Clinical trials: Treatment as usual
Multiple Sclerosis (MS) - Relapsing-remitting
The Effect of Metformin As an Adjuvant Therapy on Immunological Parameters in Egyptian Patients with RRMS: a Pilot Study
This pilot study aims to investigate the tolerability and feasibility of using metformin as an adjuvant treatment for RRMS. Also, it aims to evaluate the preliminary evidence of its efficacy by analyzing outcomes related to…
- Trial name
- NCT06812585
- Testing
- Metformin (Cidophage®), Usual Care
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- German University in Cairo
Colorectal Cancer With Liver Metastases
ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer ( MetaIRM)
Currently, the tumor response of operated colorectal liver metastases is assessed by histology of the resection specimen.The histological data make it possible to define categories (responder, partial responder, non-responder).
- Trial name
- MetaIRM (NCT06552117)
- Testing
- an elastoMRI sequence
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Low Back Pain, Pain, Postoperative
Electroacupuncture as a Complement to Usual Care for Patients With Non-acute Pain After Back Surgery
The purpose of this study is to find out the effectiveness of integrative medicine model for pain relief and improvement of function and quality of life on the patients with pain after back surgery.
- Conditions
- Low Back Pain, Pain, Postoperative, Failed Back Surgery Syndrome
- Trial name
- NCT01966250
- Testing
- electroacupuncture and usual care, Usual care
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Korean Medicine Hospital of Pusan National University
Colorectal Surgery
The Protocol of Enhanced Recovery After Surgery in Colorectal Surgery
The purpose of this study is to determine whether ERAS is safe and can decrease surgical stress, increase functional recovery and reduce complication rate in colorectal surgery.
- Trial name
- ERAS (NCT00498290)
- Testing
- enhanced recovery after surgery (ERAS) protocol, control
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fudan University
Musculoskeletal Diseases or Conditions, Emergency Department
Advanced Practice Physiotherapy Care in Emergency Departments
Overcrowding in emergency departments (ED) is a major concern worldwide. Recent reports show that Canada has among the longest ED waiting times and limited access to care has been associated with poorer outcomes for many…
- Conditions
- Musculoskeletal Diseases or Conditions, Emergency Department, Physiotherapy
- Trial name
- NCT05545917
- Testing
- Experimental: APP care, Control - Usual physician care
- Volunteers
- 744 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Sleep Quality
Identifying At-Risk Patients and Predicting Deterioration of In-Patients Using Continuous Heart Rate, Respiratory Rate, and Movement Monitoring
Currently, all patients in the hospital are woken up throughout the night to check for vital signs, no matter how sick they are.
- Trial name
- NCT03010774
- Testing
- Risk Stratification, Usual Care
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Chicago
Substance Use Disorders, Criminal Behavior
Improving Outcomes in Social Services Through Routine Outcome Monitoring and Systematic Client Feedback
In this project the investigators want to test whether a new method FIT (Feedback informed treatment) can improve the interventions people receive through social services.
- Conditions
- Substance Use Disorders, Criminal Behavior, Domestic Violence, Social Care
- Trial name
- NCT07303608
- Testing
- Feedback informed treatment (FIT), Treatment as usual (TAU)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Chronic Kidney Diseases, Kidney Failure, Chronic
Decision Aid for Renal Therapy
Good communication among patients, their families and loved ones, and their medical care providers is important when figuring out how to treat chronic diseases like kidney disease.
- Trial name
- DART (NCT03522740)
- Testing
- Decision Aid for Renal Therapy
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Tufts University
Posttraumatic Stress Disorder
A Randomized Controlled Trial of Metacognitive Therapy and EMDR for Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a frequently occurring and often debilitating anxiety disorder resulting from exposure to trauma.
- Trial name
- NCT01955590
- Testing
- Metacognitive therapy, EMDR, Treatment as usual
- Where
- Norway
- Volunteers
- 96 people
- Sponsor
- Norwegian University of Science and Technology
Diffuse Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas
This phase II/III trial tests whether it is possible to decrease the chance of high-grade B-cell lymphomas returning or getting worse by adding a new drug, venetoclax to the usual combination of drugs used for treatment.
