Clinical trials: Standard treatment
Acute Myelogenous Leukemia, Myelogenous Leukemia
Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML)
This is a Phase 1b, open-label, non-randomized, multicenter study to evaluate the safety and pharmacokinetics of orally administered venetoclax (ABT-199) combined with decitabine or azacitidine and the preliminary efficacy of…
- Conditions
- Acute Myelogenous Leukemia, Myelogenous Leukemia, Treatment Naive AML
- Trial name
- NCT02203773
- Testing
- Posaconazole, ABT-199, Decitabine
- Where
- 23 sites in United States, Australia and 2 more
- Volunteers
- 212 people
- Sponsor
- AbbVie
Renal Cell Carcinoma
Endoscopic Robot-Assisted Simple Enucleation Versus Standard Robot-Assisted Partial Nephrectomy in the Treatment of T1 Renal Cell Carcinoma
This is a non-inferiority, randomized controlled trial to compare the peri-operative, renal functional and oncologic outcomes of endoscopic robot-assisted simple enucleation(ERASE) and standard robot-assisted partial…
- Trial name
- NCT03624673
- Testing
- endoscopic robot-assisted simple enucleation, standard robot-assisted partial nephrectomy
- Where
- China
- Volunteers
- 380 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Major Depressive Disorder
Assessment of Transcultural Psychotherapy in Child Major Depressive Disorder
The symptomatic and clinical expression of psychiatric disorders in children and adolescents is strongly influenced by the cultural setting they are growing up in.
- Trial name
- EDPT-ADOS (NCT04206969)
- Testing
- Transcultural psychotherapy
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Patients Undergoing General Anesthesia
A Comparative Study of the Next-Generation TetraGraph® and Mechanomyography Neuromuscular Monitors in Clinical Settings
Background: Neuromuscular monitoring plays a critical role in reducing postoperative residual neuromuscular blockade (PRNB), a significant risk factor for respiratory complications.
- Trial name
- MMG vs EMG NG (NCT07750405)
- Testing
- Mechanomiograph (MMG), Electromiograph (EMG)
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Debrecen
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Monotherapy After PCI
Acetyl Salicylic Elimination Trial: The ASET Pilot Study
A multicenter, single arm, open-label trial of prasugrel monotherapy after PCI with the new-generation thin-strut biodegradable polymer everolimus-eluting SYNERGY® stent in patients with chronic stable angina
- Trial name
- ASET (NCT03469856)
- Testing
- Prasugrel monotherapy
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Pedro A. Lemos
Invasive Candidiasis
Comparison of Uncomplicated Candidemia Therapy Duration in Children and Adults
The goal of this clinical trial is to compare antifungal therapy duration in uncomplicated candidemia. The specific aims are: Compare the desirability of outcome ranking in patients with uncomplicated candidemia randomized to 7…
- Trial name
- COUNT (NCT05763251)
- Testing
- therapy duration
- Where
- 22 sites in United States, Australia
- Volunteers
- 420 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Post-stroke Depression, Post-stroke Aphasia
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
The present parallel-group, single-center, blinded-assessment controlled trial seeks to explore the feasibility - in terms of high completion rates - and potential efficacy of intensive communicative-pragmatic social interaction…
- Trial name
- CONNECT (NCT04318951)
- Testing
- Intensive communicative-pragmatic social interaction., Standard care.
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Medicine Greifswald
Massive Rotator Cuff Tears, Shoulder Disease
Effectiveness of Treatments for Massive Rotator Cuff Tears: Mixed Methodology.
