Clinical trials: Varenicline
Depressive Disorder, Smoking
Study of Mood Effects of Varenicline (Chantix) in Depressed Outpatient Smokers
This study will assess whether varenicline (chantix) has antidepressant properties when used in addition to other psychiatric medication. It will also assess whether varenicline improves the inability to feel pleasure (i.e.
- Trial name
- NCT00525837
- Testing
- fixed dose varenicline, varenicline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Butler Hospital
Nicotine Dependence
Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-Ib (NCT02635919)
- Testing
- mSMART
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Nicotine Dependence
Varenicline for Nicotine Dependence Among Those With HIV/AIDS
Among people diagnosed with HIV/AIDS, the widespread use of highly active antiretroviral therapy (HAART) has greatly improved survival rates and changed the leading causes of death, from AIDS-related diseases to cardiovascular…
- Trial name
- NCT01710137
- Testing
- Varenicline, Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Randomized Clinical Trial to Reduce Harm From Tobacco
Using the NIH-funded Way to Health platform, the investigators will conduct this smoking cessation RCT among Vitality/Discovery beneficiaries.
- Trial name
- NCT02328794
- Testing
- E-cigarette free access, E-cigarette/NRT/Zyban/Chantix Choice, Outcome Incentive arm
- Where
- United States
- Volunteers
- 6,006 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Reduction
Switching to E-cigarettes in Smokers Not Interested in Quitting
The objectives of this application are to 1) compare short- and long-term harm reduction and abuse liability potential of a nicotine salt pod-based electronic cigarettes (EC) in adult (AA) exclusive EC, dual cig-EC, and exclusive…
- Trial name
- NCT05703672
- Testing
- Varenicline Tartrate, Electronic cigarette
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Smoking Cessation
Effect of Smoking Reduction on Endothelial Glucocalyx and Vascular Function
The integrity of endothelial glucocalyx plays a vital role in vascular permeability and inflammation. Smoking cessation is related with improved vascular function and is a key component of secondary cardiovascular prevention.
- Trial name
- NCT02307045
- Testing
- Varenicline, nicotine
- Where
- Greece
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Athens
Smoking Cessation
Smoking Relapse-Prevention Intervention for Cancer Patients
The purpose of this study is to test different ways to help cancer patients maintain their smoking abstinence. Participants may receive educational materials as part of the study.
- Trial name
- NCT01630161
- Testing
- Usual Care, Smoking Relapse Prevention for Cancer Patients (SRP-CaP)
- Where
- United States
- Volunteers
- 441 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Smoking, Pain
Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
PASS2 aims to expand upon the recently completed study (PASS intervention), which tested the telephone delivery of a cognitive behavioral intervention (CBI).
- Conditions
- Smoking, Pain, Smoking Cessation
- Trial name
- PASS2 (NCT06442514)
- Testing
- PASS2, Treatment as Usual
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- VA Office of Research and Development
Smoking, HIV Infections
Smoking Cessation Using Motivational Therapy and Varenicline
People that are infected with HIV appear to be especially susceptible to the adverse effects of cigarette smoking. The purpose of this study is to determine if quitting smoking by using a specialized smoking cessation treatment…
- Trial name
- NCT00701896
- Testing
- Varenicline tartrate, Nicotine Replacement Therapy, Biological Control
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Philip Diaz
Cigarette Smoking, Schizophrenia
Comparison of Varenicline and Placebo for Smoking Cessation in Schizophrenia
The purpose of this proposed pilot study is to examine the use of varenicline in people with schizophrenia to specifically assess tolerability and efficacy for smoking cessation.
- Trial name
- NCT00554840
- Testing
- varenicline
- Volunteers
- 16 people
- Sponsor
- University of Maryland, Baltimore
Smoking
UW-CTRI Triple Medication Smoking Cessation Study
This study will focus on enhancing future smoking cessation treatment effectiveness by piloting a potentially more powerful combination of three FDA-approved pharmacotherapies: varenicline plus combination of two types of…
- Trial name
- NCT02681510
- Testing
- Varenicline, Nicotine Transdermal Patch, Nicotine Mini
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Smoking Cessation
Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking
The primary purpose of this study is to determine whether or not varenicline will help people with cardiovascular disease quit smoking and to confirm it is safe in these patients.
- Trial name
- NCT00282984
- Testing
- Varenicline
- Where
- 39 sites in United States, Argentina and 13 more
- Volunteers
- 714 people
- Sponsor
- Pfizer
Cigarette Smoking, Nicotine Dependence
Treatment of Smoking Among Individuals With PTSD
This study will examine the effect of combining prolonged exposure, a cognitive-behavioral treatment program for post-traumatic stress disorder (PTSD) with medication (varenicline) and counseling treatments for smoking cessation.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
- Trial name
- NCT00937235
- Testing
- Varenicline, Medication Management Counseling, Prolonged Exposure
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype
Nicotine replacement therapy (NRT) is a well-tolerated and efficacious smoking cessation treatment, and yet many smokers fail to quit using NRT.
- Trial name
- ConNic3 (NCT00894166)
- Testing
- Nicotine Patches, Nicotine patches, then bupropion & nicotine patches (Pre-Quit), Nicotine patches, then varenicline (Pre-Quit)
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- Duke University
Smoking, Smoking Cessation
Alternate Nicotine Delivery Systems and Airway Epithelial Biology
Cigarette smoking evokes major changes in the biology of the airway epithelium, the cell population that takes the brunt of the stress of cigarette smoke and the cell population central to the pathogenesis of chronic obstructive…
- Trial name
- NCT01974063
- Where
- 2 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Smoking Cessation
12 Week Evaluation of the Safety and Efficacy of 4 Dosing Strategies of CP-526,555 and Placebo for Smoking Cessation.
The purpose of the study is to measure the safety and efficacy of four dosing strategies of CP-526,555 for 12 weeks compared with placebo for smoking cessation.
- Trial name
- NCT00150254
- Testing
- CP-526,555 (varenicline)
- Where
- 13 sites in United States
- Volunteers
- 625 people
- Sponsor
- Pfizer
Coronary Artery Disease
Influence of Varenicline on the Antiplatelet Action of Clopidogrel
The purpose of this study is to investigate the effects of steady-state varenicline on the antiplatelet action of clopidogrel in patients with coronary artery disease.
- Trial name
- VACL (NCT01308671)
- Testing
- Varenicline, Counseling and psychosocial support
- Where
- China
- Volunteers
- 198 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Smoking Cessation
Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program
The goal of this quality improvement program is to implement, evaluate, and sustain an evidence-based smoking cessation treatment program with a population-based approach so that all patients at the Siteman Cancer Center…
- Trial name
- NCT04107857
- Testing
- ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer, ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer, Data Driven Feedback reports
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Smoking Lapse Behavior
The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior
The purpose of this study is to examine how smoking cessation medications (varenicline, bupropion) affect the ability to resist smoking and also subsequent ad-lib smoking in non-treatment seeking daily smokers.
- Trial name
- NCT00580853
- Testing
- varenicline, bupropion
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Yale University
Nicotine Dependence
Maintaining Nonsmoking
The research is based on a chronic disorder model of cigarette smoking which suggests that long-term treatment targeted to prevent relapse may be useful.
- Trial name
- NCT01162239
- Testing
- Varenicline, Initial Individual counseling, Check-ins with medical staff
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco