Clinical trials: Treatment as usual
Depression, Opioid Use
Opioid Treatment and Recovery Through a Safe Pain Management Program
Opioid prescription drug abuse has become a major public health concern in the United States with mortality rates from fatal overdoses reaching epidemic proportions.
- Conditions
- Depression, Opioid Use, Chronic Pain, Anxiety
- Trial name
- NCT03889418
- Testing
- Electronic medical recorded clinical decision support [EMR CDS], Stepped opioid collaborative care model [CCM]
- Where
- United States
- Volunteers
- 490 people
- Sponsor
- Ochsner Health System
Diabetes
Appropriation of the Connected Solution Freestyle Libre® in Adult Patients With Diabetes in the Context of Therapeutic Education
Following the proposal to self-monitor by the Freestyle Libre® (FSL) connected object, in diabetic patients in the context of therapeutic education, regarding the appropriation of FSL, what works, for which patients , in what…
- Trial name
- APPRO-FSL (NCT04739124)
- Testing
- Follow-up questionnaires, Interviews
- Where
- 2 sites in France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Mild Cognitive Impairment (MCI)
Evaluation of the Effect of Healthy Lifestyle Intervention for Patients With Mild Cognitive Impairment
This clinical study aims to evaluate the feasibility and preliminary effectiveness of a comprehensive lifestyle intervention program for patients with mild cognitive impairment.
- Trial name
- NCT06942780
- Testing
- Exercise intervention, Social intervention, Dietary intervention
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Gulf War Illness, Insomnia
Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Sleep disturbance is a common complaint of Veterans with Gulf War Illness (GWI). Because there is clinical evidence that sleep quality influences pain, fatigue, mood, cognition, and daily functioning, this study will investigate…
- Trial name
- CBTi GWI (NCT02782780)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTi)
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
Study of 18 mg Selincro® As-needed Use, in the Treatment of Patients With Alcohol Dependence in Primary Care
To determine the reduction in alcohol consumption in patients with alcohol dependence treated with 18 mg Selincro® as-needed use, in conjunction with continuous psychosocial support in primary care
- Trial name
- NCT02195817
- Testing
- Selincro® 18 mg with continuous psychosocial support: Cohort A, Initial psychosocial support: Cohort B
- Where
- 48 sites in France, Germany and 2 more
- Volunteers
- 378 people
- Sponsor
- H. Lundbeck A/S
Low Back Pain, Anxiety
Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration
Since the Covid-19 crisis, patients appear more stressed, with increasing fear of exams and the hospital environment, in particular for CT scan teams, which require injections.
- Trial name
- MKI-TDM (NCT06928740)
- Testing
- Music Care® device, EMONO
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pancreatitis
Phosphate in Acute Pancreatitis
The goal of this study is to learn if phosphate administration works to treat acute pancreatitis in adults presenting to the emergency department at Duke University Hospital.
- Trial name
- PPP (NCT07681050)
- Testing
- Sodium Phosphate, Potassium Phosphate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
ALS, Charcot Disease
Satisfaction of Patients With Amyotrophic Lateral Sclerosis Regarding Home Assisted Teleconsultation
Satisfaction of patients with amyotrophic lateral sclerosis under non-invasive ventilation regarding home assisted teleconsultation
- Trial name
- VNI_SLA (NCT05621213)
- Testing
- Teleconsultation assisted by a physiotherapist or nurse
- Where
- 2 sites in France
- Volunteers
- 38 people
- Sponsor
- AGIR à Dom
Alzheimer Dementia, Agitation,Psychomotor
Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)
This study will explore the effect of ECT treatments plus usual care (ECT+UC) in reducing severe agitation in patients with moderate to severe dementia including Alzheimer's Disease, Vascular dementia, Frontotemporal dementia…
- Trial name
- ECT-AD (NCT03926520)
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Brent Forester
Alcohol Use Disorder
Black Church Treatment Study
This study will conduct a randomized clinical trial comparing levels of treatment initiation, engagement, and alcohol outcomes for a novel treatment strategy (CBT4CBT delivered in the Black church) compared with traditional…
- Trial name
- NCT04580810
- Testing
- CBT4CBT in the Black Church
- Where
- 3 sites in United States
- Volunteers
- 137 people
- Sponsor
- NYU Langone Health
Hypertrophic Cardiomyopathy
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with…
- Trial name
- SILICOFCM (NCT03832660)
- Testing
- Lifestyle, Sacubitril/Valsartan
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 168 people
- Sponsor
- Newcastle University
Vulvodynia, Chronic Pain
Multidisciplinary Treatment of Chronic Vulvar Pain
Vulvodynia (i.e. chronic vulvar pain without identifiable cause) is a heterogeneous clinical entity with a complex multifactorial causation.
