Clinical trials: Standard treatment
Septic Shock, Acute Adrenal Insufficiency
Adrenal Insufficiency in Septic Shock
Randomized controlled trial evaluating the duration of steroid replacement therapy in patients with adrenal insufficiency and septic shock.
- Trial name
- NCT00842933
- Testing
- Corticosteroid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- The Methodist Hospital Research Institute
Prader-Willi Syndrome
Cannabidiol Oral Solution for the Treatment of Patients With Prader-Willi Syndrome
The primary objective of this study is to assess the efficacy of cannabidiol oral solution on hyperphagia-related behavior in patients with Prader-Willi Syndrome (PWS).
- Trial name
- NCT02844933
- Testing
- Cannabidiol
- Where
- 7 sites in United States
- Volunteers
- 7 people
- Sponsor
- Radius Pharmaceuticals, Inc.
End-Stage Renal Disease
Intelligent Control Approach to Anemia Management
First clinical evaluation of "Smart Anemia Manager" algorithm.
- Trial name
- NCT00572533
- Testing
- ESA Dose Adjustment per standard Anemia Management Protocol, ESA Dose Adjustment per "Smart Anemia Manager" Algorithm
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Louisville
M-health, Metabolic Syndrome
Exercise-Targeted Smart Lifestyle Management
To investigate the effects of simple dietary management and diet combined with exercise capacity-targeted intelligent lifestyle management on improving metabolic indicators in patients with overweight/obesity and metabolic…
- Conditions
- M-health, Metabolic Syndrome, Lifestyle Alteration, Lifestyle (Sedentary Behavior and Physical Activity)
- Trial name
- NCT07535333
- Testing
- Dietary Prescription, Personalized Exercise Prescription, Metabolic Syndrome Prevention and Education
- Volunteers
- 435 people
- Sponsor
- China National Center for Cardiovascular Diseases
Autoimmune Diseases
Efficacy of Individualized Rituximab in Maintaining Remission of Moderate and Severe Systemic Lupus Erythematosus
Several clinical studies have shown that rituximab is safe and effective for the induction of remission in moderate to severe systemic lupus erythematosus, and has been recommended by several guidelines for the induction of…
- Trial name
- NCT04127747
- Testing
- Standard dose of rituximab, Individualized dose of rituximab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stage IV NSCLC
Safety and Tolerability Evaluation of Sintilimab in Combination With Radiation in Stage IV NSCLC Patients
This pilot phase I trial aims to investigate the safety and tolerability of anti-programmed cell death-1 (PD-1) monoclonal antibody Sintilimab (also called IBI308) in combination with concurrent stereotactic body radiation…
- Trial name
- NCT03812549
- Testing
- Sintilimab, stereotactic body radiation therapy, Low Dose Radiotherapy
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Sichuan University
Marijuana Dependence
Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management
Cognitive-behavioral coping skills therapy (CBT) is a widely used and recognized treatment that has been empirically validated for a range of substance use disorders, often with emergent effects and continuing improvement even…
- Trial name
- NCT00350649
- Testing
- Standard CBT, CBT+CM/adherence, CM/abstinence
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Yale University
Malnutrition, Child
Comparison of Different Feeding Protocols for the Treatment of Acute Malnutrition
Though malnutrition is prevalent worldwide but its situation is alarming in low- and middle-income countries. Pakistan has also been facing an alarming situation of prevailing severe malnutrition.
- Trial name
- NCT04045249
- Testing
- Home based food
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Integrated Reproductive Maternal Newborn & Child Health and Nutrition Program, Punjab
Peripheral Arterial Disease
Magnesium Oral Supplementation to Reduce Pain Inpatients With Severe Peripheral Arterial Occlusive Disease
Magnesium exerts analgesic effects in several animal pain models and in patients affected by acute postoperative pain and chronic pain of neuropathic origin.
- Trial name
- NCT02455726
- Testing
- Magnesium oxide, Fructose, Oxycodone
- Volunteers
- 150 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
HIV
The Treatment Ambassador Program: A Pilot Intervention to Increase Treatment Initiation
This study will evaluate the feasibility and acceptability of the Treatment Ambassador program - a peer-supported intervention targeting individuals living with HIV who have not started on treatment within at least 3 months of…
- Trial name
- NCT03099707
- Testing
- Treatment Ambassador
- Where
- South Africa
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hemorrhagic Fever, Ebola
Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in Guinea
This is an emergency, phase 2/3, open-label, non-randomized, clinical trial that will evaluate Convalescent Plasma (CP) added to standardized supportive care (SC) in patients with confirmed Ebola Virus Disease (EVD).
