Clinical trials: Vitamin C
Bowel Cleansing in Preparation for Colonoscopy
PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation
The colonoscopy accuracy and safety depend on the quality of colon cleansing. An inadequately prepped bowel will increase the risk of missing a lesion, prolong procedure, increase patient discomfort, and eventually increase…
- Trial name
- NCT01788709
- Testing
- preparation cleaning solution
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- American University of Beirut Medical Center
Acne Scars
The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Acne Scars
Our study involves the evaluation of a high potency chemical peel in its efficacy and safety profile for the treatment of acne scars.
- Trial name
- NCT02126657
- Testing
- 70% glycolic acid
- Where
- Singapore
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Hepatitis C
Can Vitamin D Supplementation Improve Hepatitis C Cure Rates
Evidence suggests that vitamin D may be directly or indirectly a co-factor for the efficacy of Hepatitis C virus, (HCV), antiviral therapies.
- Trial name
- ViaDUCT (NCT02053519)
- Testing
- Active Comparator: Vigantol Oil (Vitamin D3), Mygliol Oil
- Where
- 8 sites in United Kingdom
- Volunteers
- 72 people
- Sponsor
- University of Dundee
Fatigue
Intravenous Ascorbic Acid in Women Receiving Adjuvant or Neo-Adjuvant Chemotherapy for Early Stage Breast Cancer
This is a parallel-track, randomized study will observe whether intravenous ascorbic acid reduces the reported fatigue in women receiving adjuvant or neo-adjuvant chemotherapy for early stage breast cancer.
- Trial name
- NCT02521077
- Testing
- Ascorbic Acid, Normal Saline
- Sponsor
- Midwestern Regional Medical Center
Iron Deficiency Anemia, Inflammatory Bowel Disease
Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by chronic inflammation limited to the mucosal layer of the colon. Anemia is a consistent clinical feature of IBD.
- Trial name
- NCT02774057
- Testing
- Captafer®, Iron Sulfate
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- American University of Beirut Medical Center
Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension
: Vascular Function in Health and Disease
Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure, Hypertension
- Trial name
- NCT02966665
- Testing
- Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- D. Walter Wray
Healthy Volunteers, hATTR Amyloidosis
Evaluate the Safety and Tolerability, as Well as the Pharmacokinetic and Pharmacodynamic Profiles of Single and Multiple Doses of Eplontersen Administered Subcutaneously to Healthy Volunteers and Patients With Hereditary Transthyretin-Mediated Amyloidosis (hATTR ).
To evaluate the safety and tolerability, as well as the pharmacokinetic and pharmacodynamic profiles of single and multiple doses of Eplontersen administered subcutaneously to healthy volunteers and patients with Hereditary…
- Trial name
- NCT03728634
- Testing
- ION-682884, Vitamin A
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Diabetes, Fatty Liver
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women
Background: Vitamin E is an antioxidant that reduces the damaging effects of oxygen in the body. Most American men (90%) and women (96%) do not get enough vitamin E from their diets; however, the amount of vitamin E needed by the…
- Conditions
- Diabetes, Fatty Liver, Obesity, Healthy Volunteers
- Trial name
- NCT00862433
- Testing
- Alpha tocopherol, Vitamin E, Vitamin C
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
COVID19
International ALLIANCE Study of Therapies to Prevent Progression of COVID-19
COVID-19 is a global pandemic. So far encouraging results have been shown in different parts of the world with the utilisation of hydroxycloroquine, zinc, and azithromycin, and early studies into some of these, plus some with…
- Trial name
- NCT04395768
- Testing
- Vitamin C, Hydroxychloroquine, Azithromycin
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- National Institute of Integrative Medicine, Australia
Ultraviolet B Radiation, Microvesicle Particles
UVB-Induced MVP Release in Human Skin
This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.
- Trial name
- NCT05734235
- Testing
- Vitamin C, Vitamin E
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Wright State University
Influenza, Common Cold
A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies
The study is designed to investigate whether paracetamol from a hot remedy reaches the plasma faster than standard paracetamol tablets.
- Trial name
- NCT01332578
- Testing
- Paracetamol, Phenylephrine, Ascorbic Acid
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV/AIDS
Multi-vitamins, HAART and HIV/AIDS in Uganda
The investigators are conducting a double-blind, placebo controlled,randomized trial of multivitamin supplements(containing B-vitamins, C, and E) to determine their efficacy in slowing disease progression, indicated by increased…
- Trial name
- NCT01228578
- Testing
- Multivitamin supplements B,C and E
- Where
- Uganda
- Volunteers
- 400 people
- Sponsor
- Harvard School of Public Health (HSPH)
Metastatic Pancreatic Cancer
High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer
The purpose of this study is to see if a combination of paclitaxel protein bound (also known as nab-paclitaxel), gemcitabine, and cisplatin when given with high dose Ascorbic Acid will be safe and effective in individuals with…
- Trial name
- NCT03797443
- Testing
- Ascorbic Acid, nab paclitaxel, Cisplatin
- Where
- 3 sites in United States
- Sponsor
- Piedmont Cancer Institute
Pelvic Organ Prolapse
Systemic Markers of Collagen Metabolism and Vitamin C in Smokers and Non-Smokers With Pelvic Organ Prolapse
Data on smoking and POP are conflicting. In a study done by Alnaif et al, smoking was found to be associated with severe POP. The authors' proposed explanation was that smoking impairs tissue and wound healing.
- Trial name
- NCT01548105
- Testing
- Blood draw for the study participants
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Type 1 Diabetes
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).
- Trial name
- SAFEGUARD (NCT07187531)
- Testing
- High Dose SAB-142, Low Dose SAB-142
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 159 people
- Sponsor
- SAb Biotherapeutics, Inc.
Glioblastoma, Glioma
Bevacizumab and Ascorbic Acid in Patients Treating With Recurrent High Grade Glioma
This phase I trial studies the side effects and best dose of ascorbic acid when given together with bevacizumab in treating patients with high grade glioma that has come back (recurrent).
- Trial name
- NCT02833701
- Testing
- Ascorbic Acid, Bevacizumab, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Nebraska
Inguinal Hernia
Effects of Oral Supplementation of Arginine, Zinc and Vitamin C on Collagen Synthesis in Inguinal Hernia Patients
Collagen synthesis is depressed systemically in the immediate postoperative period. Arginine, zinc and vitamin C impact collagen synthesis.
- Trial name
- NCT03221686
- Testing
- Intervention, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Lars Nannestad Jorgensen
Pancreatic Neoplasms, Pancreatic Cancer
Clinical Trial of High-dose Vitamin C for Advanced Pancreatic Cancer
This is a phase II study. It is designed to provide information about if high-dose ascorbate (vitamin C) increases survival for pancreatic cancer patients.
- Trial name
- PACMAN-II (NCT01515046)
- Testing
- Gemcitabine with escalating ascorbic acid
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph J. Cullen
Anemia
Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysis
Among patients with chronic kidney disease (CKD), there is association between anemia and increased chance of mortality mainly because of cardiovascular diseases and stroke, risk of hospitalization, and death prevalence in…
- Trial name
- NCT02780505
- Testing
- vitamin c
- Volunteers
- 66 people
- Sponsor
- Shiraz University of Medical Sciences
Acute-on-Chronic Liver Failure (ACLF)
Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial
This study is testing whether Vitamin C can help improve kidney function and survival in very sick patients with liver disease. Patients with acute-on-chronic liver failure (ACLF) often develop serious infections that can lead to…
- Trial name
- VITAKI-ACLF (NCT07184866)
- Testing
- Vitamin C, Standard of Care (SOC)
- Volunteers
- 110 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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