Clinical trials: adjuvant therapy, completed
Head and Neck Neoplasm
Dose-Escalated Hypofractionated Adaptive Radiotherapy for Head and Neck Cancer
Locoregional failure remains the principal mode of mortality in head and neck squamous cell carcinoma (HNSCC) treated with conventional chemoradiation therapy.
- Trial name
- DEHART (NCT04477759)
- Testing
- 50 Gy Radiation Therapy, 55 Gy Radiation Therapy, 60 Gy Radiation Therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical College of Wisconsin
Cancer of Head and Neck, Head and Neck Cancer
Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma
The goal of this trial is to test the ability of MK-3475 (pembrolizumab) to improve locoregional recurrence and distant metastatic rates in high-risk patients with locally advanced head and neck squamous cell carcinomas (HNSCCs)…
- Conditions
- Cancer of Head and Neck, Head and Neck Cancer, Neoplasms, Head and Neck, Carcinoma, Squamous Cell of Head and Neck
- Trial name
- NCT02296684
- Testing
- MK-3475 (neoadjuvant), Surgery, Intensity modulated radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- Washington University School of Medicine
Pleural Mesothelial Neoplasm
Stereotactic Body Radiation Therapy With Immunotherapy for the Treatment of Mesothelioma
This phase I trial studies the effect of stereotactic body radiation therapy and immunotherapy in treating patients with mesothelioma.
- Trial name
- NCT04926948
- Testing
- Immunotherapy, Quality-of-Life Assessment, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Melanoma Stage I, Melanoma Stage III
Adjuvant Therapy of Skin Melanoma With Alpha Interferon and Naderin
The goal of this clinical trial is to learn if adding alpha interferon to standard treatment works to prevent skin melanoma from coming back after surgery.
- Conditions
- Melanoma Stage I, Melanoma Stage III, Melanoma Stage II, Skin Melanoma
- Trial name
- ATSMAIN (NCT07671495)
- Testing
- Surgical resection, Adjuvant Radiotherapy, interferon alfa
- Volunteers
- 278 people
- Sponsor
- MIPO Clinic
Huge Hepatocellular Carcinoma (HCC) (>10cm)
The Application of Locoregional Therapy Combined With Systemic Therapy in the Perioperative Period of Huge Hepatocellular Carcinoma: A Retrospective Cohort Study
This retrospective cohort study collected data of patients with huge hepatocellular carcinoma (HCC) treated between June 1, 2018, and December 31, 2023, through the hospital information system.
- Trial name
- NCT07639294
- Testing
- hepatectomy without immune checkpoint inhibitors-based adjuvant therapy, hepatectomy with immune checkpoint inhibitors-based adjuvant therapy, neoadjuvant conversion therapy followed by surgery
- Where
- China
- Volunteers
- 715 people
- Sponsor
- Tongji Hospital
Breast Cancer
Shorter Course Radiation for the Treatment of Breast Cancer That Has Spread to Lymph Nodes
The proposed study is being done to learn more about a particular dose of radiation treatment for breast cancer that is completed in a shorter amount of time than what has traditionally been used to treat breast cancer.
- Trial name
- NCT02700386
- Testing
- Adjuvant Hypofractionated Radiation
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Pleomorphic Lobular Breast Carcinoma in Situ, Breast Florid Lobular Carcinoma in Situ
Pure Florid and Pleomorphic Lobular Carcinoma in Situ of the Breast: Towards an Increasingly Uniform Management
The goal of this retrospective multicenter observational study is to understand and evaluate the diagnostic and therapeutic management of pure forms of Florid Lobular Carcinoma In Situ (FLCIS) and Pleomorphic Lobular Carcinoma In…
- Trial name
- NCT06133465
- Testing
- Surgical wide local excision, Cavity shaving, Excision margin surgical clearance
- Where
- Italy
- Volunteers
- 1,063 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Breast Cancer, Survivorship
Culturally Aware AET Non-Initiation Intervention
The purpose of this study is to examine the feasibility and acceptability of a brief, nurse-led intervention to support breast cancer survivors who have delayed initiation of hormonal therapy or who have concerns about starting…
- Conditions
- Breast Cancer, Survivorship, Treatment Compliance, Treatment Adherence
- Trial name
- NCT05465408
- Testing
- Culturally Aware Adjuvant Endocrine Therapy (AET) Non-Initiation Intervention
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Malignant Pleural Mesothelioma
Intrapleural Photodynamic Therapy in a Multimodal Treatment for Patients With Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive tumour with poor prognosis (median survival <13 months), and high resistance to chemotherapy.
