Clinical trials: Standard treatment
Amputation Stumps, Pain
Enriched Autologous Fat Grafting for Treating Pain at Amputation Sites
The objective of this pilot study is to assess the efficacy of minimally invasive autologous fat transfers at the amputation sites and the modulation of pain at the respective sites.
- Trial name
- AMP-5 (NCT01645722)
- Testing
- Procedure/Surgery: Enriched Fat grafting
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Rectal Cancer
Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic Cancers
Patients with locally advanced non-metastatic adenocarcinoma of the rectum undergoing chemoradiation therapy will be assigned to 2 groups: the intervention group will be prescribed an individualized ketogenic eating plan to be…
- Trial name
- KOMPARC (NCT05938322)
- Testing
- Ketogenic Diet, Standard Diet
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Cancer
Combination Chemotherapy Followed by Radiation Therapy in Patients With Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug is a way to kill more tumor cells.
- Trial name
- NCT00002822
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Medical Research Council
Meningitis Streptococcal, Hiv
Treatment With Tamoxifen in Cryptococcal Meningitis
The purpose of this study is to develop initial efficacy, feasibility, and safety data regarding the use of Tamoxifen in combination with amphotericin B and fluconazole in the treatment of cryptococcal meningitis.
- Conditions
- Meningitis Streptococcal, Hiv, Meningitis, Meningoencephalitis
- Trial name
- NCT03112031
- Testing
- Tamoxifen, Amphotericin B, Fluconazole
- Where
- 3 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Duodenal Adenoma
Endoscopic Resection of Non-ampullary Duodenal Adenomas: Endoscopic Mucosal Resection (EMR) vs. Endoscopic Full-thickness Resection With the 'Duodenal Full-thickness Resection Device' (dFTRD)
Prospective, randomized multi-center trial. Comparison of Endoscopic Mucosal Resection (EMR) versus Endoscopic Full-Thickness Resection with the duodenal Full-Thickness Resection Device (dFTRD) of non-ampullary duodenal adenomas.
- Trial name
- DUO-RESECT (NCT03559231)
- Testing
- dFTRD, EMR
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Opioid Use Disorder
Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department
Project Summary The goal of this pilot clinical trial is to assess contingency management (CM) for increasing attendance at outpatient clinics after Medication for Opioid Use Disorder (MOUD) prescription and clinic referral…
- Trial name
- CM+ED+MOUD (NCT07129902)
- Testing
- Contingency Management, Usual care as prescribed by the ED physicians
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Vermont
Overactive Bladder, Obstructive Sleep Apnea
Tolterodine Relieves Overactive Bladder Symptoms in Women With Moderate-to-severe Obstructive Sleep Apnea Syndrome
In this study, we aim to determine whether combined tolterodine and CPAP therapy is a more effective treatment for patients with OSAS than CPAP treatment only.
- Conditions
- Overactive Bladder, Obstructive Sleep Apnea, Overactive Bladder Syndrome
- Trial name
- NCT05250245
- Testing
- Tolterodine Tartrate 4 MG, Continuous positive airway pressure therapy (CPAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Congestive Heart Failure
BNP Therapy Observation Unit Outcomes STudy (BOOST)
The investigators hypothesize that patients admitted to an emergency department (ED) observation unit will have a decreased rate of hospital admissions and ED recidivism when treated with nesiritide versus standard therapy.
- Trial name
- BOOST (NCT00453453)
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Emory University
Acute Myocardial Infarction, Ticagrelor
Optimal Dosage of Ticagrelor in Korean Patients With AMI
East Asian patients will be required optimal dose of newer P2Y12 inhibitor (ticagrelor) to determine the safer treatment and better outcome.
- Trial name
- NCT05210595
- Testing
- Clopidogrel 75 mg, Ticagrelor 60mg, Ticagrelor 45 mg
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Dong-A University
Coronary Artery Disease Progression
Intensive Lipid-lowering for Plaque and Major Adverse Cardiovascular Events in Low to Intermediate 10-year ASCVD Risk Population
Current guidelines recommend moderate-intensity lipid-lowering therapy (goal for LDL-C <2.6 mmol/L or 30%-50% reduction from baseline) for patients with intermediate 10-year ASCVD risk.
