Clinical trials: Standard treatment
Non-Alcoholic Fatty Liver Disease
Ambulatory Liver Fat Monitoring in Patients With Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population and causes serious complications, including cirrhosis, hepatocellular carcinoma or mortality.
- Trial name
- NCT05754385
- Testing
- Ambulatory monitoring of liver fat, Standard of care
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The University of Hong Kong
Premature Birth, Obstetric Labor, Premature
Family Nurture Intervention in the NICU at The Valley Hospital
The purpose of this study is to compare neurodevelopment and activity in infants born preterm (25 to 34 1/7 weeks gestational age (GA)) receiving Standard Care (SC) or Family Nurture Intervention (FNI) in the neonatal intensive…
- Trial name
- NCT03267043
- Testing
- Family Nurture Intervention (FNI), Standard Care
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Venous Ulcers
Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
This study will test the safety and efficacy of nitric oxide gas in the treatment of venous leg ulcers
- Trial name
- NCT00545298
- Testing
- Nitric Oxide - same dose 6 wks, Nitric Oxide modified treatment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nitric BioTherapeutics, Inc
Non-Proliferative Diabetic Retinopathy
Intravitreal and Intracameral DEX in NPDR
To investigate the effects of intravitreal and intracameral injection of dexamethasone during cataract phacoemulsification in patients with mild to moderate non-proliferative diabetic retinopathy
- Trial name
- NCT06951087
- Testing
- Dexamethasone sodium phosphate
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Nantong University
Cardiac Valve Disease
Preoperative Optimization of Cardiac Valve Patients' Expectations
Recovery after surgery depends on psychological factors such as preoperative information, expectations and surgery-associated anxiety.
- Trial name
- ValvEx (NCT04502121)
- Testing
- EXPECT: Preoperative optimization of cardiac valve patient's expectations
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- Philipps University Marburg
Pancreatic Ductal Adenocarcinoma
Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer
This clinical trial investigates the nutrients pancreatic cancers depend on in which to survive and the processes these tumors use (metabolism) to obtain these nutrients.
- Trial name
- NCT05296421
- Testing
- Biopsy, Therapeutic Conventional Surgery, Uniformly-labeled [13C]glucose
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Rutgers, The State University of New Jersey
Lymphatic Filariases
Prevalence Studies After Triple Drug Therapy for Lymphatic Filariasis
This study will assess the impact of 2-drug (DA) or 3-drug (IDA) regimens on lymphatic filariasis infection parameters in communities.
- Trial name
- NCT03352206
- Testing
- 2 drug dose - DA, 3 drug dose - IDA
- Where
- 5 sites in Fiji, Haiti and 3 more
- Volunteers
- 20,092 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Return to Work, Musculoskeletal Disease
Contact to a Physician Specialized in Social Medicine and Return to Work
The aim of this study was to investigate the impact of a rehabilitation program including a physician specialized in social medicine parallel to treatment for suspected spinal disc herniation.
- Trial name
- NCT03010384
- Testing
- Rehabilitation program
- Volunteers
- 443 people
- Sponsor
- Kirsten Fonager
Covid19, COVID-19 Prevention
Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19
COVID-19 affected more than 9 million of people with more than 130 thousand death in India. If adequate preventive and therapeutic measures are not taken, India has very high risk of affecting million of more people with high…
- Trial name
- PEP-CQ (NCT04858633)
- Testing
- Hydroxychloroquine (HCQ), Standard care
- Where
- India
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Psychosocial Stress
Biobehavioral Effects of Therapy Dog Visitation in Elderly Intensive Care Unit Patients: A Pilot and Feasibility Study
The purpose of this study is to assess the preliminary efficacy of a 10-minute therapy dog visitation (TDV) in reducing biobehavioral stress responses.
- Trial name
- NCT02997852
- Testing
- Therapy dog visitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronavirus Disease 2019 )COVID-19)
Early transfusIon of Convalescent Plasma in Elderly COVID-19 Patients. to Prevent Disease Progression.
