Clinical trials: Vehicle, open to volunteers
Risk Reduction Behavior, Injuries
Driver Education Research Study
This study will test the effectiveness of different types of driver training interventions for reducing young new driver crash risk early after licensure.
- Conditions
- Risk Reduction Behavior, Injuries, Accident, Traffic, Development, Adolescent
- Trial name
- DRIVER (NCT06413927)
- Testing
- Online Vehicle and Driver Safety Education, Online Driver Skills Training, Behind-the-Wheel Driver Training
- Where
- United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Cutaneous T-Cell Lymphoma, Mycosis Fungoides (MF)
Efficacy and Safety of Benvitimod Cream in Cutaneous T-Cell Lymphoma
Background: CTCL is a rare type of non-Hodgkin lymphoma that primarily affects the skin, causing red patches, plaques, and severe itching.
- Trial name
- BEST-CTCL (NCT07658924)
- Testing
- Benvitimod Cream
- Volunteers
- 35 people
- Sponsor
- Peking University First Hospital
Lichen Sclerosus
A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus
The main objective of the study is to evaluate the efficacy of twice daily applications of delgocitinib cream compared with cream vehicle in the treatment of adult participants with mild to severe lichen sclerosus (LS).
- Trial name
- DELTA CARE 1 (NCT07335588)
- Testing
- Delgocitinib, Cream Vehicle
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 652 people
- Sponsor
- LEO Pharma
Tinea Pedis
Topical Tolnaftate Stick for Tinea Pedis: An Open-Label Interventional Study
This study is designed to evaluate the safety and effectiveness of multiple 1% tolnaftate formulations delivered through novel stick-based vehicles in individuals with tinea pedis (athlete's foot).
- Trial name
- NCT07245667
- Testing
- 1% Tolnaftate Stick Formula A, 1% Tolnaftate Stick Formula B, 1% Tolnaftate Stick Formula C
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Propedix, Inc.
Enterobacteriaceae Infections, Fecal Microbiota Transplantation
Fecal Transplantation to Eradicate Colonizing Emergent Superbugs
Carriage of multi-drug and extensive-drug resistant Gram negative bacteria (MDR-GNB) is associated with an increased risk of infections by these bacteria for the carriers and a high risk of dissemination both in the healthcare…
- Trial name
- FECES (NCT05035342)
- Testing
- Fecal Microbiota Transplantation (FMT) capsules
- Where
- 11 sites in France
- Volunteers
- 214 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aging
Transient Receptor Potential Channels
Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili…
- Trial name
- TRP (NCT06444594)
- Testing
- TRPM8 Agonist, TRPV1 Agonist, TRPV4 Agonist
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Penn State University
Parkinson, Multiple Sclerosis
Driving Performance in Parkinson's Disease and Multiple Sclerosis Using a Driving Simulator
This prospective observational study investigates whether driving performance measured in a standardized driving simulator differs between people with Parkinson's disease, people with multiple sclerosis, and healthy drivers.
- Trial name
- NeuroSimDrive (NCT07809828)
- Testing
- Standardized Driving Simulator Assessment
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Eosinophilic Esophagitis
A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).
A Phase 1b/2 study to explore the safety, efficacy and pharmacokinetics of EP-104GI in adults with eosinophilic esophagitis (EoE).
- Trial name
- RESOLVE (NCT05608681)
- Testing
- EP-104GI, Matching vehicle control
- Where
- 23 sites in Australia, Canada and 4 more
- Volunteers
- 117 people
- Sponsor
- Eupraxia Pharmaceuticals Inc.
Persistent Corneal Epithelial Defect
A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
This study is to evaluate the safety and efficacy of NEXAGON® (lufepirsen ophthalmic gel) (NEXAGON) in subjects with persistent corneal epithelial defects (PCED).
- Trial name
- NEXPEDE-1 (NCT05966493)
- Testing
- lufepirsen high dose, Vehicle, lufepirsen low dose
- Where
- 28 sites in United States, Germany and 2 more
- Volunteers
- 84 people
- Sponsor
- Glaukos Corporation
B-Cell Lymphoma, B Acute Lymphoblastic Leukemia
Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia
This trial aims to demonstrate the feasibility of this approach to reliably generate product and to safely administer the product to patients who have B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia.
