Clinical trials: conventional surgery
Periapical Lesions, Chronic Apical Periodontitis of Pulpal Origin
Outcome of Bone Window Approach in Endodontic Microsurgery Using Novel Piezoelectric Device
The Bone window technique provides excellent access to the surgical site while preserving cortical bone in cases of tooth with large periapical lesion and an intact cortical plate.
- Trial name
- NCT06587048
- Testing
- periapical surgery
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Hand Injuries, Tendon Injuries
Randomized Trial of Active vs Passive Splinting for Extensor Tendon Injuries in Zones IV to VI
This study compares two methods of post-operative immobilization after surgical repair (tenorrhaphy) of extensor tendons in the fingers.
- Trial name
- NCT06950268
- Testing
- ICAMS Splinting Protocol, Classic Plaster Immobilization
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Rotator Cuff Tears
The Efficacy of Myofascial Release at the Cervicothoracic Region in Patients With Rotator Cuff Repairs
this study was conducted the patients with rotator cuff tears who underwent rotator cuff repair surger.The patients were randomly divided into 2 groups and a total of 20 subjects were randomized in a single block order using…
- Trial name
- NCT05064774
- Testing
- myofascial release technique, physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Pamukkale University
Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma
Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well erdafitinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with FGFR mutations that have spread to other places in the body and…
- Conditions
- Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma, Recurrent Childhood Malignant Germ Cell Tumor, Recurrent Childhood Medulloblastoma
- Trial name
- NCT03210714
- Testing
- Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan
- Where
- 116 sites in United States, Puerto Rico
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Stroke, Acute Ischemic Stroke
The Feasibility and Safety of RK-4 Injection Bypassing Blood-brain Barrier in the Treatment of Acute Large Hemispheric Infarction Using Intracalvariosseous Injection Device
A pilot study confirmed the feasibility and safety of neuroprotectant RK-4 intracalvariosseous(ICO) injection in patients with malignant middle cerebral artery infarction (mMCAI), showing a trend in improving 90-day functional…
- Conditions
- Stroke, Acute Ischemic Stroke, Blood-Brain Barrier
- Trial name
- SOLUTION-ICD (NCT07514949)
- Testing
- RK-4 ICO injection, Conventional treatment
- Where
- China
- Volunteers
- 6 people
- Sponsor
- yilong Wang
Trigeminal Neuralgia
Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia
The classical trigeminal neuralgia (CTN) is a common neuropathic pain in clinic by recurrent attacks of chronic sharp pain in the distribution of neuropathy branches of trigeminal neuralgia.
- Trial name
- NCT03580317
- Testing
- EA+ Carbamazepine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang Chinese Medical University
Liver Tumor
Evaluation of the Safety and Effectiveness of Pringle Method Combined With IVC Flow Limiting and Blocking Method in Laparoscopic Hepatectomy Based on Non-restrictive Fluid Therapy Strategy
The relevant data of 220 patients undergoing laparoscopic hepatectomy in our hospital were collected. Based on randomization, blindness and inclusion and exclusion criteria, the patients were divided into group A (which included…
- Trial name
- NCT06594289
- Testing
- In laparoscopic hepatectomy, the subhepatic inferior vena cava was restricted and the patient was given non-restricted intraoperative fluid intake
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Posterior Maxillary Atrophy, Maxillary Sinus Augmentation
Comparison of Three Surgical Approaches for Lateral Sinus Floor Elevation
This study compares three surgical approaches used during lateral sinus floor elevation, a procedure performed to increase bone height in the back part of the upper jaw before or together with dental implant placement.
- Trial name
- NCT07794293
- Testing
- Conventional Rotary Lateral Sinus Floor Elevation, Epinephrine-Soaked Cotton Roll, Piezoelectric Sinus Lift
- Where
- Turkey (Türkiye)
- Volunteers
- 504 people
- Sponsor
- Istanbul Aydın University
Breast Cancer
Radiofrequency Ablation in Treating Patients With Early Invasive Breast Cancer or Ductal Carcinoma in Situ
RATIONALE: Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Giving radiofrequency ablation before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be…
- Trial name
- NCT00388115
- Testing
- conventional surgery, neoadjuvant therapy, radiofrequency ablation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Bone Formation
Piezo-surgery Versus Conventional Drills
Purpose: The aim of this RCT was to evaluate and compare histomorphometric and immunohistochemical characteristics of peri-implant bone tissue after implant site preparation using piezoelectric tips versus conventional drills.
