Clinical trials: Thalidomide
Multiple Myeloma
Velcade,Thalidomide, and Dexamethasone Versus Velcade and Dexamethasone Versus Velcade, Melphalan, and Prednisone
This is a randomized, open label, multicenter clinical trial to compare the efficacy and safety of Velcade (bortezomib) and dexamethasone versus Velcade, thalidomide, and dexamethasone versus Velcade, melphalan, and prednisone in…
- Trial name
- UPFRONT (NCT00507416)
- Testing
- Bortezomib, Dexamethasone, Melphalan
- Where
- 235 sites in United States, Puerto Rico
- Volunteers
- 502 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Crohn's Disease
The Efficiency of MSC in Refractory Crohn's Disease
The investigators' preliminary study indicates that MSC is effective therapy in treating IBD. But the standard treatment is still lacking and the effect is not stable in IBD patients.
- Trial name
- NCT02532738
- Testing
- Routine Treatment of CD, MSC treatment 01, MSC treatment 02
- Volunteers
- 3 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Multiple Myeloma
MMVAR - Velcade: Study of Velcade for the Treatment of Myeloma Patients After Autologous Transplantation
This is an international study in adult patients diagnosed with multiple myeloma who have already received at least one autologous stem cell transplantation and who have responded but later progressed, or relapsed, at least one…
- Trial name
- NCT00256776
- Testing
- Velcade (Bortezomib), Thalidomide, Dexamethasone
- Where
- 81 sites in Austria, Belgium and 8 more
- Volunteers
- 269 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Immune Thrombocytopenia
High-dose Dexamethasone Combining Thalidomide Versus Dexamethasone Mono-therapy for Management of Newly-diagnosed ITP
The project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of thalidomide combining with high-dose dexamethasone for the treatment of adults with primary immune…
- Trial name
- NCT01976195
- Testing
- Dexamethasone, Thalidomide
- Where
- China
- Sponsor
- Shandong University
Relapse and / or Refractory Myeloma
Daratumumab, Thalidomide and Dexamethasone in Relapse and/or Refractory Myeloma
Myeloma patients who relapse after prior treatment with bortezomib and lenalidomide have survival of less than 1 year. A number of new drugs have been approved for the treatment of relapse myeloma in the last couple of years…
- Trial name
- NCT03143036
- Testing
- Daratumumab, thalidomide and dexamethasone
- Where
- 5 sites in Hong Kong, Singapore and 2 more
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Prostatic Neoplasms
Docetaxel, Thalidomide, Prednisone, and Bevacizumab to Treat Metastatic Prostate Cancer
This is a Phase II study of docetaxel, bevacizumab, prednisone and thalidomide in patients with androgen independent metastatic prostate cancer who are previously untreated with chemotherapy.
- Trial name
- NCT00089609
- Testing
- Docetaxel, Thalidomide, Prednisone
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- National Cancer Institute (NCI)
Cancer, Therapy-Related
The Evaluation of Curative Effect on Treatment of Tumor Above Thalidomide Combined With Megestrol
To observe the effect of thalidomide combined with megestrol acetate on lymphocyte, inflammatory factor regulation and nutritional status in patients with advanced malignant tumors.
- Trial name
- NCT03777930
- Testing
- Chemotherapy drugs, thalidomide and megestrol acetate, optimal support treatment
- Volunteers
- 200 people
- Sponsor
- Shenzhen Fifth People's Hospital
Hepatocellular Carcinoma
Transarterial Chemotherapy Compared With Oral Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma
In India, majority of our patients have advanced hepatocellular carcinoma (HCC) at presentation and hence are unsuitable for the available curative treatment options. In such patients the treatment options are mainly palliative.
- Trial name
- NCT02240771
- Testing
- Transarterial chemotherapy, Oral chemotherapy
- Where
- India
- Volunteers
- 124 people
- Sponsor
- All India Institute of Medical Sciences
Lung Cancer
Thalidomide in Treating Patients With Extensive-Stage Small Cell Lung Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: Phase II trial to study the effectiveness of thalidomide in treating patients who have extensive-stage small cell lung cancer that…
- Trial name
- NCT00053300
- Testing
- thalidomide, adjuvant therapy
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Bone Marrow Transplantation, Blood Disease
Blood and Marrow Transplant Clinical Research Network
The purpose of this network is to accelerate research in hematopoietic stem cell transplantation by comparing novel therapies to existing ones.