- Trial name
- ILLUMINATION (NCT05462262)
- Testing
- Intensive lipid-lowering control, Moderate-intensity lipid-lowering control
- Where
- China
- Volunteers
- 2,900 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ischemic Stroke
Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke
Patients presenting to the emergency department with acute ischemic stroke, who are are eligible for standard intravenous tPA therapy within 4.5 hours of stroke onset will be assessed for major vessel occlusion to determine their…
- Trial name
- EXTEND-IA TNK (NCT02388061)
- Testing
- Tenecteplase, Tissue Plasminogen Activator
- Where
- 18 sites in Australia, New Zealand
- Volunteers
- 202 people
- Sponsor
- Neuroscience Trials Australia
Wet Macular Degeneration, Cataract Extraction
Management of Patients With Neovascular Age-related Macular Degeneration Undergoing Cataract Surgery
To-date there have been only very few studies to examine the effect of cataract surgery to patients with wet age-related macular degeneration.
- Trial name
- NCT03944070
- Testing
- Ranibizumab
- Where
- Greece
- Volunteers
- 16 people
- Sponsor
- Ophthalmica Eye Institute
Caries, Dental Pulp Exposure
Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Background: Dental caries is considered an oral health problem worldwide. In Chile the last national epidemiological study (2007) showed a national prevalence of dental caries in children 6 years (70.3%) and 12 (62.5%).
- Trial name
- NCT02492841
- Testing
- Mineral trioxide aggregate, Calcium hydroxide, Biodentine
- Where
- Chile
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Acne Vulgaris
A Study of the Safety, Engraftment, and Action of Multi-Dosed NB01 in Adults With Moderate Acne
Acne vulgaris is a disease caused my multiple factors including overgrowth of bacteria, clogged pores, excessive sebum production and hormonal changes.
- Trial name
- NCT03709654
- Testing
- NB01, Vehicle Control
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Naked Biome, Inc.
Extensive Small Cell Lung Cancer
Adebelizumab Combined With Chemotherapy and Radiotherapy Treat ES-SCLC
To observe the efficacy and safety of adebelizumab combined with chemotherapy and sequential adebelizumab combined with radiotherapy in the treatment of newly diagnosed extensive small cell lung cancer.
- Trial name
- NCT06125041
- Testing
- Adebelizumab+Carboplatin+Etoposide+Concurrent Radiotherapy
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Qianfoshan Hospital
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Clostridium Difficile Infection
Safety and Efficacy of DAV132 in Patients at High-Risk for Clostridium Difficile Infection (CDI)
The purpose of this study is to determine the safe use and evaluate the efficacy/performance of DAV132 in hospitalized patients at high risk for Clostridium difficile infection (CDI) and who receive fluoroquinolones (FQs) for the…
- Trial name
- SHIELD (NCT03710694)
- Testing
- DAV132
- Where
- 29 sites in Bulgaria, Germany and 2 more
- Volunteers
- 260 people
- Sponsor
- Da Volterra
Posterior Synechiae of Iris
Mydriatic Drops After Combined Surgery
The study goal is to evaluate the influence of mydriatic drops on the development of posterior synechia after combined cataract and vitrectomy surgery.
- Trial name
- NCT05614622
- Testing
- Cyclopentolate Hydrochloride 1.0% eye drops
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Type 2, Cardiac Surgery
Dapagliflozin Therapy In Cardiac Surgery
This randomized controlled trial is to assess the effects of perioperative dapagliflozin on type 2 diabetic patients undergoing cardiac surgery
- Trial name
- NCT05621551
- Testing
- Dapagliflozin
- Where
- China
- Volunteers
- 178 people
- Sponsor
- China National Center for Cardiovascular Diseases
Peri-Implantitis
Prevention of Dental Implant Diseases
The aim of this study is to determine the effect of regular antibacterial photodynamic Lumoral® treatment on gingival health and plaque volume, and anti-inflammatory effect of daily double light therapy on implant teeth.
- Trial name
- NCT05871229
- Testing
- Lumoral Treatment, Standard treatment for peri-implantitis
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Hanna Lähteenmäki
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