Clinical trials: Water, completed
Solid Tumours
Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer
The purpose of this study is to determine whether AZD1775 has any effect on the pharmacokinetics (PK) of three compounds (caffeine, omeprazole, and midazolam) that are probes for common drug-metabolizing enzymes (caffeine-CYP1A2…
- Trial name
- NCT03333824
- Testing
- CYP1A2 (caffeine), CYP2C19 (omeprazole), CYP3A (midazolam)
- Where
- 7 sites in United States
- Volunteers
- 33 people
- Sponsor
- AstraZeneca
Xerostomia
The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia
The study is designed to evaluate the clinical efficacy of thyme honey as a mouth rinse in the management of polypharmacy-induced xerostomia concerning the unstimulated whole salivary flow rate and quality of life of patients…
- Trial name
- NCT06201923
- Testing
- Honey Mouthwash, Normal saline
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Back Pain, Neck Pain
Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure
Low back and neck pain are among the leading causes of medical visits, lost productivity and disability. There is an urgent need to identify effective and efficient ways of helping subjects with acute spine pain while guiding…
- Trial name
- SPINE CARE (NCT03083886)
- Testing
- Identify, Coordinated, Enhanced (ICE) Decision Making + PCP led care, Individualized Postural Therapy (IPT) + PCP led care, Usual PCP led care
- Where
- 8 sites in United States
- Volunteers
- 3,087 people
- Sponsor
- Brigham and Women's Hospital
Sebaceous Hyperplasia
Investigating the Effect of Topical Imiquimod on Sebaceous Hyperplasia
This study is being completed to determine if 8 weeks of treatment with imiquimod can shrink sebaceous hyperplasia.
- Trial name
- NCT06840470
- Testing
- Imiquimod 5% Topical Cream
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan
Healthy
Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly
This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.
- Trial name
- NCT01415973
- Testing
- 3 ounces of cooked, 85% lean ground beef, 20 grams beef protein isolate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Burns, Hypertrophic Scar
Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar
Laser treatment of hypertrophic burn scars has become increasingly popular for improving scarring in burn survivors. Despite its common use, there a gap in knowledge regrading randomized control trials that demonstrate whether…
- Trial name
- NCT03692273
- Testing
- Luminis ultrapulse fractional ablative carbon dioxide laser, 0.5mm punch biopsy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Cognitive Performance, Physical Performance Enhancement
Effects of Caffeine and L-Theanine on Physical and Cognitive Performance in Trained Athletes
The aim of this clinical trial is to examine how caffeine and L-theanine, taken alone or together, affect both physical and cognitive performance in healthy, trained athletes.
- Conditions
- Cognitive Performance, Physical Performance Enhancement, Caffeine and L-theanine Interaction
- Trial name
- NCT07268573
- Testing
- Caffeine, L-theanine, Combined Caffeine and L-Theanine
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ulaş Can YILDIRIM
Exploratory Behavior
The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity
Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by…
- Trial name
- NCT01918566
- Testing
- tap water, Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube, Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Food Hypersensitivity
Food Allergy Diagnostic Test Response to Previous Oral Challenge Response
The objective of this study is to compare the ocular response to CAC (using food allergen sensitive patients) to the systemic response of a previously performed oral food allergen challenge in the same subjects.
- Trial name
- NCT03693456
- Testing
- Conjunctival Allergen Challenge
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Clinical Pharmacology
Single Dose Escalation Study to Investigate the Pharmacokinetics as Well as Safety and Tolerability of a Concomitant Administration of Nifedipne GITS and Candesartan Tablets Under Fasting Conditions in Healthy Male Subjects in an Open Label, Non-randomized, Sequential Design.
The objective of the study was to investigate the pharmacokinetics as well as safety and tolerability of a concomitant administration of nifedipine GITS and candesartan tablets under fasting conditions in healthy male subjects.
- Trial name
- NCT03136666
- Testing
- Nifedipine gastrointestinal therapeutic system (GITS) (Adalat LA, BAY a1040) + Candesartan cilexetil
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bayer
Distal Radius Fracture
Telerehabilitation in Distal Radius Fracture
Objective: To determine the effectiveness of telerehabilitation versus supervised therapy in the functional recovery of patients with distal radius fracture.