- Conditions
- Bone Marrow Transplantation, Blood Disease, Hematopoietic Stem Cell Transplantation, Leukemia
- Trial name
- NCT00023530
- Testing
- fluconazole, voriconazole, bone marrow transplant
- Where
- 16 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Multiple Myeloma
Phase II Study of Thalidomide, Clarithromycin, Lenalidomide, and Dexamethasone for Newly Diagnosed Multiple Myeloma
Study Objectives 1. Evaluate the efficacy of the combination of thalidomide (Thalomid®), clarithromycin (Biaxin®), lenalidomide (Revlimid®), and dexamethasone (Decadron®) as an induction therapy for patients with newly diagnosed…
- Trial name
- T-BiRD (NCT00538733)
- Testing
- thalomid, lenalidomide, clarithromycin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Weill Medical College of Cornell University
Multiple Myeloma, Plasma Cell Myeloma
S0833, Bortezomib, Thalidomide, Lenalidomide, Combination Chemotherapy, and Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as thalidomide and lenalidomide, may stimulate the immune system in different ways and…
- Trial name
- NCT01055301
- Testing
- bortezomib, cisplatin, cyclophosphamide
- Where
- 21 sites in United States
- Sponsor
- SWOG Cancer Research Network
Amyloidosis
Efficacy of CC-5013 (Revlimid or Lenalidomide) in Patients With Primary Systemic Amyloidosis
Patients with primary systemic amyloidosis will be treated with CC-5013 (lenalidomide; Revlimid) as a single agent for 3 months.
- Trial name
- NCT00166413
- Testing
- CC-5013
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Oral Mucositis, Quality of Life
Thalidomide With or Without Probiotics in Radioactive Oral Mucositis
Study on the application of thalidomide with or without probiotics in radioactive oral mucositis
- Trial name
- NCT05059613
- Testing
- probiotics
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jiangxi Provincial Cancer Hospital
Peritoneal Dialysis, Malnutrition
Thalidomide for the Treatment of Malnutrition Inflammation Syndrome in Peritoneal Dialysis Patients
Hypothesis In peritoneal dialysis (PD) patients, malnutrition, inflammation and atherosclerotic cardiovascular disease commonly coexist. The triad has been coined the "MIA syndrome".
- Trial name
- NCT00390247
- Testing
- thalidomide
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Hepatocellular Carcinoma
Study of Sorafenib With Combination of Thalidomide in Hepatocellular Carcinoma (HCC)
The purpose of this phase I study is to determine the maximal tolerable dose (MTD) of thalidomide (THADO®) in combination with fixed dose of sorafenib (NEXAVAR®) for the treatment of advanced or metastatic HCC.
- Trial name
- NCT00971126
- Testing
- sorafenib (Nexavar®), thalidomide (Thado®)
- Where
- Taiwan
- Volunteers
- 3 people
- Sponsor
- National Health Research Institutes, Taiwan
Coronary Artery Disease
Thalidomide fOr the Prevention of Restenosis After Coronary ArtERy Stent Implantation
Percutaneous coronary intervention (PCI) with the use of bare metal stents is associated with restenosis in approximately 10% to 50% of cases.
- Trial name
- TOP RACER (NCT01638078)
- Testing
- Thalidomide
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Liver Cirrhosis, Gastric Antral Vascular Ectasia
Thalidomide Versus Argon Plasma Coagulation in Gastric Antral Vascular Ectasia(GAVE)-Related Anaemia in Cirrhosis (TAG Trial)
Gastric Antral Vascular Ectasia (GAVE) is an erosive form of gastritis distinguished by veno-capillary ectasia, which manifests as tortuous columns of dilated vessels.
- Trial name
- NCT06772480
- Testing
- Thalidomide, Argon Plasma Coagulation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Multiple Myeloma
Velcade, Melphalan, Prednisone And Thalidomide Versus Velcade, Melphalan, Prednisone in Multiple Myeloma Patients
The proposed study will evaluate whether the combination of VELCADE, Thalidomide , Melphalan and Prednisone (V-MPT), as induction treatment for newly diagnosed elderly MM patients, improves outcomes compared to the combination…
- Trial name
- NCT01063179
- Testing
- Bortezomib, Melphalan, Prednisone, Thalidomide, Bortezomib, Melphalan, Prednisone
- Where
- Italy
- Volunteers
- 511 people
- Sponsor
- Fondazione EMN Italy Onlus
Brain Stem Neoplasms, Primary, Neoplasms, Brain Stem
Thalomid and Carboplatin for the Treatment of Pediatric Brain Stem Glioma
Treatment on this study combines two drugs: Thalomid™ (thalidomide) and carboplatin. Thalidomide has been available for many years and has been used to treat many different illnesses.
- Trial name
- NCT00179881
- Testing
- Carboplatin, Thalomid, External Beam Radiation Therapy
- Where
- 6 sites in United States
- Volunteers
- 47 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago