Clinical trials: Standard treatment
Diabetes Mellitus Self Management Education
Optimizing Care for Diabetic Patients in Hospitalized Rehabilitation Through Structured Education
A large number of patients at the Neurological and Functional Rehabilitation Centre of the University Hospital of Liège have associated pathologies, including diabetes.
- Trial name
- NCT06916871
- Testing
- The control group will benefit from awareness, The experimental group will benefit from structured education which will be carried out by the diabetes nurse
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Corneal Neovascularization
Corneal Crosslinking for Treatment of Corneal Neovascularization
The study objective is to assess safety and efficacy of photo-activation of riboflavin for treatment of corneal neovascularization with or without concomitant inflammation and/or infection.
- Trial name
- NCT04787471
- Testing
- 30 minute photoactivation of riboflavin 0.1%, 10 minute photoactivation of riboflavin 0.1%
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Price Vision Group
Asthma, Asthma Patients
The Effect of Thyme Oil in Asthmatic Patients
This study is a pre-test post-test randomized controlled trial aimed at examining the effects of thyme oil inhalation on asthma control and respiratory parameters in patients with asthma.
- Trial name
- NCT06664671
- Testing
- Experimental, Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Inonu University
Compensated Advanced Chronic Liver Disease, Varices Needing Treatment
CHESS Criteria for Varices Screening in Compensated Advanced Chronic Liver Disease (CHESS2001/APPHA2001)
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices in cACLD, esophagogastroduodenoscopy (EGD) should be performed.
- Trial name
- NCT04307264
- Testing
- Esophagogasrtoduodendoscopy, liver stiffness measurement
- Where
- 15 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Health Care Associated Infection, Hand Hygiene
Reducing Intraoperative Infection Transmission in the Pediatric Operating Room
Patients becoming infected during hospitalization occurs frequently and causes harm. It is important for healthcare facilities to take action to prevent these infections and their spread between patients.
- Trial name
- NCT03992209
- Testing
- Standard care, Protocolized care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ischemic Cardiomyopathy, Cell Therapy
Safety and Efficacy of FAP iCDC in Ischemic Cardiomyopathy
This study aims to evaluate the safety and efficacy of fibroblast activation protein (FAP)-targeted autologous immunosuppressive chimeric antigen receptor dendritic cell (iCDC) therapy in patients with ischemic cardiomyopathy…
- Trial name
- NCT07505199
- Testing
- autologus FAP-targeted immunosuppressive CAR-DCs (iCDC), Standard medical treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nerve Block/Methods
Comparing Suprascapular Nerve Block and Interscalene Block for Post-thoracotomy Pain in Pediatric Patients.
The goal of this clinical trial is to determine which regional block provides superior analgesia in pediatric patients undergoing thoracic surgery.
- Trial name
- NCT07796399
- Testing
- Interscalene brachial plexus block, anterior Supraclavicular nerve block, Thoracic Epidural Analgesia (TEA) only
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Lung Cancer
Evidence-Based Nursing for Fatigue and Quality of Life in Lung Cancer Chemotherapy
This prospective randomized controlled trial investigated the effects of an evidence-based nursing intervention under a quantitative assessment strategy (EB-NQAS), utilizing the Edmonton Symptom Assessment Scale (ESAS), on…
- Trial name
- NCT07049237
- Testing
- Evidence-Based Nursing Under Quantitative Assessment Strategy (EB-NQAS), Routine Nursing Care
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Hospital of Hebei Medical University
Overactive Bladder (OAB), Urinary Urgency
APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women
The APPROVE trial is a multi-centered, randomized controlled trial designed to assess differences in symptom improvement, quality of life, bladder symptoms, satisfaction with treatment and continued treatment efficacy in women…
- Conditions
- Overactive Bladder (OAB), Urinary Urgency, Urinary Urge Incontinence (UUI), Nocturia
- Trial name
- APPROVE (NCT06797245)
- Testing
- RiSolve App, AUGS Patient Handouts
- Where
- 10 sites in United States
- Volunteers
- 596 people
- Sponsor
- Medstar Health Research Institute
Brain Metastases, Adult
A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases
This is a research study to determine if performing stereotactic radiosurgery (SRS) prior to surgical resection of the brain metastasis (tumor) will improve local control, in other words, increase the possibility of total removal…
- Trial name
- NCT05341739
- Testing
- Pre-operative Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Esophageal Adenocarcinoma
Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
The goal of this trial is to learn if adding consolidative chemotherapy to routine chemoradiation can better control both local recurrence and metastasis and reduce the need for surgical intervention.
