Clinical trials: Varenicline
Dry Eye, Keratoconjunctivitis Sicca
Phase 4 Study Evaluating the Safety of the Nasal Guide With Tyrvaya
The objective of this study is to determine the safety of the nasal guide when utilized to aid in the administration of Tyrvaya (varenicline solution 0.03mg) Nasal Spray
- Trial name
- NCT05918406
- Testing
- Nasal Guide
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Oyster Point Pharma, Inc.
Nicotine Dependence
Nicotine Withdrawal Symptoms and Smoking Relapse
Background: Smoking is thought to cause changes in the brain that lead to addiction and craving. Smokers who try to quit experience nicotine withdrawal symptoms that include irritability, anxiety, and difficulty concentrating.
- Trial name
- NCT01511614
- Testing
- Transcranial Direct Current Stimulation, Nicotine patch, Varenicline Pill
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation
Varenicline Versus Cytisine for Smoking Cessation in Primary Care Setting
The overall goals of this study are to 1) assess awareness of interest in the use of pharmacotherapy for smoking cessation in Croatia and Slovenia, countries in Central Europe with very high smoking prevalence, and 2) investigate…
- Trial name
- NCT04015414
- Testing
- Varenicline, Cytisine
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 352 people
- Sponsor
- University of Zagreb
Alzheimer's Disease
Evaluation of the Efficacy of Varenicline on Cognition, Safety, Tolerability and Pharmacokinetics in Subjects With Mild-to-Moderate Alzheimer's Disease
1. Assess the efficacy of varenicline, relative to placebo, on a performance based measure of cognition in patients with mild to moderate Alzheimer's disease 2.
- Trial name
- NCT00744978
- Testing
- Varenicline
- Where
- 8 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Pfizer
Cigarette Smoking, Methadone Maintenance
Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients
The objective is to provide a preliminary test of the ability of two pharmacological treatments, the nicotine nasal spray and varenicline, relative to placebos, to reduce smoking during the 4 hours following methadone dosing.
- Trial name
- NCT02147132
- Testing
- Nicotine Nasal Spray, Varenicline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Cincinnati
Smoking Cessation
A Smoking Cessation Intervention for Yale Dining Employees
The purpose of this study is to evaluate a smoking cessation program for employees at the Yale University dining hall. Two pilot dining halls and six paired dining halls (3 test and 3 control sites) will be offered a contingency…
- Trial name
- NCT02562521
- Testing
- Contingency management, Nicotine replacement therapy, Varenicline
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Tobacco Use, Tobacco Cessation
Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse
The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.
- Conditions
- Tobacco Use, Tobacco Cessation, Insomnia
- Trial name
- NCT06609369
- Testing
- Experimental health intervention, Varenicline
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Yale University
Smoking, Smoking Cessation
Hollings Cancer Center Varenicline Sampling Study
The purpose of this study is to learn what happens when people are given a free, 4-week, sample of varenicline, a smoking cessation medication.
- Conditions
- Smoking, Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette
- Trial name
- NCT03742154
- Testing
- Varenicline 0.5 MG
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation
Comparison of Conservative and Aggressive Smoking Cessation Treatment Strategies in a Vascular Surgery Office Practice
The aim of this study is to prove that the use of Bupropion with counseling works better than counseling alone for patients to quit smoking.
- Trial name
- NCT01850589
- Testing
- Aggressive Therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Trigeminal Neuralgia
RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia
The goal of this study is to evaluate if KRIYA-748 (RP-008) is safe, tolerable, and preliminary effective in treating trigeminal neuralgia (TN) when used in combination with varenicline tartrate.
- Trial name
- RELIEF (NCT07596485)
- Testing
- RP-008, Varenicline tartrate
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Kriya Therapeutics, Inc.
