proven to be associated with reduction of proinflammatory regulators e.g. activation of the transcription factor NF-ĸB.
- Trial name
- NCT01424891
- Testing
- Simvastatin 80 mg, Sim10/Eze10
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Heidelberg University
Hyperlipidemia
LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2
The primary objective was to evaluate the effect of 12 weeks of evolocumab administered subcutaneously every 2 weeks (Q2W) and monthly (QM) when used in combination with a statin, compared with placebo, on percent change from…
- Trial name
- LAPLACE-2 (NCT01763866)
- Testing
- Evolocumab, Ezetimibe, Atorvastatin
- Where
- 244 sites in United States, Australia and 19 more
- Volunteers
- 2,067 people
- Sponsor
- Amgen
Postprandial Lipemia, Type 2 Diabetes
Ezetimibe and Statins on Postprandial Lipemia in Type 2 Diabetes
The purpose of this study is to determine whether ezetimibe in association with statins is more effective than statins alone on postprandial lipemia in type 2 diabetic patients.
- Trial name
- EZE (NCT00699023)
- Testing
- ezetimibe tablets, simvastatin tablets
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Federico II University