Clinical trials: Varenicline
Varenicline and the Blunting of Cocaine Cues
Assessing the Impact of Varenicline on Brain-Behavior Vulnerability
Our proposal will enable us to study cocaine patients to determine whether varenicline can weaken brain arousal to drug cues in an fMRI imaging setting, which is what we theorize.
- Trial name
- NCT00895557
- Testing
- chantix
- Where
- United States
- Sponsor
- University of Pennsylvania
Smoking Cessation
Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening
To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.
- Trial name
- NCT04798664
- Testing
- Removal of Financial Barriers, Financial Incentives, Mobile Health Application
- Where
- 5 sites in United States
- Volunteers
- 3,228 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tobacco Use Disorder, Nicotine Dependence
The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Clinically proven medications such as nicotine replacement therapy, bupropion and varenicline are available to help smokers quit but there are not widely used.
- Trial name
- MATCH (NCT02146911)
- Testing
- Bupropion, Varenicline, Weekly Motivational Emails
- Where
- Canada
- Volunteers
- 968 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
12 Week Evaluation of the Safety and Efficacy of a Flexible Dose of CP-526,555 and Placebo for Smoking Cessation
The purpose of the study was to measure the safety and efficacy of a 12-week flexible dosing strategy of CP-526,555 compared with placebo for smoking cessation.
- Trial name
- NCT00150228
- Testing
- CP-526,555 (varenicline)
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Pfizer
Chronic Pain, Smoking
Peri-procedural Smoking Cessation Program in Patients With Chronic Pain
This single arm study will assess whether smoking cessation counseling offered to chronic pain patients is effective in reducing pain and cigarette use.
- Trial name
- NCT04605744
- Testing
- Smoking cessation counseling
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Cooper Health System
Pulmonary Complications, HIV Infections
Longitudinal Studies of HIV-Associated Lung Infections and Complications (Lung HIV)
The Lung HIV goal is to facilitate the data and specimen collection efforts of eight individual HIV and pulmonary studies that operate under the direction of the NHLBI.
- Trial name
- LHIV (NCT00933595)
- Testing
- Smoking Cessation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Human Immunodeficiency Virus, Smoking
Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)
Smoking is a significant cause of damage to health and quality of life specifically for Veterans with human immunodeficiency virus (HIV). Smoking cessation interventions for this population are lacking.
- Trial name
- MESH (NCT04135937)
- Testing
- Bupropion, Varenicline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
Multimodal Cue Exposure Therapy for Smoking Cessation
At two sites (Boston University and the University of Texas at Austin, under the MPI direction of Drs. Otto and Smits) the investigators propose to randomly assign 240 adult smokers who have achieved short-term abstinence…
- Trial name
- NCT04035603
- Testing
- D-Cycloserine, Open Phase CBT that preceeds the randomization phase, Open phase smoking cessation pharmacotherapy that proceeds the randomization phase
- Sponsor
- Boston University Charles River Campus
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation
A Study to Evaluate the Safety and Efficacy of Three Doses of a Controlled Release Formulation of Varenicline for Smoking Cessation
The purpose of this study is to evaluate the safety, efficacy, and tolerability of twice daily (BID) administration of three dose strengths (1.2 mg, 1.8 mg, and 2.4 mg) of varenicline controlled release (CR) tablets in adult…
- Trial name
- NCT00741884
- Testing
- Varenicline Controlled Release 1.2 mg, Varenicline Controlled Release 1.8 mg, Varenicline Controlled Release 2.4 mg
- Sponsor
- Pfizer
Smoking
Phase 1 Clinical Trial of Varenicline in Chinese Healthy Smoking Volunteers
This study is to measure how much of varenicline tartrate is in Chinese healthy smokers' blood and urine after taking a single dose and several doses respectively, and also to test the safety (the impact of the study drug on…
- Trial name
- NCT00452894
- Testing
- varenicline tartrate
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Pfizer
Dry Eye Disease
Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease
The objective of this study is to evaluate the safety and effectiveness of OC-01 Nasal Spray as compared to placebo on signs and symptoms of dry eye disease
- Trial name
- NCT03636061
- Testing
- OC-01 (varenicline) nasal spray
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- Oyster Point Pharma, Inc.
Bladder Cancer, Cervical Cancer
Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking
RATIONALE: Varenicline, the nicotine patch, and nicotine gum help people stop smoking. It is not yet known whether varenicline is more effective than the nicotine patch given together with nicotine gum in helping smokers quit…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00790569
- Testing
- nicotine, varenicline
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- Butler Hospital
Smoking Cessation
A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation
The primary purpose of this study is to evaluate the safety and efficacy of varenicline given for a twelve week treatment period in comparison with placebo and Zyban for smoking cessation.
- Trial name
- NCT00141206
- Testing
- varenicline (CP-526,555)
- Where
- 20 sites in United States
- Volunteers
- 1,005 people
- Sponsor
- Pfizer
Acute Coronary Syndrome, Smoking Cessation
Early In-hospital Initiation of Pharmacotherapy for Smoking Cessation, Patients After ACS
The hypothesis of this study is that combination of Varenicline treatment with nurse-led hospital support during hospitalization and after discharge will result in clinically significant higher long term abstinence rates in…
- Trial name
- NCT02106637
- Testing
- Varenicline
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Schizophrenia
A 6-Week Multicenter Trial Of Varenicline Tartrate For Cognitive Impairment In Subjects With Schizophrenia
The primary objective of this protocol is to assess the efficacy of two dose strengths of varenicline (0.5 mg BID and 1mg BID) as adjunctive treatment for cognitive impairment in symptomatically stable outpatient schizophrenic…
- Trial name
- NCT00743847
- Testing
- varenicline
- Sponsor
- Pfizer
Smoking Cessation, Smoking
Smoking Habits and Smoking Cessation in Young Adults
The purpose of this study is to assess the efficacy and effectiveness of varenicline and nicotine patch combined with motivational interview technique in smoking cessation of young adults over 12 months follow-up.
- Conditions
- Smoking Cessation, Smoking, Habits
- Trial name
- NCT01531049
- Testing
- varenicline, Nicotine cutaneous patch 15mg/16h, Nicotine cutaneous patch 10mg/16h
- Where
- Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tuula Toljamo
Smoking
Smoking Cessation Program in the Preadmission Clinic
This study is a randomized, double-blind, placebo-controlled clinical trial which evaluates the efficacy of preoperative smoking counseling and varenicline (a medication approved by Health Canada and FDA for quitting smoking) to…
- Trial name
- NCT00937508
- Testing
- Smoking counseling, varenicline
- Where
- Canada
- Volunteers
- 290 people
- Sponsor
- University Health Network, Toronto
Methamphetamine Addiction, Crystal Meth Addiction
An Assessment of the Safety of Varenicline in Methamphetamine-dependent Volunteers
More people worldwide use amphetamine-type stimulants than any illicit drug besides cannabis, and methamphetamine (MA) abuse and dependence is the fastest growing drug problem in the United States.
- Conditions
- Methamphetamine Addiction, Crystal Meth Addiction, Amphetamine Addiction
- Trial name
- NCT00713479
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Los Angeles
Nicotine Dependence, Smoking Cessation
Exercise or Relaxation for Smoking Cessation
This research study is being done to find out if adding a moderate exercise program or a relaxation program to a smoking cessation treatment program will improve smoking cessation and health in postmenopausal women.
- Trial name
- NCT00921388
- Testing
- Varenicline and smoking cessation counseling, Exercise or relaxation treatment
- Where
- 2 sites in United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- UConn Health