- Conditions
- B-Cell Lymphoma, B Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, Mantle Cell Lymphoma
- Trial name
- NCT05281809
- Testing
- Chimeric Antigen Receptor (CAR) T-Cell Product (Autologous)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John Lister
Coronary Disease
Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG
Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials…
- Trial name
- L-RIPC-CABG (NCT04779008)
- Testing
- remote ischemic preconditioning （RIPC）
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Giant Axonal Neuropathy (GAN)
Intraneural Administration of scAAV9/JeT-GAN Into the Vagus Nerve for Patients With Giant Axonal Neuropathy (GAN)
Giant axonal neuropathy (GAN) is a rare pediatric disorder caused by autosomal recessive mutations in the GAN gene. GAN is a multisystem, neurodegenerative disorder affecting the peripheral nervous system (PNS), central nervous…
- Trial name
- NCT07543991
- Testing
- scAAV9/JeT-GAN
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Texas Southwestern Medical Center
Pilonidal Disease, Pilonidal Disease of Natal Cleft
Topical Anti-Androgens in Pilonidal Sinus Disease
The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft.
- Conditions
- Pilonidal Disease, Pilonidal Disease of Natal Cleft, Pilonidal Sinus, Pilonidal Cyst
- Trial name
- NCT06286397
- Testing
- 1% Clascoterone, Vehicle Cream
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Pennsylvania
Stasis Dermatitis
Short and Ultra-short-pulse ND: YAG 1064nm Lasers (Omer Smart and Omer Premium) for Stasis Dermatitis
This study tests two types of lasers (ND YAG 1064 short and ultra-short pulses) to treat hyperchromic skin lesions secondary to venous hypertension (stasis dermatitis)
- Trial name
- SUPERSTAR (NCT06980961)
- Testing
- short-pulse ND: YAG 1064 laser, ultra-short-pulse ND: YAG 1064 laser, cold cream
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Science Valley Research Institute
Parkinson Disease, Healthy Adult Participants
Brain Dopamine Biomarker
This study is being conducted at the Morsani College of Medicine to determine whether signals recorded from the eyes and brain can be used as a noninvasive way to monitor dopamine function.
- Trial name
- B3-4D (NCT07748715)
- Testing
- Levadopa/Carbidopa eyedrops, Levodopa/Carbidopa (Sinemet)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Atopic Dermatitis
A Multicenter, Randomized, Double-blind, Vehicle Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of VC005 Gel in Adult Subjects With Mild to Moderate Atopic Dermatitis
This is a multicenter, randomized, double-blind, vehicle controlled phase II clinical study to evaluate the efficacy and safety of VC005 gel in adult subjects with mild to moderate atopic dermatitis
- Trial name
- NCT07598383
- Testing
- VC005 group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Acute Standardized Cutaneous Wounds (Punch-biopsy Wounds)
Topical GHK-Cu Gel for Acute Skin Wound Healing
This study will evaluate whether a topical gel containing GHK-Cu (a copper(II)-peptide complex) can safely speed up healing of small, standardized skin wounds in healthy adults compared with a matching vehicle gel.
- Trial name
- CuHeal (NCT07437586)
- Testing
- GHK-Cu Gel (Copper(II)-peptide complex)
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hudson Biotech
Atopic Dermatitis
A Study to Assess the Efficacy and Safety of PG-011 Gel in Adolescents and Adults With Atopic Dermatitis
This is a Multicenter, Randomized, Double-blind, Placebo-controlled seamless and adaptive-designed phase IIb/III study to Assess the Efficacy and Safety of topical use of PG-011 Gel in adolescents and Adults With Atopic…
- Trial name
- NCT06587685
- Testing
- PG-011Gel, Vehicle
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Prime Gene Therapeutics Co., Ltd.
Health Adult Subjects
An Early-stage Clinical Trial to Evaluate the Safety, Absorption, and Disposition of YR001 Ointment Following Topical Application on the Skin of Healthy Chinese Subjects
The goal of this clinical trial is to evaluate the safety, local tolerability, and pharmacokinetic (PK) profile of YR001 Topical Ointment in healthy Chinese participants.
- Trial name
- NCT07673458
- Testing
- PA032, Vehicle Ointment
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hangzhou Yirui Pharmaceutical Technology Co., Ltd