Clinical trials: Water, completed
Magnesium Sulfate - PPHN
Treatment of Persistent Pulmonary Hypertension in Neonates With Nebulized Magnesium Sulfate
we conducted this study to compare between effect of nebulized and intravenous magnesium sulfate (MgSO₄) for better treatment of persistent pulmonary hypertension of neonates with less side effects.
- Trial name
- PPHN (NCT06603766)
- Testing
- IV Magnesium Sulfate, Inhalational magnesium sulfate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Premedication, Anaesthesia
Melatonin Premedication in Children Undergoing Surgery
Melatonin has been proposed as alternative to midazolam as a premedication in procedures preceding anaesthesia induction. The objective of this prospective, randomized, double-blind study is to investigate the possible effect of…
- Trial name
- NCT02265822
- Testing
- melatonin in children premedication, midazolam in children premedication
- Volunteers
- 92 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Hookworm Infections
Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm
The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.
- Trial name
- CHEW_MEB_PEMBA (NCT03995680)
- Testing
- Mebendazole
- Where
- Tanzania
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Type 2 Diabetes, Obesity
Pilot Sugar Reduction Intervention in Kiritimati Teenagers
Kiritimati is an isolated coral atoll in the Pacific Ocean, and is one of 32 islands that comprise the Republic of Kiribati. Obesity and type 2 diabetes rates are high in Kiribati, but the causes and rates of childhood…
- Trial name
- NCT04319003
- Testing
- Sugar-reduction intervention
- Where
- 2 sites in United States, Kiribati
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Healthy Subjects
Study to Evaluate Drug-drug Interactions of Guaifenesin and Hydrocodone Bitartrate
Determine and compare the plasma concentrations and safety and tolerability of Guaifenesin and hydrocodone bitartrate when they are administered alone or in combination to normal healthy male and/or female subjects.
- Trial name
- NCT03642873
- Testing
- Humibid®, Hydrocodone Bitartrate, Humibid® and Hydrocodone Bitartrate tablet
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser LLC
Esophageal Neoplasms
Nutritional Route In Esophageal Resection Trial II
The aim of this study is to investigate the effects of early start versus delayed start of oral intake on postoperative functional recovery after an esophagectomy.
- Trial name
- NUTRIENTII (NCT02378948)
- Testing
- Liquid oral feeding
- Where
- 2 sites in Netherlands
- Volunteers
- 148 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Esophageal Food Bolus Obstruction
Esophageal Food Impaction
This study is designed to obtain data on the safety and efficacy of oral nitroglycerin solution for the treatment of esophageal food impaction in patients presenting to the Emergency Department with presumed esophageal food…
- Trial name
- ONEFIT (NCT03305848)
- Testing
- Nitrostat 0.4Mg Sublingual Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- HealthPartners Institute
Prostatic Hyperplasia
A Study Assessing a Range of Formulations of the Fixed Dose Combination Product Containing Dutasteride (0.5mg) and Tamsulosin Hydrochloride (0.2mg) to Find a Formulation Which is Bioequivalent to Harnal-D Tablets (Tamsulosin Hydrochloride, 0.2mg) in Healthy Male Subjects From North East Asia
This study is an open-label, randomized, single dose, multi-stage, cross-over study in healthy male subjects of North East Asian ancestry.
- Trial name
- NCT01495026
- Testing
- Dutasteride (0.5mg, fasted state), Dutasteride (0.5mg, fed state), Fixed dose combination capsule containing dutasteride 0.5mg and tamsulosin 0.2mg (fasted state)
- Where
- Australia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stomatitis, Oral Mucositis
Efficacy of SNX-1012 in the Treatment of Oral Mucositis
Oral mucositis (OM) is a common and debilitating toxicity induced by many chemotherapy (CT) regimens and by radiation to the head and neck.
- Trial name
- NCT00385515
- Testing
- SNX-1012 (meclocycline sulfosalicylate)
- Where
- 27 sites in United States, India
- Volunteers
- 81 people
- Sponsor
- Mucosal Therapeutics
Atrophy, Muscular
A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days
The primary objective is to determine the pharmacokinetics, safety and tolerability of SRT2104 in healthy elderly subjects following single and 28 days dosing. The secondary objectives of the study are: 1.
