Clinical trials: conventional surgery, completed
Proliferative Diabetic Retinopathy
Comparison of Small-gauge Vitrectomy and Conventional Vitrectomy for Proliferative Diabetic Retinopathy
Surgical outcome of vitreous surgery for proliferative diabetic retinopathy (PDR) with conventional 20, 23, and 25-gauge vitrectomy were compared.
- Trial name
- NCT01758757
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 347 people
- Sponsor
- Kyorin University
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer
- Trial name
- NCT00003173
- Testing
- filgrastim, thiotepa, autologous bone marrow transplantation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Skin Graft, Collagen -Elastin Matrix
Efficacy of Collagen-elastin Dermal Substitute in the Treatment of Loss of Cutaneous Substances With Skin Grafts
In reconstructive surgery , most losses of cutaneous substance require the use of a thin skin graft . This technique allows epidermization of the defect by applying a thin layer of autologous epidermis.
- Trial name
- MATRIGREFFE (NCT02090361)
- Testing
- skin graft
- Where
- 4 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Rouen
Obesity, Morbid, Suture, Complication
Stapler-less Burst Pressure in a Ex-vivo Human Gastric Tissue
Stapler-less laparoscopic sleeve gastrectomy (LSG) is emerging as a new potential affordable cost-effective alternative procedure. However, no pre-clinical data are currently available on human tissue.
- Conditions
- Obesity, Morbid, Suture, Complication, Suture Rupture
- Trial name
- NCT04488042
- Testing
- Stapler-less gastrectomy, Suture
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Campania Luigi Vanvitelli
Stress Urinary Incontinence
Reducing Early Urinary Disorders After Stress Incontinence Surgery: The Role of Vaginal Wall Tension.
The progress in surgical procedures for treating female stress urinary incontinence has led to the development of tension-free techniques such as the trans-obturator tape (TOT).
- Trial name
- NCT06292702
- Testing
- Traditional Burch colposuspension, Modified Burch colposuspension
- Where
- Syria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Damascus University
Cataract, Astigmatism
Conventional Surgery vs. Verion/VerifEye
Nowadays cataract patient's expectations are closer to those of refractive surgery patients. Patients want to be spectacle independent.
- Trial name
- NCT02513745
- Testing
- Conventional, Refractive Cataract Suite (Verion + ORA)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Intubating Conditions
Propofol-sevoflurane Induction for Pediatric Nasotracheal Intubation.
Pediatric anesthesia differs significantly from adult anesthesia due to physiological differences and increased sensitivity to anesthetic agents.
- Trial name
- NCT07680400
- Testing
- reduced pharmacologic exposure, conventional anesthetic induction
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Bezmialem Vakif University
Breast Cancer
Vorinostat in Treating Women With Ductal Carcinoma in Situ of the Breast
RATIONALE: Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This clinical trial is studying how well vorinostat works in treating women with ductal carcinoma in situ…
- Trial name
- NCT00788112
- Testing
- vorinostat, protein expression analysis, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, San Francisco
Major Depression
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET
This study aims at evaluating the effect of electroconvulsive therapy in treatment-resistant depressed patients on the major serotonin degrading enzyme in the human brain using neuroimaging methods, the monoamine oxidase A.
- Trial name
- NCT02379767
- Testing
- Electroconvulsive therapy, Positron emission tomography of the brain using [11C]harmine, Structural magnetic resonance imaging
- Where
- Austria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Acute Lung Injury
A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery
The purpose of this trial is to determine whether low tidal volume during intraoperative one-lung ventilation could decrease the incidence rate of postoperative acute lung injury compared to "normal" tidal volume.