HIV, Sleep
Wellness Intervention for Smoking and HIV
The investigators propose to use a parallel group, randomized controlled trial to test the efficacy of a 13-week personalized approach to reducing smoking intervention versus a second approach using a different health…
- Conditions
- HIV, Sleep, Smoking Cessation, Cardiovascular Diseases
- Trial name
- (WISH) (NCT04725617)
- Testing
- Varenicline, Smoking Cessation Counseling, Health Approach 1 to Reduce Smoking
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Tobacco Use Disorder, Smoking
Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts
Bupropion and varenicline are indicated for smoking cessation. The objectives of this study are two-fold: (1) to explore the logistic feasibility of distributing bupropion and varenicline free of charge to treatment-seeking…
- Conditions
- Tobacco Use Disorder, Smoking, Smoking Cessation
- Trial name
- NCT01023659
- Testing
- bupropion, varenicline, motivational emails
- Where
- Canada
- Volunteers
- 893 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking
Long-term Varenicline Treatment for Smoking Cessation
This is a clinical study of the efficacy and safety of up to 52 weeks of varenicline therapy in conjunction with individual counseling for smoking cessation.
- Trial name
- NCT00828113
- Testing
- varenicline, Individual smoking cessation counseling
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Dependence
Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?
The aim of the present clinical trial is to investigate whether 14 weeks of treatment with a prescription medication for smoking cessation (European trade name: Champix(R); US trade name: Chantix(R)), can reduce alcohol…
- Trial name
- NCT00846859
- Testing
- varenicline (Champix/Chantix)
- Where
- 3 sites in Sweden
- Volunteers
- 162 people
- Sponsor
- Sahlgrenska University Hospital
Smoking
Smoking Cessation Program in the Preadmission Clinic: The Use of a Teachable Moment
The Objective of this study is to introduce a practically feasible multifaceted intervention in the preadmission clinic to help reduce smoking in preoperative surgical patients.
- Trial name
- NCT01243203
- Testing
- Champix
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Cannabis Dependence, Tobacco Dependence
Varenicline for Co-occurring Cannabis and Tobacco Use
Pilot, eight week, open-label, within-subject cross over trial of four weeks of standard clinical care (SCC) in an outpatient substance use disorder treatment program and four weeks of SCC and varenicline among current and former…
- Trial name
- NCT04595318
- Testing
- Standard clinical care first, followed by standard clinical care and varenicline, Standard clinical care and varenicline first, followed by standard clinical care
- Volunteers
- 7 people
- Sponsor
- Albert Einstein College of Medicine
Cigarette Smoker, Current Every Day Smoker
Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs
This trial studies biomarkers obtained by bronchoscopy (bronchoalveolar lavage and lung brushings) to determine the effect of smoking e-cigarettes on the lungs.
- Trial name
- NCT03691350
- Testing
- Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use Cessation
A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV
Many people living with HIV (PLWH) smoke. Smoking in these individuals is often undertreated. This study plans to assess the ability of various clinical pathways involving tobacco treatment medications and contingency management…
- Trial name
- SMARTTT (NCT04490057)
- Testing
- Nicotine patch, nicotine gum, nicotine nasal spray, nicotine inhaler, Varenicline or bupropion, Contingency Management
- Where
- 4 sites in United States
- Volunteers
- 323 people
- Sponsor
- Yale University
Nicotine Addiction
Pharmacogenetics of Nicotine Addiction Treatment
The purpose of this research program is to understand how a biomarker called the "nicotine metabolite ratio" (also referred to as NMR) may influence a smoker's ability to quit smoking.
- Trial name
- NCT01314001
- Testing
- Varenicline, Transdermal Nicotine
- Where
- 4 sites in United States, Canada
- Volunteers
- 1,246 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Smoking Cessation for American Indians
American Indians and Alaska Natives (AI/ANs) have the highest smoking rates of the major racial/ethnic groups in the United States, approaching 40% to 50%.1-3 In addition, this underserved population has very low smoking…
- Trial name
- NCT01106456
- Testing
- All Nations Breath of Life (ANBL), Nontailored program (NT), Pharmacotherapy
- Where
- 2 sites in United States
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Won Choi, PhD, MPH