Clinical trials: Standard treatment
CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic
Studies on Adsorption International Learning Initiative Global
Use of sorption technologies in patients undergoing maintenance hemodialysis with inflammatory syndrome and clinical manifestations of uremia
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic, Uremic; Toxemia, Inflammation Chronic
- Trial name
- SAILING (NCT07123909)
- Testing
- Patients will undergo a combined hemodialysis and hemosorption procedure. The study cartridge for hemosorption by Jafron HA130 contains the original adsorbing material.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Botkin Hospital
Severe Traumatic Brain Injury
Randomized Control Trial to Compare Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In 64 Severe Traumatic Brain Injury Patients, Aged 18 to 60 Years Old Undergoing Emergency Craniotomies
This randomized control trial aims to assess if Plethysmographic Variability Index (PVI)-based therapy improves patient outcome in terms of reduced amount and type of fluid used, lower postoperative lactate levels, lesser…
- Trial name
- PVI (NCT04664699)
- Testing
- Plethymographic Variability Index, Standard Monitoring
- Where
- Malaysia
- Volunteers
- 64 people
- Sponsor
- Universiti Sains Malaysia
Schizophrenia Spectrum and Other Psychotic Disorders, Mental Disorders, Severe
Family Psychoeducation for Adults With Psychotic Disorders in Tanzania
The goal of this study is to pilot test a culturally tailored Family Psychoeducation model (KUPAA) for adults with psychotic disorders and their relatives that is appropriate for cultural settings inclusive of both traditional…
- Trial name
- NCT04013932
- Testing
- KUPAA Intervention Group (Culturally Tailored Family Psychoeducation)
- Where
- 2 sites in Tanzania
- Volunteers
- 66 people
- Sponsor
- Duke University
Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury
Increased Adsorption Membranes During Cardiopulmonary Bypass
Our project intends to reduce cardiac surgery associated - acute kidney injury (CSA-AKI) in non emergent patients with the use of an increased adsorption membrane (oXiris®) connected to the cardiopulmonary bypass (CPB) circuit…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury, Systemic Inflammatory Response Syndrome, Acute Kidney Injury
- Trial name
- NCT02518087
- Testing
- oXiris®
- Where
- 3 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari de Bellvitge
Gynecologic Cancer, Prostate Cancer
CARE Tool Study Aim 3
This study is a multi-site randomized trial to study the implementation of the CARE Tool and evaluate the CARE Tool. The CARE Tool is a web-based tool that gives people information about cancer care costs, health insurance, and…
- Conditions
- Gynecologic Cancer, Prostate Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- NCT07296887
- Testing
- Financial education information, CARE Tool, CARE Tool Training
- Where
- 3 sites in United States
- Volunteers
- 430 people
- Sponsor
- Washington University School of Medicine
Cervical Carcinoma, Adenocarcinoma
PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer
This is an international, multicenter and randomized open-label phase III study designed to demonstrate, in patients with stage IIIC1 cervical cancer, whether para-aortic lymphadenectomy followed by tailored chemoradiation is…
- Conditions
- Cervical Carcinoma, Adenocarcinoma, Adenosquamous Carcinoma
- Trial name
- PAROLA (NCT05581121)
- Testing
- Standard treatment: Control arm, Experimental arm
- Where
- 37 sites in Czechia, France and 2 more
- Volunteers
- 510 people
- Sponsor
- Institut Claudius Regaud
Ventricular Arrhythmias, Persistent Atrial Fibrillation
Multimodal Image Processing Software to Guide Cardiac Ablation Therapy
MIGAT will develop and transfer software tools to assist ablation therapy of cardiac arrhythmias. The scientific background and objectives of MIGAT differ between atrial and ventricular arrhythmias, because the knowledge on…
- Trial name
- MIGAT (NCT02275104)
- Testing
- Contrast-enhanced ECG-gated multi-detector computed tomography, Magnetic resonance imaging, Positron emission tomography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Acute Heart Failure (AHF), Implementation Research
Implementation of Acute Heart Failure Checklist
Patients with acute heart failure (AHF) commonly present to the emergency department (ED) with difficulty breathing and often have poor outcomes or death.
- Trial name
- NCT07727304
- Testing
- CAEP Acute Heart Failure (AHF) Best Practices Checklist Implementation, Usual care
- Where
- Canada
- Volunteers
- 5,040 people
- Sponsor
- Ottawa Hospital Research Institute
Covid-19, Drug Effect
New Treatment for COVID-19 Using Ethanol Vapor Inhalation .
Since ARDS is a major complication of COVID - 19 with subsequent formation of non-cardiogenic pulmonary edema , worsening the oxygenation of the patients and foamy and even bloody sputum formation, so the idea is to use alcohol…
- Trial name
- NCT04554433
- Testing
- Ethanol with Asprin
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Heart Failure, Pulmonary Disease, Chronic Obstructive
Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD
Many Veterans living with heart failure or chronic obstructive pulmonary disease (COPD) experience significant symptoms - such as breathlessness, fatigue, depression, and anxiety -that reduce their quality of life.
