Clinical trials: Zoledronic acid
IOP, Osteoporosis
Bisphosphonates for Prevention of Post-Denosumab Bone Loss
The primary goal of the study is to assess the extent to which bisphosphonate therapy will prevent decreases in bone mass that may occur after cessation of denosumab in premenopausal women with idiopathic osteoporosis (IOP)…
- Trial name
- NCT03396315
- Testing
- Alendronate, Zoledronic Acid
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Osteoporosis
Denosumab Sequential Therapy
Denosumab is a potent anti-resorptive agent and is now widely used in the treatment of osteoporosis. Although denosumab has excellent effect to increase bone mass and prevent fracture in FREEDOM study with very low complications…
- Trial name
- DST (NCT03868033)
- Testing
- Zoledronic Acid, Denosumab
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- National Taiwan University Hospital
Multiple Myeloma
Stage I Multiple Myeloma Treatment
Assessment of survival without progression of stage I MM in two groups: arm A: simple survey and arm B: administration of Zoledronate.
- Trial name
- IFM-01-04 (NCT00733538)
- Testing
- zometa
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Neovascular Age-related Macular Degeneration
Zoledronic Acid as Adjuvant Therapy in Neovascular Age-related Macular Degeneration (Z-AMD)
A pilot study of zoledronic acid as adjuvant therapy to standard anti-vascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (AMD).
- Trial name
- Z-AMD (NCT04304755)
- Testing
- Zoledronic Acid 5 MG in 5 ML Injection
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Breast Cancer
Tamoxifen Versus Anastrozole, Alone or in Combination With Zoledronic Acid
The primary objective is, first, the comparison of tamoxifen and anastrozole and, second, the comparison of zoledronate added to standard adjuvant therapy with controls according to disease-free survival (DFS) in premenopausal…
- Trial name
- NCT00295646
- Testing
- tamoxifen, anastrozole, zoledronic acid
- Where
- 72 sites in Austria, Germany
- Volunteers
- 1,803 people
- Sponsor
- Austrian Breast & Colorectal Cancer Study Group
Hip Fractures, Pneumonia
The Effect of Zoledronate on the Prevention of Pneumonia in Hip Fracture Patients
Nitrogen-containing bisphosphonates (N-BPs; such as alendronate and zoledronate) are commonly used in the treatment of osteoporosis and fracture prevention, in which zoledronate has a proven better efficacy than alendronate.
- Trial name
- Zoo-P (NCT05743179)
- Testing
- Zoledronate
- Where
- 5 sites in Hong Kong
- Volunteers
- 2,692 people
- Sponsor
- The University of Hong Kong
Hip Fractures, Osteoporosis
A Study to Improve the Collaboration Between Primary and Secondary Health Care on the Treatment of Osteoporosis After a Hip Fracture.
This is a study to improve the collaboration between primary and secondary health care on the treatment of osteoporosis after a hip fracture.
- Conditions
- Hip Fractures, Osteoporosis, Zoledronic Acid, Ambulant Nurse
- Trial name
- NCT05904353
- Testing
- Ambulant nurse-assisted administration of zoledronic acid, Usual care
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University Hospital, Akershus
Trochanteric Fracture of Femur
Trochanteric Femur Fracture Operated With Dynamic Hip Screw System (DHS) Augmented With a Biphasic Apatite Sulphate Combined With Systemic or Local Bisphosphonate
The purpose of this study is to study the process of bone regeneration around a metal device in the femoral neck canal using a synthetic bone substitute Cerament bone void filler (BVF) and bisphosphonate (Zometa) locally or…
- Trial name
- NCT04498715
- Testing
- OSTEOSYNTHESIS, Zoledronic Acid, CERAMENT BONE VOID FILLER (BVF)
- Where
- Lithuania
- Volunteers
- 20 people
- Sponsor
- Lithuanian University of Health Sciences
Imaging Examination Shows at Least One Site With Bone Metastases From Soild Tumors
A Study to Assess the Prevention of Bone-related Events in Patients With Bone Metastases From Malignant Solid Tumors Treated With JMT103 Compared to Zoledronic Acid
This is a phase Ⅲ, multicenter, randomized, double-blind, study to evaluate the efficacy and safety of JMT103 in patients with bone metastases from malignant solid tumors.
- Trial name
- NCT06221072
- Testing
- JMT103, zoledronic acid
- Volunteers
- 1,360 people
- Sponsor
- Shanghai JMT-Bio Inc.
Secondary Osteoporosis
Efficacy of Zoledronic Acid + Colaren vs Zoledronic Acid + Conventional Treatment for Osteoporosis in HIV+ and HIV- Men
Clinical trial to assess the effectiveness of the supplement Colaren® associated with zoledronic acid 4mg/annually in the treatment of osteoporosis secondary, compared to standard treatment plus zoledronic acid 4mg/annually.
- Trial name
- OSZCO (NCT03930992)
- Testing
- Colaren in HIV positive, standard treatment in HIV positive, Colaren in HIV negative
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- University of Guadalajara
Breast Cancer
Investigating the Biological Effects of the Addition of Zoledronic Acid to Pre-operative Chemotherapy in Breast Cancer
There is clear preclinical in vitro and in vivo evidence of sequence dependent synergy between chemotherapy agents and zoledronic acid.
- Trial name
- ANZAC (NCT00525759)
- Testing
- 5-FU, Epirubicin, Cyclophosphamide, Docetaxel, 5-FU, Epirubicin, Cyclophosphamide, Docetaxel, Zoledronic acid
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Triple Negative Breast Cancer
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer
Recent evidences suggest that zoledronate, one of the most used bisphosphonates (BPs) in the clinical setting for the prevention and treatment of bone metastasis in cancer patients, may have antitumor activity in early breast…
- Trial name
- YAPPETIZER (NCT03358017)
- Testing
- Zoledronate, Atorvastatin 80mg, Standard neoadjuvant cht
- Where
- 9 sites in Italy
- Volunteers
- 54 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Renal Insufficiency
Effects of Zoledronic Acid Versus Alendronate on Bone Loss After Kidney and Kidney/Pancreas Transplants
The study is designed to look at the effect of different bone treatment plans on bone loss after kidney or kidney/pancreas transplant.
- Trial name
- NCT00580047
- Testing
- Zoledronic Acid, Calcium with vitamin D, Alendronate
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Nebraska
Osteoporotic Fractures, Osteoporosis, Postmenopausal
Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II)
The goal of this study is to perform the first fracture reduction clinical trial with a potent antiresorptive agent (intravenous zoledronic acid) in the most vulnerable long-term care population.
- Trial name
- ZEST II (NCT02589600)
- Testing
- Zoledronic acid, vitamin D, calcium
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- Susan L. Greenspan
Primary Osteoarthritis
Effect of Zoledronic Acid in Primary Knee Osteoarthritis
We try to find out the effect of zoledronic acid over pain of primary knee osteoarthritis and also functional status in a period of 6 months.
- Trial name
- NCT06051344
- Testing
- Zoledronic acid
- Where
- Bangladesh
- Volunteers
- 92 people
- Sponsor
- Toufiqe-E-Ealahi
Bone Metastases
Efficacy of a Herbal Formula for Bone Metastases
RATIONALE: Nearly 50% of patients with bone metastases develop one or more complications collectively termed skeletal-related events (SREs).
- Trial name
- NCT06023420
- Testing
- 4 Herbs Formula
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer With Metastatic Bone Disease
Study Comparing Full-dose Radiotherapy Versus Reduced Dose in the Management of Bone Metastasis in Patients With Breast Cancer Receiving Zoledronic Acid
The aim of this prospective, randomized, open-label, multicentric clinical study is to assess the effícacy and tolerability of zoledronic acid 4 mg IV infused over 15 minutes every 4 weeks for a total of 6 infusions, in…
- Trial name
- NCT00172029
- Testing
- Zoledronic acid
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Novartis
Breast Cancer
Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy
The purpose of this study is to determine whether denosumab compared to placebo, will reduce the rate of first clinical fracture in women with non-metastatic breast cancer receiving (non-steroidal) aromatase inhibitor therapy.
- Trial name
- NCT00556374
- Testing
- Denosumab, Non-steroidal aromatase inhibitor therapy, Zoledronic Acid
- Where
- 46 sites in Austria, Sweden
- Volunteers
- 3,420 people
- Sponsor
- Amgen
Osteoporosis
Replication of the HORIZON Pivotal Fracture Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04736693
- Testing
- Raloxifene, Zoledronic Acid
- Where
- United States
- Volunteers
- 18,028 people
- Sponsor
- Brigham and Women's Hospital
Osteogenesis Imperfecta, Type I, Osteogenesis Imperfecta Type III
A Study in Adult Patients With Type I, III or IV Osteogenesis Imperfecta Treated With BPS804
The purpose of this study is to select a suitable dose of BPS804 by measuring the strength/quality of bone using a special type of CT scanner. Participants will be treated for 12 months and followed up for a further 12 months.
- Conditions
- Osteogenesis Imperfecta, Type I, Osteogenesis Imperfecta Type III, Osteogenesis Imperfecta Type IV
- Trial name
- Asteroid (NCT03118570)
- Testing
- setrusumab, Calcium, Vitamin D
- Where
- 25 sites in United States, Canada and 3 more
- Volunteers
- 112 people
- Sponsor
- Ultragenyx Pharmaceutical Inc