- Trial name
- NCT03640624
- Testing
- Multidisciplinary treatment, Treatment as usual
- Where
- Norway
- Volunteers
- 106 people
- Sponsor
- Norwegian University of Science and Technology
Opioid Use Disorder
The ConCERN Intervention for Loved Ones of Those With Opioid Use Disorder
Evidence suggests that friends and family play an important role in supporting loved ones that are addicted to opioids. However, there are limited unique resources available for this population of friends and family.
- Trial name
- ConCERN (NCT07795840)
- Testing
- ConCERN intervention, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 700 people
- Sponsor
- University of Michigan
Suicidal Ideation, Suicide Attempt
Real-time Intervention for Suicide Risk Reduction
The aim of this study is to determine whether learning three skills for managing negative emotions and receiving reminders via smartphone to practice these skills reduces how often and how intensely one experiences emotional…
- Trial name
- NCT05848089
- Testing
- Brief skills sessions plus EMI skills practice prompts, Ecological momentary assessment (EMA), Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder, Borderline Personality Disorder
Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder and Borderline Personality Disorder (PTSD-BPD)
Posttraumatic Stress Disorder (PTSD) with co-occurring Borderline Personality Disorder (BPD) (i.e., PTSD-BPD) is common (as high as 58%), debilitating, costly, and limited treatment options available for this population.
- Trial name
- NCT04230668
- Testing
- Cognitive Processing Therapy with Suicide Risk Management, Treatment as Usual with Suicide Rick Management
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Palo Alto University
Gonorrhea, Neisseria Gonorrhoeae
Washington State Community Expedited Partner Treatment (EPT) Trial
The Washington State Community Expedited Partner Therapy Trial is a stepped-wedge community level randomized trial designed to test the hypothesis that a public health program designed to increase the use of expedited partner…
- Conditions
- Gonorrhea, Neisseria Gonorrhoeae, Chlamydia Trachomatis
- Trial name
- NCT01665690
- Testing
- Patient delivered partner therapy, Targeted public health partner services
- Where
- 2 sites in United States
- Volunteers
- 33,222 people
- Sponsor
- University of Washington
Bariatric Surgery Candidate, Obesity, Morbid
Prophylactic Use of Noninvasive Ventilation in the Postoperative Period of Bariatric Surgery
Comorbidities associated with severe obesity determine an important public health problem. Few methods are considered potentially effective for the treatment of severe obesity and the clinical relevance of bariatric surgery is…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Ventilatory Failure
- Trial name
- NCT04805476
- Testing
- Non invasive mechanical ventilation, GP
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Major Depressive Disorder
Impact of Psychomotor Therapy on the Quality of Life in Depression
The effectiveness of psychomotor therapy in improving clinical outcomes or quality of life for individuals with depression is unclear.
- Trial name
- PsyMot-Dep (NCT06234176)
- Testing
- Personalised psychomotor therapy, Usual treatment
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Esquirol
Community-acquired Pneumonia
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and…
- Trial name
- PRONECAP (NCT06966310)
- Testing
- Prone position
- Where
- 38 sites in France
- Volunteers
- 1,078 people
- Sponsor
- University Hospital, Tours
Diet Modification
Therapeutic Nutrition With Technology in Primary Care
Low-carbohydrate diets (less than approximately 130 grams per day) are emerging as an efficacious treatment option with several studies supporting weight loss and remission of type 2 diabetes.
- Trial name
- NCT04616482
- Testing
- Digital therapeutic carbohydrate restriction (TCR) program
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
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