Postpartum Depression (PPD)MOMS-ADNCT07485036
Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms
A study testing Contingency Management & Problem Solving Therapy in people with Postpartum Depression (PPD) and Alcohol Use, run by University of Illinois Chicago at 1 site in United States.
Trial summary
This study aims to learn about depression and alcohol use in postpartum mothers and whether an intervention based on contingency management and problem-solving therapy (CM-PST) can help reduce these symptoms. The main questions it seeks to answer are: 1. Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Postpartum Depression (PPD), Alcohol Use, Contingency Management
- What is being tested?
- Contingency Management & Problem Solving Therapy
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Oct 2026to 30 Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Biologically female
- Age ≥18 years
- Within 12 months postpartum
- Able to provide informed consent
Who cannot join
- Serious medical or psychiatric conditions requiring hospitalization
- Lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or any psychiatric disorder
- Current use of psychoactive drugs, medication to treat problematic alcohol use, or depression
- Participation in past 6 months in problematic alcohol use or substance use treatment
- Unable to provide consent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Illinois Hospital and Health Sciences System, University of Illinois College of Medicine
Chicago, Illinois, 60612
Hagar Hallihan, PhD, RN, 312-413-7822, hhalli2@uic.edu
Hagar Hallihan, PhD
About this study
Official title: Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms (MOMS-AD Pilot Study)
This study aims to learn about depression and alcohol use in postpartum mothers and whether an intervention based on contingency management and problem-solving therapy (CM-PST) can help reduce these symptoms. The main questions it seeks to answer are:
- How do new mothers fare with depressive symptoms and alcohol use in the first 12 months after giving birth?
- Will a CM-PST intervention reduce depressive symptoms and alcohol use frequency among new mothers?
- Is a CM-PST intervention practical for new mothers?
Read more
The researchers will recruit approximately 30 new mothers and randomly select half to attend a 6-week CM-PST intervention. They will compare those who received the intervention versus those who did not to see if there are any differences in their depressive symptoms and alcohol usage.
Participants will:
- Complete 4 remote intervention sessions over 6 weeks
- Conduct at-home urine drug tests 2x per week during the 6-week intervention
- Answer online surveys about their mental health and alcohol use
- Being tested
- Contingency Management & Problem Solving Therapy, Usual Care
- Medical subject headings
- Depression, Postpartum, Alcohol Drinking
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Contingency Management & Problem Solving TherapyBehavioural
A 6-week online CM-PST course delivered through video conferencing calls consisting of 4 educational sessions, combined with 2x weekly at-home drug testing to monitor the reduction in alcohol use and reduced depression symptoms.
Usual CareOther
Participants randomized to the usual care condition will continue to receive standard postpartum care from their obstetrician-gynecologist, consistent with routine clinical practice. No additional psychological intervention will be provided as part of the study.
| Study group | Role | What they receive |
|---|---|---|
| Contingency Management & Problem Solving Therapy (CM-PST) Intervention Group | Experimental | Receives 4 remote sessions of CM-PST therapy over 6 weeks while conducting at home urine drug tests 2x weekly. Receives: Behavioral: Contingency Management & Problem Solving Therapy |
| Usual Care Control Group | Placebo comparator | Not described Receives: Other: Usual Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in postpartum depression symptoms
Participants will take the Edinburgh Postnatal Depression Scale (EPDS) at screening, baseline and at 3 months to assess changes in mental health and depressive symptoms. This is reported on a scale of 0-30; a higher score indicates a higher likelihood of postpartum depression.
Measured: Screening, Baseline, 3 months
Alcohol use test results
Participants' alcohol use will be monitored and assessed with urine drug tests at baseline, 2x weekly throughout the duration of the 6-week intervention, and at 3 months.
Measured: Baseline, Weekly, 3 months
Change in alcohol use screening status
Participants will take the Alcohol Use Disorders Identification Test (AUDIT) at the time of screening, baseline and at 3 months. This is reported on a scale of 0-40; a higher score indicates a higher likelihood of moderate to severe alcohol use.