- Trial name
- NCT05332080
- Testing
- Telerehabilitation via application on cell phone
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Instituto Mexicano del Seguro Social
Complete Denture, Complete Edentulism
Oral Health-related Quality of Life and Masticatory Function After Using Denture Adhesive and Denture Liner
80 complete denture (CD) wearers participated in the quasi-experimental study. Two outcomes were: 1) oral health-related quality of life (OHRQoL) assessed using the Oral Impacts on Daily Performances index, and 2) masticatory…
- Trial name
- NCT04942262
- Testing
- denture adhesive (Polident®, GlaxoSmithKline, Ireland)
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Diabetes Mellitus
A Study to Evaluate Drug-drug Interactions and Safety Between "BR3006-1", "BR3006-2", and "BR3006-3" in Healthy Volunteers
The purpose of this clinical trial is to evaluate drug-drug interactions and safety between "BR3006-1", "BR3006-2", and "BR3006-3" in healthy volunteers
- Trial name
- NCT05951946
- Testing
- BR3006-1, BR3006-2, BR3006-3
- Where
- South Korea
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Enteral Feeding Intolerance
Ultrasound Meal Accommodation Test for Enteral Feeding in the Critically Ill
Within the context of intensive care units (ICU), enteral nutrition (NE) is an essential tool in the management of critical patients.
- Trial name
- UMATI (NCT03851354)
- Testing
- Ultrasound meal acommodation test
- Where
- Mexico
- Volunteers
- 61 people
- Sponsor
- Grupo Mexicano para el Estudio de la Medicina Intensiva
Rheumatoid Arthritis
Efficacy of JAK STAT Pathways Inhibitors in Treatment of Patients With Rheumatoid Arthritis
There is no treatment that could utterly cure Rheumatoid arthritis (RA), but the disease is mainly improved by conventional disease-modifying anti rheumatic drugs.
- Trial name
- NCT05788705
- Testing
- Green Tea Polyphenolics (EGCG), Chamomile (Matricaria recutita), Licorice
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Adel A.Gomaa
Dental Health, Caries
Efficacy of Proximal Caries Infiltration
The goal of the project is to investigate the clinical efficacy of management of early caries lesions by resin infiltration and to further scrutinize the patient stress experiences.
- Trial name
- NCT01726179
- Testing
- Resin infiltration, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Chickenpox Vaccines
A Phase III Clinical Trial Assessing the Immunogenicity and Safety of Lyophilized Live-Attenuated Varicella Vaccine in Healthy Subjects Aged 13 to 55 Years
Immunogenicity and Safety of a Live Attenuated Varicella Vaccine in Adolescents and adults Aged 13-55 Years: A Phase III, Randomized, Double-Blind, Active-Controlled Study
- Trial name
- NCT06592456
- Testing
- Chickenpox Vaccines
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Lower Urinary Tract Dysfunction
Urodynamic Assessment of the Lower Urinary Tract: Water vs. Air - Synchrony
Comparison of water-perfused (WP) and air-charged (AC) catheters for invasive urodynamic investigation (UDI) regarding consistency, features and artifacts.
- Trial name
- NCT04036123
- Testing
- Urodynamic investigation
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4
Effect of Broccoli Sprout Extract in Patients With Chronic Kidney Disease With Diabetes Type 2
This research project aims to test if sulforaphane, administered as broccoli sprout extract (BSE) can ameliorate glucose control in adult patients with chronic kidney disease (CKD) and DM 2 with GFR > 15 < 45 ml/min/1.73 m2.
- Conditions
- Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4, Diabetes Mellitus, Type 2
- Trial name
- INITIATE (NCT04858854)
- Testing
- Sulforaphane, administered as Broccoli sprout extract
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Mandibular Prosthesis User
Assessment of the Impact of Probiotics on Biofilm Formation on Removable Acrylic Dentures
The aim of this study is to evaluate the effect of PIP toothbrush cleaner® on the microbial composition and Candida albicans colonization of denture biofilm formation.
- Trial name
- NCT02736994
- Testing
- PIP toothbrush cleaner® (Chrisal, Lommel, Belgium)., Corega Tabs Anti-bacteria®, Water
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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