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Interstitial Lung Disease
- Trial name
- VITALVET:ADAPT (NCT07714252)
- Testing
- Virtual Nurse and Social Worker Palliative Care Team, Enhanced Implementation Support, Standard Implementation Support
- Where
- 7 sites in United States
- Volunteers
- 420 people
- Sponsor
- VA Office of Research and Development
Blunt Trauma, Penetrating Wound
Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Primary Aim: To determine the feasibility and safety of hypotensive resuscitation for the early treatment of patients with traumatic shock compared to standard fluid resuscitation.
- Conditions
- Blunt Trauma, Penetrating Wound, Hemorrhagic Shock
- Trial name
- HypoResus (NCT01411852)
- Testing
- 0.9% Sodium Chloride 250 mL bolus, 0.9% Sodium Chloride 2000 mL bolus
- Where
- 6 sites in United States, Canada
- Volunteers
- 192 people
- Sponsor
- University of Washington
Brain Cancer, Brain Neoplasm, Primary
IDH1 Peptide Vaccine for Recurrent Grade II Glioma
Potential subjects with progressive Grade II primary brain tumor that have IDH1 positive testing from the primary tumor (initial diagnosis) will be offered this treatment study in order to test the safety of the PEPIDH1M vaccine…
- Conditions
- Brain Cancer, Brain Neoplasm, Primary, Brain Neoplasms, Recurrent, Brain Tumor
- Trial name
- RESIST (NCT02193347)
- Testing
- PEPIDH1M vaccine, Tetanus-Diphtheria Toxoid (Td), Temozolomide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Katy Peters, MD, PhD
Stroke
External Validation of Two Prediction Models for Independent Gait After Stroke
Regaining independent gait is one of the main goals in stroke rehabilitation and early prediction of gait outcome is important to guide discharge planning at acute stroke units, design rehabilitation and inform patients and…
- Trial name
- REPEAT (NCT05039047)
- Testing
- Standard stroke acute care and rehabilitation
- Where
- Switzerland
- Volunteers
- 149 people
- Sponsor
- Janne Veerbeek
Head and Neck Cancer
Navigation on Head and Neck Radiotherapy
The aim of this experimental study is to evaluate the effect of nurse navigation in the management of symptoms associated with head and neck radiotherapy.
- Trial name
- NCT04857749
- Testing
- Standard care, Navigation Nursing
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Selcuk University
Chronic Obstructive Pulmonary Disease, Hypercapnia
Non-invasive Home Ventilation in Patients With Severe Hypercapnic Chronic Obstructive Pulmonary Disease
In COPD patients with chronic hypercapnic respiratory failure, the prognosis is poor and the treatment with non invasive ventilation is actually well established. However the best mode of ventilation is not well known.
- Trial name
- SOMNOVENT' (NCT03934749)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Insomnia Chronic
Acceptance and Commitment Therapy as a New Treatment for Adults With Insomnia Disorder
Acceptance and Commitment Therapy plus sleep restriction (ACT) will be compared to Cognitive Behavioral Therapy for insomnia (CBT-I). CBT-I is the first line treatment for insomnia according to current guidelines.
- Trial name
- NCT04252638
- Testing
- Acceptance and Commitment Therapy plus Sleep Restriction, Cognitive Behavioral Therapy including Sleep Restriction
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Uncomplicated Urinary Tract Infection, Patient With Uncomplicated UTI
Effectiveness of Visual Storytelling Intervention on Antibiotic Adherence in UTI Patients
This study aims to evaluate the effectiveness of a visual storytelling intervention in improving antibiotic adherence among adults with urinary tract infections (UTIs).
- Trial name
- ABR UTI (NCT06885658)
- Testing
- Visual Storytelling Intervention for Antibiotic Adherence
- Where
- Pakistan
- Volunteers
- 358 people
- Sponsor
- Xi'an Jiaotong University
Major Depressive Disorder (MDD)
Magnesium Supplementation With Fluoxetine for Cognitive Function in Depression
The goal of this clinical trial is to evaluate whether magnesium supplementation can improve cognitive function in patients with depression receiving fluoxetine therapy.
- Trial name
- MAG-DEP (NCT07521358)
- Testing
- Fluoxetine (drug), Magnesium
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Hasanuddin University
Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction
CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction)
The clinical equipoise in the treatment of Atrial Fibrillation (AF) in patients with Heart Failure with mildly reduced Ejection Fraction/Heart Failure with Preserved Ejection Fraction (HFmrEF/HFpEF) reflects the scarcity of…
- Trial name
- NCT07254455
- Testing
- Catheter ablation
- Volunteers
- 900 people
- Sponsor
- Tulane University
Septic Shock
Protocolised Early De-Resuscitation in Septic Shock (REDUCE)
Background: Recent studies have questioned the safety of current fluid resuscitation strategies in patients with septic shock as prospective and observational data suggesting that the resulting fluid overload is associated with…
- Trial name
- REDUCE (NCT04931485)
- Testing
- Fluid management according to the REDUCE Fluid Protocol, Standard of care
- Where
- 4 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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