Measured: Screening, Baseline, 3 months
Change in alcohol-related negative consequences
Participants will take the Rutgers Alcohol Problems Index (RAPI) at baseline and at 3 months to assess changes in problems related to alcohol use. This is reported on a scale of 0-72; a higher score indicates a higher likelihood of alcohol-related negative consequences in everyday life.
Measured: Baseline, 3 months
Change in alcohol use
Participants will take the Timeline Follow Back (TLFB) questionnaire at baseline and at 3 months to assess changes in alcohol use.
Measured: Baseline, 3 months
Change in reasons for drinking
Participants will take the Drinking Motive Questionnaire-Revised (DMQ-R) at baseline and at 3 months to assess changes in alcohol use motivations. This is reported on a scale of 20-100; a higher score indicates stronger motivations for alcohol use.
Measured: Baseline, 3 months
Secondary outcomes (3)
Acceptability of intervention
Participants will complete a 10-minute interview at the end of the intervention to assess their sentiments towards CM-PST and take the Client Counseling Satisfaction Scale (CCSS). This is reported on a five-point Likert scale of 6-30, and includes an open-ended question about suggestions for future interventions. A higher score indicates a higher likelihood of participant satisfaction.
Measured: 3 months
Feasibility of intervention via adherence
Participant adherence will be assessed by monitoring and documenting attendance for each intervention session and completion of urine alcohol screening tests.
Measured: 3 months
Feasibility of intervention via retention
Participant retention will be assessed by monitoring and calculating the proportion of the study sample retained by the end of the intervention.
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Mar 2026
- Study start1 Oct 2026 (estimated)
- Primary completion30 May 2027 (estimated)
- Study completion30 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postpartum Depression (PPD)Studies of the same condition, open and under way.
- More trials run by University of Illinois ChicagoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Illinois Chicago
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07485036
- Sponsor's protocol ID
- 2026-0112
- Acronym
- MOMS-AD
- Status last verified
- Feb 2026
- First submitted
- 18 Feb 2026
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: We will adhere to the NIH Grant Policy on Sharing of Unique Research Resources including the Principles and Guidelines for Recipients of NIH Research Grants and Contracts on Obtaining and Disseminating Biomedical Research Resources issued December 23, 1999. Data from this research will be shared and the results of this research will be made available via publication in scientific journals and through scientific meetings where our findings are reported. Publication of data shall occur during the project, if appropriate, or at the end of the project, consistent with typical scientific practices. All publications will be made publicly available consistent with NIH policies.
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms (MOMS-AD Pilot Study)
- ClinicalTrials.gov ID
- NCT07485036
- Acronym / sponsor ID
- MOMS-AD / 2026-0112
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of Illinois ChicagoUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 30 May 2027 (estimated)
- Study completion
- 30 Nov 2027 (estimated)
- First posted
- 20 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to learn about depression and alcohol use in postpartum mothers and whether an intervention based on contingency management and problem-solving therapy (CM-PST) can help reduce these symptoms. The main questions it seeks to answer are:
- How do new mothers fare with depressive symptoms and alcohol use in the first 12 months after giving birth?
- Will a CM-PST intervention reduce depressive symptoms and alcohol use frequency among new mothers?
- Is a CM-PST intervention practical for new mothers?
The researchers will recruit approximately 30 new mothers and randomly select half to attend a 6-week CM-PST intervention. They will compare those who received the intervention versus those who did not to see if there are any differences in their depressive symptoms and alcohol usage.
