Clinical trials: Water
Burn Surgery
The Effect of Restrictive Fluid and Vasopressin During Surgery of Burn Patients
This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the restrictive group to further evaluate significant differences in intraoperative blood loos during burn…
- Trial name
- NCT03590873
- Testing
- Vasopressin
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Hangang Sacred Heart Hospital
Healthy
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1815368 in the Blood
The main objective of this trial is to investigate the effect on the exposure of BI 1815368 in plasma when given as oral single dose together with multiple oral doses of itraconazole (Test, T) as compared to when given alone as…
- Trial name
- NCT05965583
- Testing
- BI 1815368, Itraconazole
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Malaria
Safety and Pharmacokinetics Study of DM1157 to Treat Malaria
This is a phase 1 trial to evaluate the safety and pharmacokinetics of single and multiple ascending doses and effect of food on the pharmacokinetics of a novel antimalarial drug in healthy adults.
- Trial name
- NCT03490162
- Testing
- DM1157
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Postoperative Ileus
A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus
Postoperative ileus (POI), a transient impairment of gastrointestinal (GI) motility, commonly occurs in patients who have undergone abdominal surgery and contributes to postoperative morbidity, including delayed enteral…
- Trial name
- NCT00266461
- Testing
- Daikenchuto Extract Granules (TU-100)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tsumura USA
Infected Wounds
Use of White Granulated Sugar on Wounds
How effective is sugar in reducing the debriding of sloughy, necrotic or infected exudating wounds compared with standard treatment?
- Trial name
- NCT01716273
- Testing
- Granulated Sugar, Debridement Dressing
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Moses Murandu
Bacterial Colonization
Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers
The combination of Lactitol and Probiotics (Lactobacillus acidophilus and Lactobacillus Biphidus) administered orally is an effective strategy of intestinal decolonization of Enterobacter produced OXA-48-type carbapenemase.
- Trial name
- NCT02307383
- Testing
- Lactitol, Lactobacillus
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Chronic Spontaneous Uriticaria
Interleukin-2 for Refractory Chronic Spontaneous Urticaria
The goal of this clinical trial is to learn if human interleukin-2 (IL-2) works to treat moderate to severe chronic spontaneous urticaria in adults who remain symptomatic despite oral antihistamine treatment (refractory CSU).
- Trial name
- ESIT-CSU (NCT06924762)
- Testing
- Human interleukin-2 (I) intramuscular injection
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Second Xiangya Hospital of Central South University
Leukemia, Myeloid, Chronic
Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phase
This study will evaluate the efficacy and safety of LBH589B in adult patients with chronic myeloid leukemia who are in accelerated phase or blast phase (blast crisis) with resistant disease following treatment with at least two…
- Trial name
- NCT00449761
- Testing
- LBH589
- Where
- 26 sites in United States, Germany
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Mild Cognitive Impairment
Intervention to Reduce Sedentary Time
The purpose of this study is to determine whether the researchers can help people change the amount of time they spend in sitting activities and whether this change might improve health outcomes.
- Trial name
- ReST-MCI (NCT02878486)
- Testing
- Jawbone Up, Physical Activity Education, ActivPAL
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Kansas Medical Center
Dental Caries
Effectiveness of SDF With Different Post-treatment Protocols in Arresting Dental Caries
To compare the effectiveness of the semi-annual application of 38% SDF with two post-treatment protocols in arresting dental caries in preschool children
- Trial name
- NCT05655286
- Testing
- 38% SDF treatment, not to rinse for at least 30 minutes after SDF treatment, rinse mouth immediately after SDF treatment
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy
Dietary Influence on Serotonin in Cognitive and Emotional Functioning in Women
The purpose of this study is to determine whether a chronic dose of a tryptophan-rich protein drink (lumiVida™) can improve cognitive function, emotional processing and sleep in middle-aged women.
- Trial name
- P2B_UK (NCT02172859)
- Testing
- lumiVida™
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Periodontitis, Chronic Periodontitis (Disorder)
Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Stage II Periodontitis
Gum disease (periodontitis) affects millions of people worldwide and can lead to tooth loss if untreated. The standard treatment is a deep cleaning procedure called non-surgical periodontal therapy (NSPT), where a dentist removes…
- Trial name
- aPDT-NSPT (NCT07609888)
- Testing
- Non-Surgical Periodontal Therapy (NSPT), Antimicrobial Photodynamic Therapy (aPDT) with Indocyanine Green and 810 nm Diode Laser
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Gulf Medical University
Rheumatoid Arthritis
Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4
Olokizumab (OKZ) has been shown to reverse the inhibitory effect of IL-6 on the activity of Cytochrome P450 (CYP450) isozymes CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4/5 in vitro.
- Trial name
- NCT04246762
- Testing
- Olokizumab, Omeprazole, Caffeine
- Where
- 2 sites in Bulgaria, Moldova
- Volunteers
- 17 people
- Sponsor
- R-Pharm International, LLC
Terbinafine Adverse Reaction
Clinical Effect of Caffeine Consumption in Patients Taking Oral Terbinafine
The investigators hypothesize that there would be significant changes in blood pressure or heart rate in patients consuming caffeine while taking terbinafine.
- Trial name
- NCT05667246
- Testing
- Caffeinated Coffee, Decaffeinated Coffee
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain
Misoprostol Versus Uterine Striating by Bladder Filling for Pain Relief During Office Hysteroscopy
The aim of this study is to compare the effectiveness of misoprostol versus uterine straightening by bladder filling for pain relief in menopausal patients undergoing office hysteroscopy.
- Trial name
- NCT02328495
- Testing
- Misoprostol, Bladder Filling
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Cairo University
Surgery, Cardiac Disease
Self-Affirmation for Managing Anxiety and Perceived Discomfort in Open-Heart Surgery
This study adopted a randomized controlled pretest-posttest follow-up research design. The study was conducted at a public training and research hospital (Istanbul, Turkey) specialized in thoracic and cardiovascular surgery.
- Trial name
- NCT05487430
- Testing
- Positive Self-Affirmation
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- University of Vic - Central University of Catalonia
Foot Dermatoses
Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1%
The main objective of this study is to compare subject adherence and satisfaction for two modes of treatment toenails infection (Onychomycosis) with Loceryl Nail Lacquer (Loceryl NL) and a Fungal Nail Treatment Set containing…
- Trial name
- OPEN (NCT02705664)
- Testing
- Loceryl Nail Lacquer, Urea Ointment, Bifonazole Cream
- Where
- Iceland
- Volunteers
- 22 people
- Sponsor
- Galderma R&D
Motivation
A Direct-to-Consumer Study Investigating the Effect of Specific Cannabinoid Products on Motivation, Energy Level, Focus, and Appetite in Healthy Adults
Tetrahydrocannabivarin (THCV) is a rare cannabinoid and is a homologue of THC that differs only in the length of the alkyl side chain (3C vs 5C, respectively).
- Trial name
- NCT06213064
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Phylos Bioscience, Inc.
Health Risk Behaviors
Nitrate INFORMER Water Study
Nitrate is a controversial component of vegetables, meat, and drinking water. The now well-established benefits of nitrate, through the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, on cardiovascular risk factors and…
- Trial name
- NCT05710341
- Testing
- Water with added nitrate, Water without added nitrate
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Edith Cowan University
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