- Conditions
- Diffuse Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Double-Expressor Lymphoma, EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT03984448
- Testing
- Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography
- Where
- 634 sites in United States
- Volunteers
- 363 people
- Sponsor
- National Cancer Institute (NCI)
Major Depressive Disorder, PTSD
McLean and Genomind Prospective Study
This is a three month naturalistic prospective, randomized, open label study of pharmacogenetic testing and clinical outcomes in inpatients across diagnoses, including Treatment Resistant Depression (TRD) with or without…
- Trial name
- GPS (NCT03113890)
- Testing
- Phlebotomy - Folate, Cheek Swab, Self-report surveys
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mclean Hospital
Neck Pain
Benefit of Adding Stretching to Standard Intervention For Patients With Nonspecific Mechanical Neck Pain
The purpose of this study is to assess the benefit of adding stretching exercises to cervical mobilization and cervical range of motion exercises on cervical range of motion, pain, pain threshold, level of disability and patient…
- Trial name
- NCT03194490
- Testing
- combined intervention group, The standard intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Stress Disorders, Post-Traumatic
Safety and Efficacy of Cognitive Behavior Therapy for People With Post-traumatic Stress and Cardiovascular Illness
This study will evaluate the safety and efficacy of cognitive behavioral therapy in treating people who are experiencing post-traumatic stress disorder after a heart attack.
- Trial name
- NCT00364910
- Testing
- Cognitive behavioral therapy (CBT), Educational session and treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Disease, Serious Mental Illness
Improving Health and Wellness for People With Serious Mental Illness in Puerto Rico
This study evaluates the effectiveness of a culturally tailored intervention, Bridges to Better Health and Wellness (BRIDGES), aimed at reducing chronic disease disparities among Puerto Ricans with serious mental illness (SMI).
- Trial name
- BRIDGES (NCT06859060)
- Testing
- BRIDGES Healthcare Manager Intervention, Enhanced Treatment as Usual (ETAU)
- Where
- 2 sites in Puerto Rico
- Volunteers
- 300 people
- Sponsor
- Ponce Medical School Foundation, Inc.
ICP1, Depression
Integrated Care Pathway for Youth Depression
Major Depressive Disorder in adolescence is prevalent and debilitating. Our group aims to improve treatment response through the use of an Integrated Care Pathway (ICP) based on a high quality Clinical Practice Guideline and…
- Conditions
- ICP1, Depression, Adolescent Behavior
- Trial name
- CARIBOU (NCT03428555)
- Testing
- Integrated Care Pathway, Treatment As Usual
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Stroke
F@ce 2.0 - Information and Communication Technology-based Rehabilitation Intervention After Stroke in Sweden
The purpose of the present proposal is to implement and evaluate a new model for mobile phone supported and family-centred rehabilitation intervention (F@ce 2.0) with regard to functioning in activities in daily living and…
- Trial name
- NCT04351178
- Testing
- Mobile phone supported and team based rehabilitation, Rehabilitation as usual
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Opioid Use Disorder
Sex and Female Empowerment
This study will develop and initially evaluate Sex and Female Empowerment (SAFE), an intervention designed to increase acceptance of and adherence to contraceptive practices among opioid-agonist-maintained women of childbearing…
- Trial name
- SAFE (NCT02197715)
- Testing
- Computer-adaptive SAFE, Face-to-face SAFE, Usual Care
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Borderline Personality Disorder
BOSCOT : A Randomised Controlled Trial of Cognitive Behavioural Therapy in Borderline Personality Disorder
The aim of the study was to investigate if the addition of cognitive behavioural therapy to treatment as usual (CBT plus TAU) in participants with borderline personality disorder would decrease the number of participants with…
- Trial name
- BOSCOT (NCT00538135)
- Testing
- Cognitive Behavioural Therapy, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Aberdeen
Cardiac Arrest, Post-cardiac Arrest Care
Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and…
- Trial name
- LAPTOPS (NCT06992843)
- Testing
- Goal-directed care bundle for neuroprotection, Usual Care
- Where
- China
- Volunteers
- 1,008 people
- Sponsor
- Xiangya Hospital of Central South University
Patients at Ultra-high Risk of Psychosis
Effects of Neurocognitive and Social Cognitive Remediation in Patients at Ultra-High Risk of Psychosis
Cognitive deficits are known to be a core feature of schizophrenia and seem to become manifest in the prodromal or Ultra-High Risk (UHR) state of psychosis.
- Trial name
- FOCUS (NCT02098408)
- Testing
- Cognitive remediation, Standard treatment
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
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