- Trial name
- NCT00964340
- Testing
- SRT2104
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19, Children, Only
Water and Land-based Exercise for Children With Post COVID-19 Condition
The latest data indicate that post COVID-19 condition is frequent in children and adolescents, with the most common symptoms being fatigue, shortness of breath, exercise intolerance and weakness.
- Conditions
- COVID-19, Children, Only, Lung Function Decreased, Quality of Life
- Trial name
- postcovidkids (NCT05216549)
- Testing
- Water-based exercise, Land-based exercise
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Józef Piłsudski University of Physical Education
Diabetic Foot
Efficacy and Safety of Heberprot-P® in Patients With Advanced Diabetic Foot Ulcer in Dasman Diabetes Institute.
The purpose of this study is to assess the efficacy and safety of the intralesional administration of Heberprot-P® (human recombinant epidermal growth factor) plus the standard treatment in patients with complex diabetic foot and…
- Trial name
- NCT03239457
- Testing
- Heberprot P
- Volunteers
- 50 people
- Sponsor
- Dasman Diabetes Institute
Respiratory-Gated Imaging Techniques
Functional Respiratory Imaging After Neostigmine or Sugammadex
The use of neuromuscular blocking agents (NMBAs) is still associated with postoperative pulmonary complications. The investigators rely on acceleromyography (AMG) of a peripheral nerve/muscle to assess the patients' breathing…
- Trial name
- FRINeoS (NCT02284412)
- Testing
- Neostigmine, Sugammadex, Water for injection
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Onze Lieve Vrouw Hospital
Necator Americanus Infection
Immunisation, Treatment and Controlled Human Hookworm Infection
24 healthy volunteers will be immunized with three times 50 L3 larvae or placebo followed by treatment with albendazol and subsequently challenged with twice 50 L3 larvae.
- Trial name
- ITCHHI (NCT03702530)
- Testing
- 3x 50 L3 larvae immunisation with albendazole treatment, 2x 50 L3 larvae infection
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pediatric Obesity
Childhood Obesity Intervention Study
Globally, childhood overweight and obesity is a public health problem. Although the rising trend in children's body mass index (BMI) has plateaued in some high-income countries, it has accelerated in low- and middle-income…
- Trial name
- NCT03665857
- Testing
- a multicomponent intervention
- Where
- China
- Volunteers
- 1,392 people
- Sponsor
- Peking University
Hookah Smoking
Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin
This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart…
- Trial name
- NCT02147665
- Testing
- Hookah smoking
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Cryotherapy Effect
Rate of Tissue Temperature Reduction Between Wetted Ice and Game Ready
This study compares the tissue temperature decrease between a wetted ice bag (ice and water) with an elastic wrap to the Game Ready® treatment.
- Trial name
- NCT04019392
- Testing
- Game Ready® device, Wetted Ice Bag with Elastic Wrap
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Arthrosis, Arthritis
The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery
The study investigates the effect of a ultrasound-guided subsartorial saphenous block on postoperative pain following major ankle and hind foot surgery.
- Trial name
- NCT02697955
- Testing
- Bupivacaine-epinephrine
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Trans Epidermal Water Loss
Effect of Twice Daily Application of Coconut Oil in Reducing Water Loss From Skin of Premature Babies in First Week of Life
The skin of newborn infants is immature and ineffective as a barrier. Preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness.
- Trial name
- TEWL (NCT01758068)
- Testing
- Coconut Oil Application
- Volunteers
- 74 people
- Sponsor
- Lady Hardinge Medical College
Exercise
Carbohydrate Feeding Frequency, Muscle Glycogen and Exercise Capacity in Runners
The aim of this study is to investigate the effects of regular sucrose feeds compared to a single large bolus given late in exercise, on muscle glycogen utilisation, exercise capacity and other markers of metabolism during running
- Trial name
- NCT03749785
- Testing
- Regular carbohydrate feeding, Single carbohydrate bolus
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Bath
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