Participants will:
- Complete 4 remote intervention sessions over 6 weeks
- Conduct at-home urine drug tests 2x per week during the 6-week intervention
- Answer online surveys about their mental health and alcohol use
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Contingency Management & Problem Solving Therapy (CM-PST) Intervention Group | Experimental | Behavioral: Contingency Management & Problem Solving TherapyReceives 4 remote sessions of CM-PST therapy over 6 weeks while conducting at home urine drug tests 2x weekly. |
| Usual Care Control Group | Placebo comparator | Other: Usual Care |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Biologically female
- Age ≥18 years
- Within 12 months postpartum
- Able to provide informed consent
Key exclusion criteria (5 listed)
- Serious medical or psychiatric conditions requiring hospitalization
- Lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or any psychiatric disorder
- Current use of psychoactive drugs, medication to treat problematic alcohol use, or depression
- Participation in past 6 months in problematic alcohol use or substance use treatment
- Unable to provide consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Contingency Management & Problem Solving TherapyA 6-week online CM-PST course delivered through video conferencing calls consisting of 4 educational sessions, combined with 2x weekly at-home drug testing to monitor the reduction in alcohol use and reduced depression symptoms. | Behavioural | Contingency Management & Problem Solving Therapy (CM-PST) Intervention Group |
| Usual CareParticipants randomized to the usual care condition will continue to receive standard postpartum care from their obstetrician-gynecologist, consistent with routine clinical practice. No additional psychological intervention will be provided as part of the study. | Other | Usual Care Control Group |
Primary outcome
Change in postpartum depression symptoms
Time frame: Screening, Baseline, 3 months
Participants will take the Edinburgh Postnatal Depression Scale (EPDS) at screening, baseline and at 3 months to assess changes in mental health and depressive symptoms. This is reported on a scale of 0-30; a higher score indicates a higher likelihood of postpartum depression.
Alcohol use test results
Time frame: Baseline, Weekly, 3 months
Participants' alcohol use will be monitored and assessed with urine drug tests at baseline, 2x weekly throughout the duration of the 6-week intervention, and at 3 months.
Change in alcohol use screening status
Time frame: Screening, Baseline, 3 months
Participants will take the Alcohol Use Disorders Identification Test (AUDIT) at the time of screening, baseline and at 3 months. This is reported on a scale of 0-40; a higher score indicates a higher likelihood of moderate to severe alcohol use.
Change in alcohol-related negative consequences
Time frame: Baseline, 3 months
Participants will take the Rutgers Alcohol Problems Index (RAPI) at baseline and at 3 months to assess changes in problems related to alcohol use. This is reported on a scale of 0-72; a higher score indicates a higher likelihood of alcohol-related negative consequences in everyday life.
Change in alcohol use
Time frame: Baseline, 3 months
Participants will take the Timeline Follow Back (TLFB) questionnaire at baseline and at 3 months to assess changes in alcohol use.
Change in reasons for drinking
Time frame: Baseline, 3 months
Participants will take the Drinking Motive Questionnaire-Revised (DMQ-R) at baseline and at 3 months to assess changes in alcohol use motivations. This is reported on a scale of 20-100; a higher score indicates stronger motivations for alcohol use.
3 secondary outcomes
Acceptability of intervention
Time frame: 3 months
Feasibility of intervention via adherence
Time frame: 3 months
Feasibility of intervention via retention
Time frame: 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
- Individual participant dataSharing planned: Yes. We will adhere to the NIH Grant Policy on Sharing of Unique Research Resources including the Principles and Guidelines for Recipients of NIH Research Grants and Contracts on Obtaining and Disseminating Biomedical Research Resources issued December 23, 1999. Data from this research will be shared and the results of this research will be made available via publication in scientific journals and through scientific meetings where our findings are reported. Publication of data shall occur during the project, if appropriate, or at the end of the project, consistent with typical scientific practices. All publications will be made publicly available consistent with NIH policies.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Contingency Management & Problem Solving Therapy in people with Postpartum Depression (PPD) and Alcohol Use, run by University of Illinois Chicago at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hagar Hallihan, PhD, RN (312-413-7822, hhalli2@uic.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in postpartum depression symptoms (time frame: Screening, Baseline, 3 months). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.