- Trial name
- MesoPDT (NCT02662504)
- Testing
- photodynamic therapy (PDT), thoracic surgery Pleurectomy / extended Decortication, Adjuvant chemotherapy
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Hypoglycemia
The Construction and Validation of a Risk Prediction Model for Perioperative Hypoglycemia in Digestive Endoscopy
Digestive endoscopic surgery, including diagnosis and treatment interventions, has become an indispensable means of managing various gastrointestinal diseases in modern gastroenterology practice.
- Trial name
- NCT07132476
- Testing
- No adjuvant therapy
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Ningbo No. 1 Hospital
Malignant Mesothelioma
Combination Chemotherapy With or Without Surgery & Chemoradiotherapy in Patients With Malignant Pleural Mesothelioma
RATIONALE: Drugs used in chemotherapy, such as methotrexate, vinorelbine, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00354393
- Testing
- Cisplatin, Methotrexate, Vinorelbine ditartrate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Gastric Cancer
Neoadjuvant Chemoradiotherapy vs. Chemotherapy Followed by Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer
Patients with histologically confirmed gastric adenocarcinoma with locally advanced gastric cancer are randomized in a 1:1 ratio to receive neoadjuvant chemoradiotherapy with DT45Gy/25f plus three cycles of XELOX therapy or…
- Trial name
- Neo-CRAG (NCT01815853)
- Testing
- Neoadjuvant Chemoradiotherapy, Neoadjuvant Chemotherapy, R0 D2 Gastrectomy
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Sun Yat-sen University
Stroke
New Tool to Enhance Post-stroke Upper Extremity Disability
Individuals with low socioeconomic status (SES) are more likely to have a stroke, more disabled at 3 months, and less likely to be independently ambulatory.
- Trial name
- NCT05277389
- Testing
- START - Startle Adjuvant Rehabilitation Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Arizona State University
Prostate Cancer
Triptorelin and Radiation Therapy in Treating Patients Who Have Undergone Surgery for Intermediate-Risk Stage III or Stage IV Prostate Cancer
RATIONALE: Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as triptorelin, may lessen the amount of androgens made by the body. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00667069
- Testing
- triptorelin, adjuvant therapy, 3-dimensional conformal radiation therapy
- Where
- 17 sites in France
- Volunteers
- 424 people
- Sponsor
- UNICANCER
Urothelial Cancer
Neoadjuvant and Adjuvant Durvalumab in Combination With Neoadjuvant Chemotherapy in Patients With Operable Urothelial Cancer.
The main objective is to demonstrate that the addition of neoadjuvant and adjuvant immunotherapy with durvalumab, to standard neoadjuvant chemotherapy (with cisplatin/gemcitabine) and surgery in urothelial carcinoma could improve…
- Trial name
- SAKK 06/17 (NCT03406650)
- Testing
- Neoadjuvant and adjuvant durvalumab
- Where
- 17 sites in Germany, Switzerland
- Volunteers
- 61 people
- Sponsor
- Swiss Cancer Institute
Unilateral Retinoblastoma
Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma
This protocol provides guidelines for the management of non-metastatic unilateral retinoblastoma and introduces an innovative adjuvant therapy for higher risk patients based upon the results of the Grupo de America Latina de…
- Trial name
- RbGALOP2 (NCT03475121)
- Testing
- Combination Chemotherapy plus Intrathecal Topotecan, Higher Dose Combination Chemotherapy plus Intrathecal Topotecan, Higher Dose Combination Chemotherapy plus Intrathecal Topotecan and Orbital Radiotherapy
- Where
- Argentina
- Volunteers
- 84 people
- Sponsor
- Hospital JP Garrahan
Colorectal Cancer, Metastatic Cancer
Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer
The purpose of this study is to find the highest dose that can be given safely to people who have had liver disease resected. This is a Phase I study.
- Trial name
- NCT00059930
- Testing
- FOLFOX regimen, dexamethasone, floxuridine
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Neoplasms, Quality of Life
Prospective, Observational, Real-world Oral Malignant Tumors Study
The aim of the study is to construct a register system of oral and maxillofacial malignant tumors based on a prospective, observational, real-world study in north Chinese population.
- Conditions
- Head and Neck Neoplasms, Quality of Life, Postoperative Complications
- Trial name
- POROMS (NCT02395367)
- Testing
- resection, adjuvant radiotherapy, neoadjuvant chemotherapy or adjuvant chemotherapy
- Where
- 7 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Head and Neck Cancer
Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00544414
- Testing
- cisplatin, docetaxel, fluorouracil
- Volunteers
- 31 people
- Sponsor
- City of Hope Medical Center
Breast Cancer, Depression
Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline
RATIONALE: Studying samples of blood in the laboratory from patients receiving tamoxifen may help doctors learn more about the effects of other drugs on the level of tamoxifen in the blood.
- Conditions
- Breast Cancer, Depression, Hot Flashes, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00667121
- Testing
- citalopram hydrobromide, escitalopram oxalate, gabapentin
- Where
- 6 sites in United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic