Clinical trials: Treatment as usual
Cirrhosis, Liver, Acute Kidney Injury
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
The goal of this interventional study is to evaluate two strategies for how to provide intravenous (IV) fluids for treating patients with acute kidney injury (AKI) in cirrhosis.
- Conditions
- Cirrhosis, Liver, Acute Kidney Injury, Hepatorenal Syndrome
- Trial name
- RAKI-VAGA (NCT06525623)
- Testing
- Recommendation: No Further Resuscitation, Recommendation: Resuscitation with Crystalloid, Recommendation: Resuscitation with Colloid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Dermatitis Atopic
Observational Evaluation of Atopic Dermatitis in Pediatric Patients
Primary Objectives: To describe the characteristics of pediatric patients with moderate to severe atopic dermatitis (AD) whose disease is not adequately controlled with topical therapies or when those therapies are not medically…
- Trial name
- PEDISTAD (NCT03687359)
- Testing
- Standard of care
- Where
- 182 sites in United States, Argentina and 18 more
- Volunteers
- 1,860 people
- Sponsor
- Sanofi
Feasibility
Feasibility and Acceptability Followed by Effectiveness of bCPAP for Treatment of Bangladeshi Children With Severe Pneumonia
Background: Feasibility and acceptability of bubble continuous positive airway pressure (CPAP) were not evaluated in childhood severe pneumonia in developing countries at a larger scale. Objective: 1.
- Trial name
- Child-bCPAP (NCT05239559)
- Testing
- Bubble CPAP oxygen delivery device
- Where
- 2 sites in Bangladesh
- Volunteers
- 20 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Gestational Weight Gain, Overweight and Obesity
Healthy Gestational Weight Gain Programme
This study aims to evaluate the efficacy of a multi-component lifestyle interventions during pregnancy on promoting appropriate gestational weight gain, preventing GDM, and improving pregnancy, delivery, and neonatal outcomes…
- Trial name
- NCT06370533
- Testing
- behavioral interventions
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Cognitive Impairment, Stroke
Strategy Training on Improving Executive Functions in Persons Following Acquired Brain Injury
About two-third individuals with acquired brain injury (ABI) experience cognitive impairments. Deficits in executive functions is one of the most prevalent cognitive impairments following ABI which result in decline of recovery…
- Conditions
- Cognitive Impairment, Stroke, Acquired Brain Injury
- Trial name
- NCT04033952
- Testing
- Strategy Training
- Where
- 3 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Medical University
PTSD
Psycho-educational Tool to Prevent Psychological Sequelae Following Paediatric Intensive Care Unit Admission
To systematically evaluate an innovative directed psycho-educational intervention consisting of written specific, age-appropriate information, complemented by a follow-up targeted telephone call in order to reduce psychological…
- Trial name
- 4PICU (NCT04635449)
- Testing
- Age-specific information booklet and targeted telephone call
- Where
- United Kingdom
- Volunteers
- 288 people
- Sponsor
- Imperial College Healthcare NHS Trust
Substance Abuse
Evaluation of Web-Based Recovery Monitoring With Clinical Alerts
The specific aims of the project are to conduct a three-phase study to develop a data-driven Clinical Alert feature to the RecoveryTrack™ Concurrent Recovery Monitoring (CRM) system and test its efficacy, as follows: Phase I …
- Trial name
- NCT01465555
- Testing
- Cognitive Behavioral Intervention
- Where
- 4 sites in United States
- Volunteers
- 389 people
- Sponsor
- Treatment Research Institute
Adrenal Insufficiency
Hydrocortisone Vs Prednisolone in AI (HYPER-AID)
This study is designed to collect data on individuals with adrenal insufficiency who are changing treatments from hydrocortisone to prednisolone, or vice versa.
- Trial name
- HYPER-AID (NCT03608943)
- Testing
- There is no specific intervention other than an individual changing their treatment as part of their usual care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
CBT
Effects of Cognitive Behavior Therapy on Quality of Life in Paroxysmal Atrial Fibrillation Patients
Health-Related Quality of Life (HRQoL) was commonly impaired in atrial fibrillation patients. Depression, anxiety, and illness perception are psychological correlates of HRQoL.
- Trial name
- NCT05893615
- Testing
- Cognitive Behaviour Therapy
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Peking University People's Hospital
ADHD
RCT of EF Family Training for P ADHD
To explore the effect of executive function family training for preschool children with ADHD, providing early social psychological intervention for aiming the core impairments of ADHD.
- Trial name
- NCT04454008
- Testing
- executive function family training, treat as usual
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Personality Disorders
The Personal Concerns Inventory Study (PCI)
Services for people with personality disorders are challenged by how to engage clients in therapy. High non-completion rates have major cost-efficiency implications, but more worrying is that drop-out may be associated with…
- Trial name
- PCI (NCT01132976)
- Testing
- Personal Concerns Inventory, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- Nottinghamshire Healthcare NHS Trust
Depressive Disorder, Depression
Mindfulness Based Emotion Regulation Therapy in the Treatment of Depressive Rumination
In this study the investigators are examining the neuronal processes of a mindfulness based emotion regulation training for reducing depressive rumination.
- Conditions
- Depressive Disorder, Depression, Rumination
- Trial name
- NCT04560192
- Testing
- Mindfulness based Emotion regulation therapy (MBERT) - Treatment as usual (TAU), Treatment as usual (TAU) - Mindfulness based Emotion regulation therapy (MBERT)
- Where
- Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Paroxysmal Atrial Fibrillation
Meditation and Education That is Nurse Delivered for Symptom Management in Paroxysmal Atrial Fibrillation (PAF)
The aim of this project is to determine whether the entire intervention (Mindfulness meditation, AF education, and weekly phone visits) that is nurse delivered to individuals with paroxysmal atrial fibrillation is more effective…
- Trial name
- MEND-AF2 (NCT03834844)
- Testing
- Meditation, AF Education, Phone Calls
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Opioid-use Disorder, Substance Use Disorders
Physical Activity as Adjunct Treatment for Opioid Substitution Therapy
In terms of research, it is documented that exercise has a positive effect on mental disorders. Studies have shown positive correlations between physical and mental health, also among substance users.
- Conditions
- Opioid-use Disorder, Substance Use Disorders, Opioid Dependence
- Trial name
- NCT04496934
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital
Pterygium of Conjunctiva and Cornea, Pterygium of Both Eyes
Clinical Outcomes of Sutured Versus Sutureless Conjunctival Autograft in Primary Pterygium Excision
The goal of this study is to find out if a certain technique in pterygium excision surgery ,using no sutures, is better than the technique mostly used ,which uses sutures.
- Conditions
- Pterygium of Conjunctiva and Cornea, Pterygium of Both Eyes, Pterygium
- Trial name
- NCT06734663
- Testing
- Clinical outcomes of sutured versus sutureless conjunctival autograft in primary pterygium excision, pterygium excision and conjuctival graft suturing, pterygium excision and conjuctival graft placement by autologous blood
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Malignant Head and Neck Neoplasm, Mucositis
Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy
This randomized phase III trial studies how well gabapentin plus standard of care work compares to standard of care without Gabapentin in preventing inflammation of the mucous membranes (mucositis) in patients with stage III-IV…
- Conditions
- Malignant Head and Neck Neoplasm, Mucositis, Radiation-Induced Disorder
- Trial name
- NCT02480114
- Testing
- Educational Intervention, Gabapentin, Pain Therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Obstructive Sleep Apnea (OSA)
Tailored Treatment to Enhance Risk Perception in Sleep Apnea
Obstructive Sleep Apnea (OSA) is seen in approximately 6% of Americans. It is a serious medical condition with significant medical and psychological consequences, including diabetes, hypertension, and cardiovascular disease.
- Trial name
- NCT02314858
- Testing
- Brief Personalized Video (BPV), Non-Personalized Video (NPV), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Adenoid Cystic Carcinoma of the Salivary Gland, Adenoid Cystic Carcinoma of the Head and Neck
A Multi-omics Approach to Disclose Progression and Underlying Biology of Head and Neck Adenoid Cystic Carcinoma
The goal of this observational study is to better understand why some people with metastatic adenoid cystic carcinoma (ACC) of the head and neck have slow-growing disease while others have faster-growing or more aggressive…
- Trial name
- MAPPING-ACC (NCT07507578)
- Testing
- Standard of Care (Investigator Choice)
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Drug Use Disorders, Illicit Drug Use
Addressing Barriers to Care for Substance Use Disorder Pilot Study
The Addressing Barriers to Care for Substance Use Disorder Pilot (ABC-SUD Pilot) was a randomized pilot study that preceded a larger trial.
- Conditions
- Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
- Trial name
- ABCSUD Pilot (NCT06317987)
- Testing
- Care Navigation
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Kaiser Permanente
Glaucoma
A Trial of China Laser and Surgery Study Glaucoma in Rural China
Aims and Objectives (Quantitative) Aim: To compare the effectiveness of selective laser trabeculoplasty with trabeculoplasty in lowering the intraocular pressure in patients with medically uncontrolled open angle glaucoma in…
- Trial name
- NCT02955849
- Testing
- SLT laser
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
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