Older age is an independent poor outcome predictor among COVID-19 hospitalized patients . Among 72,314 COVID-19 cases, case fatality rate (CFR) was 2.3% in total population, 8% in people aged 70 to 79, and 14.8% in those aged 80…
- Trial name
- LIFESAVER (NCT04374526)
- Testing
- COVID-19 Convalescent Plasma
- Where
- 3 sites in Italy
- Volunteers
- 29 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypercapnia
Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea
The proposed study will measure the time from the end of surgery until the time patients meet the discharge criteria from the postoperative anesthesia care unit and the time from the end of surgery until the patients regained…
- Trial name
- NCT00708526
- Testing
- standard of care for phase one anesthesia care, Quick Emergence Device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Breast Cancer
Sentinel Lymph Node Biopsy With Superparamagnetic Iron Oxide for Breast Cancer Patients After Neoadjuvant Treatment.
The purpose of this study is to determine the detection rate and the false negative rate of sentinel lymph node (SLN) by superparamagnetic iron oxide (SPIO) alone or in addition to radioisotope and compared to the standard method…
- Trial name
- SENTINAC-01 (NCT02249208)
- Testing
- Tc+blue dye, Tc+SPIO, SPIO alone
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Recurrent Glioblastoma, Recurrent Gliosarcoma
Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma
This is a phase 0/1 dose-escalation trial to determine the maximum tolerated dose of Mycophenolate Mofetil (MMF) when administered with radiation, in patients with glioblastoma or gliosarcoma.
- Conditions
- Recurrent Glioblastoma, Recurrent Gliosarcoma, Recurrent Astrocytoma, Grade IV, Newly Diagnosed Glioblastoma
- Trial name
- NCT04477200
- Testing
- Mycophenolate Mofetil, Radiation Therapy, Re-resection (as part of standard of care)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Michigan Rogel Cancer Center
Malaria Falciparum
Private Medicine Retailer-based Trial of Malaria Tests and Conditional Treatment Subsidies Among Patients With Fever
The goal of this study observational study is to test the effect of conditional subsidies for Rapid Diagnostic Tests (RDT) and Artemisinin Combination Therapies (ACT) on improving the management of malaria fevers that seek care…
- Trial name
- NCT06928207
- Testing
- Provide the diagnostic (RDT) for free to clients suspected of having malaria and provide a subsidized ACT to only those testing positive
- Where
- Nigeria
- Volunteers
- 20 people
- Sponsor
- Clinton Health Access Initiative Inc.
Hepatitis C, Vasculitis
Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic Vasculitis
The purpose of this study is to assess the efficacy of Rituximab (anti-CD20) in the treatment of patients with hepatitis C associated cryoglobulinemic vasculitis (HCV-CV) who have failed or are intolerant to…
- Trial name
- NCT00029107
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma, Incentives
Financial Incentives to Reduce Pediatric Tobacco Smoke Exposures
Secondhand smoke exposure (SHSe) is one of the most common and potentially modifiable environmental triggers for asthma. Financial incentivization may serve as an effective modality to reduce SHSe among pediatric asthmatics with…
- Conditions
- Asthma, Incentives, Tobacco Smoking
- Trial name
- NCT03099811
- Testing
- Incentive plan, Smoking cessation
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cystic Fibrosis
Feasibility of a New Model for Exercise Prescription in Cystic Fibrosis
The purpose of this protocol is to begin an exercise program combined with behavioral counseling for patients who are hospitalized with a cystic fibrosis exacerbation. The exercise program will begin during the hospital stay.
- Trial name
- NCT04075864
- Testing
- Behavioral Counseling and Exercise
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Alabama at Birmingham
Hearing Loss, Speech and Language Development Delay Due to Hearing Loss
Teletherapy in Children Who Are Deaf and Hard of Hearing
This study seeks to determine the effectiveness of speech/language teletherapy to address disparities in speech and language outcomes in children who are deaf or hard-of-hearing (D/HH).
- Trial name
- NCT04928209
- Testing
- Speech-Language Teletherapy
- Where
- 5 sites in United States
- Volunteers
- 210 people
- Sponsor
- University of California, San Francisco
Multiple Myeloma
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of…
- Trial name
- iMMagine-3 (NCT06413498)
- Testing
- Anitocabtagene Autoleucel, Cyclophosphamide, Fludarabine
- Where
- 117 sites in United States, Australia and 13 more
- Volunteers
- 452 people
- Sponsor
- Kite, A Gilead Company
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