- Trial name
- TNT Esophagus (NCT07603375)
- Testing
- FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Acne Vulgaris
Impact of Isotretinoin in Different Doses on Quality of Life
The Cardiff Acne Disability Index is a short five-item questionnaire derived from the longer Acne Disability Index.It is designed for use in teenagers and young adults with acne.
- Trial name
- NCT05316675
- Testing
- Isotretinoin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heavy Menstrual Bleeding, Abnormal Uterine Bleeding
A Registry to Gather Real World Use Data on the Cerene® Cryotherapy Device
Channel Medsystems, Inc., the manufacturer of the Cerene® Cryotherapy Device (Cerene), is initiating a prospective, observational registry, the Progress registry, to gather data during real world utilization of the Cerene®…
- Conditions
- Heavy Menstrual Bleeding, Abnormal Uterine Bleeding, Menorrhagia
- Trial name
- Progress (NCT05922657)
- Testing
- Cerene
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Channel Medsystems
Breast Cancer, Postoperative Pain
Liposomal Bupivacaine in Implant Based Breast Reconstruction
Objectives: 1. To evaluate the effect of liposomal bupivacaine on postoperative pain levels. 2. To evaluate the effect of liposomal bupivacaine on postoperative opioid consumption and opioid related adverse events. 3.
- Trial name
- NCT02659501
- Testing
- Liposomal bupivacaine, Bupivacaine with epinephrine, Morphine sulfate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Loma Linda University
Cancer, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Electroacupuncture and Exercise for Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment that causes numbness, pain, and balance issues in a patient's hands and feet.
- Trial name
- EA-EX CIPN (NCT07700901)
- Testing
- Electroacupuncture, Exercise Training, Structured Home-Based Health Education and Dose-Controlled Exercise Program
- Where
- 2 sites in Taiwan
- Volunteers
- 82 people
- Sponsor
- Show Chwan Memorial Hospital
Multiple Myeloma, Triple Negative Breast Cancer
Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null Phenotype
This study is comprised of a main study, an observational study, and optional survey studies. The main study is being done to see whether using Duffy null specific treatment dosing guidelines can reduce or delay dose…
- Conditions
- Multiple Myeloma, Triple Negative Breast Cancer, Duffy Blood Group, Chemokine Receptor Gene Mutation, Duffy Blood Group, Chemokine Receptor Gene C.-67T>C
- Trial name
- NCT07341867
- Testing
- Dexamethasone, Bortezomib, LENALIDOMIDE
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Andrew Hantel, MD
Ovarian Cancer
Phase Ib/II Study of Carboplatin + M6620 + Avelumab in PARPi-resistant Ovarian Cancer
The study was to evaluate the efficacy and safety of avelumab in combination with M6620 + carboplatin in participants with PARPi-resistant, recurrent, platinum sensitive ovarian, primary peritoneal, or fallopian tube cancer.
- Trial name
- NCT03704467
- Testing
- M6620, Avelumab, Carboplatin
- Where
- 13 sites in United States, Belgium and 1 more
- Volunteers
- 3 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Hepatitis C, Liver Inflammation
Treatment of HOsPitalised Inpatients for Hepatitis C (TOPIC): Therapeutic Intervention Enhancing Care Linkage in People Who Inject Drugs
This study will evaluate the proportion of patients achieving confirmed SVR12 (undetectable HCV RNA at time point 12 weeks plus post treatment commencement) in patients hospitalised for IRID (injecting related infectious…
- Conditions
- Hepatitis C, Liver Inflammation, Liver Cirrhoses
- Trial name
- TOPIC (NCT03981211)
- Testing
- Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet, Sofosbuvir 400 MG + Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet
- Where
- 7 sites in Australia
- Volunteers
- 21 people
- Sponsor
- Kirby Institute
Schizophrenia, Cognition Disorders
The Effect of Nicotine on Arousal, Cognition and Social Cognition in Schizophrenic Patients
This study in patients with stable schizophrenia will investigate the effect of nicotine on arousal, cognitive task and social cognition after acute dose administration.
- Trial name
- NCT01186471
- Testing
- A643 (nicotine)
- Volunteers
- 32 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
COPD
Study to Evaluate the Efficacy and Safety of Glycopyrronium or Indacaterol Maleate and Glycopyrronium Bromide Fixed-dose Combination Regarding Symptoms and Health Status in Patients With Moderate COPD Switching From Treatment With Any Standard COPD Regimen
The main goal of this study is to evaluate the efficacy and safety of glycopyrronium bromide and indacaterol maleate and glycopyrronium bromide fixed dose combination (FDC) in patients with moderate COPD who switch from their…
- Trial name
- NCT01985334
- Testing
- Glycopyrronium, SABA, LABA
- Where
- 542 sites in Austria, Belgium and 21 more
- Volunteers
- 4,389 people
- Sponsor
- Novartis Pharmaceuticals
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