- Trial name
- NCT01194895
- Testing
- protective ventilation, conventional ventilation
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Shanghai Zhongshan Hospital
Endometrial Adenocarcinoma
V-Notes Hysterectomy in Patients With Endometrial cáncer Compared With Laparoscopic Surgery (Robotically Assisted or Not): ENOLA TRIAL
The v-NOTES surgical approach may provide important advantages over the already established effective technique (laparoscopy) for safely and successfully removing the uterus and adnexa in patients with low-grade endometrioid…
- Trial name
- ENOLA (NCT07074067)
- Testing
- Laparoscopic surgery, surgery via v-NOTES
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Breast Cancer
Epirubicin in Treating Women Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as epirubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00253500
- Testing
- pegfilgrastim, epirubicin hydrochloride, conventional surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Case Comprehensive Cancer Center
C.Surgical Procedure; Cardiac
Effects on Organ Damage and Surgical Outcome of a New Cardiopulmonary Pass System (EVADO)
The primary purpose of this study is to assess the effects of the use of EVADO with respect to a conventional cardio-pulmonary bypass (CBP) system on surgical morbidity and mortality.
- Trial name
- EVADO (NCT01805466)
- Testing
- EVADO, Conventional CPB
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele Roma
Paroxysmal Atrial Fibrillation, Indications for CABG
Botulinum Toxin Injection in Epicardial Fat Pads To Treat Atrial Fibrillation After Cardiac Surgery
The aim of this prospective randomized double-blind study was to compare the efficacy and safety of Botulinum toxin injection in epicardial fat pads for preventing recurrences (in early postoperative period) of atrial…
- Trial name
- NCT01842529
- Testing
- botulinum toxin injection, 0.9% normal saline injection, Implantable loop recorder
- Where
- 3 sites in United States, Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Alveolar Ridge Augmentation
Patient Outcomes of Staged Ridge-splitting Using Piezo-electric Surgery in Atrophic Posterior Mandible
This study aims to evaluate the clinical and radiographic outcomes of different staged ridge-splitting techniques for management of severely resorbed lower jaws in the posterior region.
- Trial name
- NCT06200077
- Testing
- Modified Ridge-Splitting
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Spinal Deformity With Sagittal Imbalance
Surgical Treatment of Spinal Deformity With Sagittal Imbalance Using Patient-specific Rods: A Multicenter, Controlled, Double- Blind Randomized Trial: The PROFILE Study
Lumbar degenerative diseases (LDD) are an increasingly common condition affecting millions of patients worldwide. LDD can impact not only function, but can also become markedly disabling and cause severe chronic pain.
- Trial name
- PROFILE (NCT02730507)
- Testing
- Surgery with patient-specific rod, Conventional straight rod
- Volunteers
- 73 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Lymphocele
Efficacy Study of Ifabond in Breast Cancer Surgery
A randomized prospective simple-blind interventional study evaluating the efficacy of the synthetic adhesive solution "Ifabond", in patients undergoing breast cancer surgery.
- Trial name
- Ifabond (NCT01742975)
- Testing
- IFABOND (TM)
- Where
- 2 sites in France
- Volunteers
- 104 people
- Sponsor
- Hôpital Européen Marseille
Ischemic Heart Disease
Automated Algorithm Detecting Physiologic Major Stenosis and Its Relationship With Post-PCI Clinical Outcomes
The presence of myocardial ischemia is the most important prognostic indicator in patients with coronary artery disease. Therefore, the purpose of percutaneous coronary intervention (PCI) is to relieve myocardial ischemia caused…
- Trial name
- Algorithm-PCI (NCT04304677)
- Testing
- Percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 486 people
- Sponsor
- Samsung Medical Center
Cataract
High-Definition 3D Visualization System for Ophthalmic Surgery
To validate a high-definition (HD) three-dimensional (3D) visualization system in cataract surgery
- Trial name
- NCT02194543
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Spinal Metastases, Bone Metastases
Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study
The purpose of the study is to investigate effectiveness of stereotactic body radiotherapy in patients with bone metastatic disease.
- Trial name
- VERTICAL (NCT02364115)
- Testing
- Stereotactic Body Radiotherapy
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- UMC Utrecht
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