Clinical trials: Treatment as usual
Parkinson Disease
Robotic Walking Device to Improve Mobility in Parkinson's Disease
This Phase II randomized controlled trial proposes to examine the impact of long-term use of a novel light-weight and wearable assistive robotic device, called the Honda Walking Assist (HWA) device, to improve mobility in the…
- Trial name
- NCT03751371
- Testing
- Training with HWA device, Usual Care
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ohio State University
Primary Malignant Brain Tumors
SmartCare: Innovations in Caregiving Interventions
This is a study to evaluate the effectiveness of using an established intervention for depressive symptom management in conjunction with a needs-based caregiver intervention for improving the psychological and physical health of…
- Trial name
- SmartCare (NCT02058745)
- Testing
- CAU+ (Enhanced Care as Usual), Beating the Blues, SmartCare
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus Type II, Hypertension
Scaling Telehealth Models to Improve Co-morbid Diabetes and Hypertension (Phase II)
The purpose of this study is to test the effectiveness and implementation process of a culturally and contextually tailored telehealth-based community health worker (CHW) led coaching intervention for hypertension control among…
- Trial name
- NCT06542939
- Testing
- Integrated CHW Intervention, CHW Session 1 Only
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Chronic Kidney Disease
Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human
The key objective of this pilot study is to assess the molecular mechanisms of renal pre-conditioning by a one-week low-calorie diet in humans.
- Trial name
- CR_LSP (NCT02745444)
- Testing
- low-calorie formula diet, protein-restricted diet
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Cerebral Palsy
Working Memory Training for Children With Cerebral Palsy
Cerebral palsy (CP) is the most common motor disability in childhood (2-3 per 1000 live born), and is frequently accompanied by cognitive impairments and behavioural problems.
- Trial name
- NCT02119364
- Testing
- Working memory training
- Where
- Norway
- Volunteers
- 115 people
- Sponsor
- Sorlandet Hospital HF
Child Mental Disorder, Anxiety Disorders
Youth Metacognitive Therapy Feasibility Trial
One in eight children and young people (CYP) suffer mental health problems needing support or treatment and 5% have more than one such problem.
- Conditions
- Child Mental Disorder, Anxiety Disorders, Depression
- Trial name
- YoMETA (NCT05260060)
- Testing
- Treatment as usual: Control, Group Metacognitive Therapy (Group-MCT): Experimental
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Manchester
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Suicidal Ideation, Suicide
Randomized Clinical Trial of Supplementing Brief Psychotherapy With a Mobile App
The aim of this study is to determine whether learning three skills for managing negative emotions and receiving reminders via smartphone to practice these skills reduces how often and how intensely one experiences emotional…
- Conditions
- Suicidal Ideation, Suicide, Suicide Attempt
- Trial name
- NCT06555094
- Testing
- Ecological momentary assessment (EMA), Treatment as usual (TAU), Brief skills sessions plus EMI skills practice prompts
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy
Acupuncture for Symptoms of Nerve Damage
The purpose of this study is to compare the effects of real acupuncture with placebo acupuncture or usual care on symptoms of nerve damage from chemotherapy.
- Trial name
- NCT03183037
- Testing
- Acupuncture, Usual Care Group, questionnaires
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Atrial Fibrillation, Thrombus Due to Heart Valve Prosthesis
The Effect of Medication Timing on Anticoagulation Stability in Users of Warfarin: The "INRange" RCT
Warfarin is an anticoagulant medication that is highly effective at preventing clotting disorders but which has a narrow therapeutic window.
- Conditions
- Atrial Fibrillation, Thrombus Due to Heart Valve Prosthesis, Deep Venous Thrombosis, Thromboembolism
- Trial name
- NCT02376803
- Testing
- Warfarin
- Where
- 2 sites in Canada
- Volunteers
- 217 people
- Sponsor
- University of Alberta
Cardiac Valve Disease, Coronary Artery Disease
Telehealth Interventions for Cardiac Surgery
The goal of this clinical trial is to compare telehealth monitoring at home against usual care in patients undergoing planned heart surgery. The main questions it aims to answer are: 1.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Surgical Complication
- Trial name
- TICS (NCT05621954)
- Testing
- Telehealth Monitoring
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Eating Disorders, Anxiety
Non-invasive Cranial Electrical Stimulation for Mealtime Anxiety in Adults With Eating Disorders
The study is to evaluate the feasibility of using a non-invasive brain stimulation device in a sample of inpatients with eating disorders (ED).