The purpose of this study is: 1) to identify relevant treatment outcomes for people with massive rotator cuff tears of the shoulder joint, according to the experience of the affected people, to facilitate treatment shared…
- Trial name
- NCT05780229
- Testing
- Conservative treatment, Arthroscopic Decompression Surgery, Reverse Prosthesis
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Parc de Salut Mar
Charcot Foot Ulcer
Pulsed Electromagnetic Field Stimulation and Charcot Foot Ulcer
thirty-four patients with charcot foot ulcer will be included, their ages will be ranged from 50 to 70 years old and randomly distributed into two equal groups : study group includes 17 patients who will recieve pulsed…
- Trial name
- NCT06527131
- Testing
- pulsed electromagnetic field therapy, Transcutanous electrical nerve stimulation, Vancomycin
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Venous Stenosis, Venous Occlusion
The Merit WRAPSODY AV Access Efficacy Study (WAVE)
The purpose of the study is to demonstrate the safety and efficacy of the Merit WRAPSODY Endovascular Stent Graft for treatment of stenosis or occlusion within the dialysis access outflow circuit
- Trial name
- WAVE (NCT04540302)
- Testing
- Merit WRAPSODY Endovascular Stent Graft, PTA
- Where
- 43 sites in United States, Brazil and 2 more
- Volunteers
- 357 people
- Sponsor
- Merit Medical Systems, Inc.
Pancreatic Cancer
Celecoxib, Irinotecan and Concurrent Radiotherapy in Preoperative Pancreatic Cancer
The purposes of this study are to examine the effects of a new combination of drugs, celecoxib (Celebrex®) and irinotecan (CPT-11), with standard radiation therapy on people before they undergo surgery; to determine what effects…
- Trial name
- NCT00177853
- Testing
- celecoxib, irinotecan, concurrent radiotherapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
Bruxism
TMJ-1001 Bruxism Run-In/Pivotal Trial
The study is an open-label, prospective, multi-center, randomized, two treatment parallel, comparison study of the TMJ NextGeneration(TM) and custom-fit occlusal splint in the reduction of nocturnal bruxism episodes and monthly…
- Trial name
- NCT02269553
- Testing
- TMJ(TM) NextGeneration, Standard Hard TMJD Splint
- Sponsor
- TMJ Health
Scoliosis Idiopathic
Effect of Scoliosis-Specific Exercise on Lower Limb Biomechanics
PURPOSE: To examine the effect of Physiotherapeutic Scoliosis-Specific Exercise on limb biomechanical parameters in adolescents with idiopathic scoliosis.
- Trial name
- NCT06266637
- Testing
- Conventional Physical Therapy Program, Physiotherapeutic Scoliosis-Specific Exercise (Schroth)
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Delta University for Science and Technology
Pain, Anxiety
The Effect of Virtual Reality Use in Cystoscopy on Pain, Anxiety, and Comfort: A Randomized Controlled Trial
This study aims to evaluate the effects of virtual reality (VR) distraction on pain, anxiety, and comfort levels patients undergoing cystoscopy.
- Conditions
- Pain, Anxiety, Patient Comfort, Cystoscopy
- Trial name
- NCT07872137
- Testing
- Virtual Reality Distraction, Standard Care
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Karamanoğlu Mehmetbey University
Emergency Medicine
Development and Evaluation of a Patient Safety Model
Despite systems for early detection of critical illness, 12% of patients in the emergency department develop clinical deterioration with an increased risk of death as a result.
- Trial name
- NCT03457272
- Testing
- New risk assessment
- Where
- 4 sites in Denmark
- Volunteers
- 34,556 people
- Sponsor
- University of Aarhus
Glioblastoma
A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma
The objectives of this phase I first-in-human trial are to evaluate safety, feasibility, and preliminary efficacy of an individualized Bvax vaccine in addition to standard of care chemoradiation in patients with newly diagnosed…
- Trial name
- Bvax (NCT07422896)
- Testing
- B-cell vaccination
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Catalina Lee Chang
Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of alvespimycin hydrochloride in treating patients with metastatic or unresectable solid tumors.
- Conditions
- Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip, Recurrent Breast Cancer
- Trial name
- NCT00089362
- Testing
- alvespimycin hydrochloride, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Hepatitis C
Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3
This study will examine the effectiveness of low-dose peginterferon and ribavirin therapy for certain patients with chronic hepatitis C-a liver disease that, in some patients, can progress to cirrhosis of the liver, liver cancer…
- Trial name
- NCT00056862
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Spinal Cord Injuries
FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI
The main objective of this study is to determine the effectiveness of a new treatment regime that uses electrical stimulation for the improvement of hand function in persons with spinal cord injuries (SCI).
- Trial name
- NCT01208688
- Testing
- FES Therapy, Conventional Occupational Therapy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Toronto Rehabilitation Institute
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