Clinical trials: Varenicline
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the bronchi with an increasing prevalence. By 2020, the mortality related to COPD is expected to become the 3rd leading death worldwide.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Smoking
- Trial name
- SAVE (NCT01694732)
- Testing
- Varenicline
- Where
- 13 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Alcoholism, Alcohol Abuse
Varenicline Treatment of Alcohol Dependence in Smokers
The purpose of this study is to determine whether varenicline is effective in the treatment of alcohol dependence in smokers.
- Conditions
- Alcoholism, Alcohol Abuse, Smoking, Alcohol Drinking
- Trial name
- NCT01553136
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Yale University
Dry Eye Disease
Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease
The objective of this study is to evaluate the safety and effectiveness of OC-01 (varenicline solution) Nasal Spray as compared to placebo (vehicle) on signs and symptoms of dry eye disease.
- Trial name
- NCT05378945
- Testing
- Varenicline Tartrate Nasal Spray
- Where
- 20 sites in China
- Volunteers
- 340 people
- Sponsor
- Corxel Pharmaceuticals
Tobacco Use Disorder
Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit
The investigators will randomize smokers to receive 1) Varenicline + smoking cessation/reduction counseling or 2) Placebo pill + smoking cessation/reduction counseling.
- Trial name
- NCT01308736
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Tobacco Use
Tobacco Cessation Treatment Preferences Among Veteran Smokers
There are significant barriers to tobacco cessation treatment for patients and providers in specialty care clinical settings. Specialty providers cite several barriers to delivering evidence-based tobacco cessation care…
- Trial name
- MESH (NCT05277207)
- Testing
- Personalized Smoking Cessation Facilitation Meetings, Personalized Smoking Cessation Pharmacotherapy, Personalized Text Messaging Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Rheumatoid Arthritis
Effect of Controlling Environmental Risk Factors in Established RA
The factors contributing to the development of rheumatoid arthritis are multiple, with a role of the environment and a predisposing genetic background.
- Trial name
- DISRUPT-estRA (NCT05198271)
- Testing
- Management of risk factors, Smoking cessation, weightloss
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Cannabis Abuse
Varenicline as a Treatment for Cannabis Use Disorder
Marijuana is the most commonly used illicit drug, and there is a high demand for effective treatments for cannabis use disorder, yet few specific pharmacological treatments have been developed.
- Trial name
- NCT07783555
- Testing
- Varenicline (Chantix)
- Volunteers
- 224 people
- Sponsor
- Medical University of South Carolina
Tobacco Dependence
Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users
Primary aim: Will varenicline be better than placebo to get long-term users of NRT to stop? Secondary aim: To assess in details some side effects of varenicline i.e. nausea and abnormal dreams.
- Trial name
- NCT00977249
- Testing
- support and visits, varenicline
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Smoking Cessation
Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.
Non-treatment extension to study A3051123, aimed at collecting data on cardiovascular safety for all participants in the A3051123 trial for an additional 28 weeks, allowing for a total of 52 weeks of cardiovascular safety data…
- Trial name
- CATS (NCT01574703)
- Testing
- varenicline tartrate, bupropion hydrochloride, Nicotine Replacement Therapy Patch
- Where
- 134 sites in United States, Argentina and 14 more
- Volunteers
- 4,595 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Tobacco Use Disorder, Nicotine Dependence
A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control
Background: Chronic nicotine exposure through cigarette smoking affects the level of the brain chemical dopamine. Smokers who attempt to quit experience lower levels of dopamine, which increases anxiety and triggers nicotine…
- Trial name
- NCT00830739
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Tobacco Use Disorder
E-cigarette Cessation in Adults Who Co-use Cannabis
The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis.
- Trial name
- VapeCAT (NCT06688539)
- Testing
- Varenicline Pill, Contingency management, Counseling
- Where
- 3 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking Cessation, Depression
Efficacy of Exercise and Counseling Intervention on Relapse in Smoker With Depressive Disorders
This study investigated the efficacy of an exercise and counseling intervention for depressed smokers (depression subscale of the Hospital Anxiety and Depression Scale, HADS-D score ≥ 8) in term of likelihood of smoking…
- Trial name
- STOB-ACTIV (NCT01401569)
- Testing
- Exercise and counseling (for smoking cessation and physical activity)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Smoking Cessation, Health Behavior
So-Lo-Mo Intervention Applied to the Smoking Cessation Process
This is a randomized open-label parallel-group trial. 240 subjects will be recruited during 8 months and a 12 months follow-up will be carried out for each one of them.
- Conditions
- Smoking Cessation, Health Behavior, Lifestyle-related Condition
- Trial name
- So-Lo-Mo (NCT03553173)
- Testing
- So-Lo-Mo, Psychological advice, Bupropion Pill
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Smoking Cessation
Smoking Cessation in Subjects With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD).
This study is to be conducted in subjects with mild-to-moderate COPD who are cigarette smokers with the intent of demonstrating differences in smoking cessation between varenicline and placebo.
- Trial name
- NCT00285012
- Testing
- Varenicline Tartarate
- Where
- 32 sites in United States, France and 2 more
- Volunteers
- 504 people
- Sponsor
- Pfizer
Tobacco Use Disorder
Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness
Seventy to eighty percent of Veterans experiencing homelessness (VEH) smoke, which is four times the rate of the U.S. population and 2.5 times higher than among impoverished Americans.
- Trial name
- New HART (NCT07714200)
- Testing
- Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation, Alcohol Drinking
Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation
The purpose of this study is to learn if the combination of a study drug and patch is more effective in helping heavy drinkers stop smoking than just the patch alone The study drug, varenicline, has been approved by the Food and…
- Trial name
- NCT02859142
- Testing
- Chantix, Behavioral Counseling Sessions, NicodermCQ
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Tobacco Use Disorder, Tobacco Use Cessation
Efficacy of Varenicline in Ambivalent Smokers
The purpose of this study is to test whether Varenicline can help ambivalent smokers (those who are interested in quitting at some point in the future but have no current plans to quit) to reduce their smoking and eventually quit.
- Conditions
- Tobacco Use Disorder, Tobacco Use Cessation, Nicotine Dependence
- Trial name
- NCT00595868
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Cigarette Smoking, E-Cigarette Use
Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
The purpose of this research study is to understand whether concurrent treatment for cigarettes and e-cigarettes in which an individual quits both products at the same time (QUIT-C) or sequential treatment in which an individual…
- Conditions
- Cigarette Smoking, E-Cigarette Use, Smoking Cessation
- Trial name
- NCT06027840
- Testing
- Varenicline, Counseling, Guided Self-Change Booklets
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Yale University