- Trial name
- NCT07017322
- Testing
- Alpha-Stim AID
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rogers Behavioral Health
Obstructive Sleep Apnea
Peer-Driven Intervention for Sleep Apnea
Fragmentation of care can lead to poor treatment adherence in patients with chronic medical conditions which can, in turn, lead to adverse health consequences, poor quality of life, and patient dissatisfaction.
- Trial name
- PCORI (NCT02056002)
- Testing
- Usual Care, Peer-Buddy System
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of Arizona
Autism Spectrum Disorder
Multisensory Room in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex neurological development with onset in infancy or early childhood. Atypical sensory processing has been widely reported in ASD, and recent literature suggest that this abnormality…
- Trial name
- NCT06184802
- Testing
- TAU+Multisensory room, TAU
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Sickle Cell Disease
Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCD
This registry is an observational study designed to evaluate the effect of Oxbryta in individuals with SCD in a real-world setting.
- Trial name
- PROSPECT (NCT04930445)
- Testing
- Oxbryta® (voxelotor) 500mg Tablets
- Where
- 43 sites in United States
- Volunteers
- 265 people
- Sponsor
- Pfizer
Bulimia Nervosa, Eating Disorder
Rapid Response to Day Hospital Treatment in Bulimia Nervosa and Purging Disorder
Treatments for bulimia nervosa (BN) have relatively high rates of nonremission and relapse, meaning that improving treatments is a high priority in this area.
- Trial name
- CBT-RR (NCT02444065)
- Testing
- Cognitive Behavior Therapy (CBT), Motivational Interviewing (MI)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Postpartum Depression (PPD), Alcohol Use
Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms
This study aims to learn about depression and alcohol use in postpartum mothers and whether an intervention based on contingency management and problem-solving therapy (CM-PST) can help reduce these symptoms.
- Conditions
- Postpartum Depression (PPD), Alcohol Use, Contingency Management, Problem Solving Therapy
- Trial name
- MOMS-AD (NCT07485036)
- Testing
- Contingency Management & Problem Solving Therapy, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Myocardial Infarction
Study on the Efficacy and Mechanism of Cardiac Rehabilitation for Stem Cell Mobilization and Heart Failure Improvement
One emerging concept is that some form of injury or inflammation is a prerequisite for the success of circulating-cell participation in differentiated tissue structure and function.
- Trial name
- NCT00154466
- Testing
- cardiac rehabilitation
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- National Taiwan University Hospital
Post-Traumatic Stress Disorder
Implementation of an Evidence Based Post-Traumatic Stress Disorder (PTSD) Treatment in Public Sector Settings
Researchers hope to learn whether a flexibly applied cognitive behavioral treatment for Post-Traumatic Stress Disorder (PTSD) is more effective than the psychotherapy usually provided in the clinic (called Treatment as Usual or…
- Trial name
- NCT01488539
- Testing
- STAIR/NT treatment, Treatment as Usual (TAU)
- Where
- 5 sites in United States
- Volunteers
- 210 people
- Sponsor
- Palo Alto Veterans Institute for Research
Depressive Disorder, Depression
The Role of Inflammatory Processes in Development and Treatment of Depression
The study investigates the influence of inflammatory processes on the development and the course of uni- and bipolar depression.
- Conditions
- Depressive Disorder, Depression, Inflammation
- Trial name
- INFLAME-D (NCT03920475)
- Testing
- Sertraline or venlafaxine, Immune parameters
- Volunteers
- 104 people
- Sponsor
- Kliniken Essen-Mitte
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