- Trial name
- Ebola-Tx (NCT02342171)
- Testing
- Convalescent Plasma
- Where
- Guinea
- Volunteers
- 606 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Torsades de Pointe Caused by Drug, Long QT Syndrome
Continuous Versus Intermittent cARdiac Electrical moNitorinG
The purpose of this study is to validate the continuous patch monitoring system to evaluate cardiac arrhythmias in patients receiving drugs that can cause cardiac complications and compare the continuous patch system with…
- Trial name
- CARING (NCT04336644)
- Testing
- BodyGuardian Mini Plus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Dental Caries in Children
Supportive Caries Preventive Programme in Children Undergoing Dental General Anaesthesia
Early childhood caries is a persistent problem often leading to dental treatment under general anaesthesia (GA). Thus, this study was to investigate the preventive effect of two additional intensive oral hygiene appointments…
- Trial name
- NCT05110534
- Testing
- additional oral hygiene appointments
- Where
- Germany
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Breastfeeding, Education, Nursing
Effect of a Newborn Simulator's Fidelity on Nursing Students' Level of Engagement in a Clinical Lactation Encounter
Nursing students (N=32) will be randomized to begin period 1 in either a high-fidelity or low-fidelity simulated experience with a mock patient wearing a breast model and holding a newborn simulator and then cross over in period…
- Trial name
- NCT05316909
- Testing
- Breastfeeding Simulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- LiquidGoldConcept
Diabetic Kidney Disease
Clinical Study on the Treatment of Diabetic Kidney Disease With Shenxiao Yuning Decoction With Syndrome of Qi and Yin Deficiency and Blood Stasis
To explore the therapeutic effect of Shenxiao Yuning Decoction on albuminuria and the improvement of traditional Chinese medicine syndrome in patients with stage III diabetic kidney disease with Qi and Yin deficiency and blood…
- Trial name
- SXYNT (NCT06176599)
- Testing
- Shenxiao Yuning decoction, Symptomatic treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Lin Liao
Meningeal Carcinomatosis
Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases
The purpose of this study is to determine whether the quantitative detection of circulating tumor cells (CTCs) in patients with Epcam expressing tumors can be used compared to standard qualitative method - cytology both in the…
- Trial name
- NCT01713699
- Testing
- lumbar puncture
- Where
- 2 sites in Netherlands
- Volunteers
- 146 people
- Sponsor
- The Netherlands Cancer Institute
Dental Pulp Necrosis, Apical Periodontitis
Antimicrobial Efficacy of NaOCl and PDT in Primary Root Canal Treatment
This clinical study will compare different root canal disinfection methods used during primary root canal treatment. Root canal infection is mainly caused by bacteria inside the root canal system.
- Trial name
- PDT-NaOCl (NCT07666932)
- Testing
- Sodium Hypochlorite Irrigation, Sodium Hypochlorite Irrigation Plus Photodynamic Therapy, Photodynamic Therapy Adjunct Evaluation
- Where
- Jordan
- Volunteers
- 64 people
- Sponsor
- Bayan Alqrenawi
Antithrombin III Deficiency, Covid19
Antithrombin III in Infectious Disease Caused by COVID-19
The purpose of this research study is to see if participants who have SARS-CoV-2 and low levels of AT3 in the blood will benefit by being given AT3.
- Trial name
- NCT04899232
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Enrique Ginzburg
Chronic Hepatitis C, Genotype 1
Pilot Study of Betaine + Combination Antiviral Therapy for Chronic Hepatitis C Genotype 1 Non-responder/Relapsers
This is a non-randomized, open-label study examining the safety and efficacy of betaine in addition to standard anti-viral therapy in genotype 1 hepatitis C non-responders or relapsers to previous pegylated interferon plus…
- Conditions
- Chronic Hepatitis C, Genotype 1, Relapse
- Trial name
- NCT00882193
- Testing
- Betaine, Peginterferon alpha 2a, Ribavirin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Nebraska
Endometrial Lesions
DWI MRI for Differentiating Endometrial Lesions in Comparison With Histopathology
The aim of this study is to evaluate the diagnostic accuracy of Diffusion Weighted Magnetic Resonance Imaging (DW MRI) in differentiating benign from malignant endometrial lesions, using histopathological examination as the…
- Trial name
- MRI in ELs (NCT07402421)
- Testing
- Diagnostic imaging (DWI MRI) in comparison with histopathology
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
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