- Trial name
- NCT05753917
- Testing
- Piezo-surgery insert OR Conventional Drills
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GBR Academy
Prostate Cancer
PSMA-PET/MRI-Ultrasound Multimodal Fusion Navigation for Da Vinci Robot-Assisted Radical Prostatectomy: A Randomized Controlled Trial
Radical prostatectomy faces the core dilemma of balancing functional preservation with tumor eradication. While nerve-sparing techniques improve urinary control, intraoperative tumor localization remains imprecise, resulting in…
- Trial name
- NCT07272317
- Testing
- experimental group (navigation-assisted RARP)
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Coronary Artery Disease
Coronary Artery Bypass Grafting Strategies for the Anterolateral Territory: a Prospective Randomized Clinical Trial
The purpose of the AMI-PONT trial is to assess whether the results in term of graft patency with a novel coronary artery bypass (CABG) strategy, including a saphenous vein bridge to distribute the arterial flow of the left…
- Trial name
- AMI-PONT (NCT01585285)
- Testing
- LIMA to SVG Bridge Technique, Conventional CABG
- Where
- Canada
- Volunteers
- 208 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm
Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors
This phase I/Ib trial is to find out the best dose, possible benefits and/or side effects of BET bromodomain inhibitor ZEN-3694 (ZEN003694) when given in combination with nivolumab with or without ipilimumab in treating patients…
- Conditions
- Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Recurrent Platinum-Resistant Ovarian Carcinoma, Refractory Ovarian Carcinoma
- Trial name
- NCT04840589
- Testing
- BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure, Biospecimen Collection
- Where
- 9 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Cancer Institute (NCI)
Spinal Cord Injuries, Peripheral Nerve Injuries
Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)
The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work.
- Trial name
- NCT06672458
- Testing
- MyndMove Short Term Therapy, Conventional Short Term Therapy, MyndMove Long Term Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Cataract
Laser Treatment of the Crystalline Lens
The use of a femtosecond laser in cataract surgery that gives equivalent or improved results comapred to conventional phaco-emulsification surgery.
- Trial name
- NCT01001117
- Testing
- LensAR laser surgery, Phaco-emulsification cataract surgery
- Where
- Mexico
- Volunteers
- 75 people
- Sponsor
- LensAR Incorporated
Breast Cancer
Doxorubicin Hydrochloride, Cyclophosphamide, Docetaxel, and S-1 Before Surgery in Treating Women With Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, docetaxel, and S-1, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Trial name
- NCT00994968
- Testing
- cyclophosphamide, docetaxel, doxorubicin hydrochloride
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Yonsei University
Femoro Acetabular Impingement
The Innovation of 3D Printing for Preoperative Planning in Hip Preservation Surgery
This is a randomized controlled trial (RCT) to evaluate the introduction of a 3D printed model into the pre and intra-operative planning for arthroscopic femoroacetabular impingement (FAI) surgery.
- Trial name
- NCT04505020
- Testing
- 3D Print + Conventional imaging, Conventional imaging
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Nova Scotia Health Authority
Periodontitis
Supplementation With L-ornithine But Not L-arginine Increases Density of CD68+ and CD163+ Macrophages in Periodontitis
The aim of the study was to investigate whether oral administration of L-arginine or L-ornithine could modulate local representation density and ratio of macrophages in periodontitis-affected gingiva by using immunohistochemical…
- Trial name
- NCT05042024
- Testing
- Scaling and root planing, Oral L-arginine aspartate administration, Oral L-ornithine aspartate administration
- Where
- Ukraine
- Volunteers
- 75 people
- Sponsor
- Ukrainian Medical Stomatological Academy
Periodontal Pocket, Tooth,Non Vital
Chlorhexidine Intracanal Medicament in Periodontal Healing in Concomitant Endo Perio Lesion With Communication
The aim of this prospective randomized controlled clinical trial is to evaluate the effectiveness of chlorhexidine intracanal medicament along with periodontal treatment in concomitant endodontic periodontal lesions with…
- Trial name
- NCT02627326
- Testing
- open flap debridement
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Cerebral Palsy, Spasticity
Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy
The aim of our work is to investigate whether electrical Lateral Cord Stimulation (LCS) causes an inhibitory and modulatory action by indirect cerebellar activation, so releasing spasticity and the spastic syndrome in selected…
- Trial name
- Andreani1 (NCT02199015)
- Testing
- Lateral spinal cord surgical implant of electrodes
- Where
- 2 sites in Argentina, Germany
- Volunteers
- 40 people
- Sponsor
- Juan Carlos M. Andreani MD