Clinical trials: flow cytometry
Lymphoma, Hemophagocytic Lymphohistiocytoses
Flow Cytometry for the Study of T-Cell Populations in Hemophagocytic Lymphohistiocytosis Associated With Lymphomas
The goal of this study is to explore the associations between T cell activation and the occurrence of hemophagocytic lymphohistiocytosis (HLH) in patients with newly diagnosed lymphomas.
- Trial name
- LA-HLH (NCT06585124)
- Testing
- Flow Cytometry
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Membranous Nephropathy
Effect of B-cell Depleting Therapies on PLA2R-specific B Cells in Patients With Membranous Nephropathy
This is a non-pharmacological interventional monocentric study to primarily assess the levels of circulating phospholipase A2 receptor (PLA2R)-specific B cells in patients with PLA2R-mediated MN enrolled in the ORION and MONET…
- Trial name
- DEEPER (NCT06994468)
- Testing
- Flow-cytometry tetramer-based antigen-bait assay
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Acute Lymphoblastic Leukemia, Thrombosis
Coagulopathy in Childhood Acute Lymphoblastic Leukaemia
The goal of this study is to investigate the hemostatic balance in children with acute lymphoblastic leukaemia (ALL) treated according to the ALLTogether1 protocol with focus on the early treatment period including concomitant…
- Conditions
- Acute Lymphoblastic Leukemia, Thrombosis, Bleeding, Hemostatic Disorder
- Trial name
- CoagCALL (NCT06242353)
- Testing
- Coagulopathy parameters
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Immune Thrombocytopenia, Thrombocytopathy
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.
- Conditions
- Immune Thrombocytopenia, Thrombocytopathy, Acute Leukemia, Hemorrhagic Disorders
- Trial name
- NCT05654766
- Testing
- Flow cytometry, Platelet aggregation and plasma coagulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Breast Cancer
Immune Response in Patients Who Have Undergone Vaccine Therapy for Stage III or Stage IV Breast Cancer That Overexpresses HER2
RATIONALE: Studying the immune response to a vaccine made from HER2/neu protein may help doctors plan better treatment for patients with breast cancer that overexpresses HER2.
- Trial name
- NCT00363012
- Testing
- HER-2/neu intracellular domain protein, flow cytometry, immunohistochemistry staining method
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Washington
Myocardial Infarction
Platelet Leukocyte Aggregates in Acute Cardiac Syndrome vs Healthy Volunteers
This project aims to refine previous studies including the investigators work recently published in August 2012 Journal Thrombosis and Thrombolysis.
- Trial name
- NCT01797016
- Where
- Israel
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Multiple Sclerosis
STAT4 in Multiple Sclerosis by PCR and Flow Cytometry
1. To determine the level of STAT4 expression in different cases of multiple sclerosis and its relation to disease severity . 2. compare the sensitivity and specificity of STAT4 levels using both PCR and flow cytometry.
- Trial name
- NCT03893344
- Testing
- detection of STAT4 gene
- Where
- Egypt
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post Operative Pain, Opioid Use, Unspecified
Sensory Outcomes in Active Substance Users
The incidence and severity of postoperative pain after spine surgery are notably high, often requiring intensive management and potentially affecting the patient's recovery, satisfaction, and long-term outcomes.
- Trial name
- NCT06639438
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Bortezomib and Topotecan in Treating Patients With Advanced Solid Tumors
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- NCT00388089
- Testing
- bortezomib, topotecan hydrochloride, flow cytometry
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Davis
Giant Cell Arteritis, Polymyalgia Rheumatica
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR).
- Trial name
- GCAIO (NCT06460142)
- Testing
- Aortic/ cardiac magnetic resonance imaging, Vascular ultrasound, Transorbital Ultrasound
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Cardiac Surgery for Bypass Grafting
Pilot Study to Establish a Repertoire of Megakaryocyte Markers, Quantifiable by Spectral Flow Cytometry, in Bone Marrow and Circulating in Patients Undergoing Cardiac Surgery for Bypass Grafting
Megakaryopoiesis, the mechanism of blood platelet production, is difficult to assess in clinical practice as it relies solely on microscopic description.
- Trial name
- EPIMéCA (NCT07026851)
- Testing
- Blood and bone marrow sampling
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Acute Myeloid Leukemia, Myelodysplastic Syndromes
IFN-α in Relapse Prevention.
To investigate the efficacy of interferon-α prophylaxis in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with TP53 mutation who were negative for minimal residual disease (MRD) by flow cytometry…
- Trial name
- NCT07449286
- Testing
- IFN-α
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Cold Atmospheric Plasma (CAP), J-Plasma
Effects of Cold Atmospheric Plasma (CAP) on Peritoneal Tumor Tissue
There are to date no studies available that have examined the effects of CAP on tumor tissue in patients. The aim of this study is to investigate these effects in patients undergoing surgery for peritoneal metastases.
- Conditions
- Cold Atmospheric Plasma (CAP), J-Plasma, Peritoneal Tumor
- Trial name
- NCT06796634
- Testing
- J-plasma
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Brain and Central Nervous System Tumors
Study of Tissue and Blood Samples From Patients With High-Grade Glioma
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01004887
- Testing
- diagnostic laboratory biomarker analysis
- Where
- 110 sites in United States
- Volunteers
- 631 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Rheumatoid Arthritis
Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis
To evaluate the changes in the frequencies of circulating CD4+ and CD4- T cells expressing CD8αα and CD8αβ in peripheral blood of RA patients in comparison with healthy controls.
- Trial name
- NCT05827562
- Testing
- flow cytometry
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis
Flow Cytometry Analysis of the Reactive Oxygen Species in Immature Granulocytes in Septic Patient
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Early during sepsis course, immature neutrophils could be found in the bloodstream and may be less efficient than mature…
- Trial name
- SEPSIROS (NCT03846596)
- Testing
- Additional blood tube
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Limoges
Peanut Allergies
Flow CAST® Peanut Trial
This will be a multi-center, prospective evaluation, conducted at a minimum of four (4) U.S. sites. Sites will enroll peanut allergic subjects, subjects with allergies other than peanut and apparently healthy non-atopic control…
- Trial name
- NCT07775430
- Testing
- Basophil activation test
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Bühlmann Laboratories AG
Diminished Ovarian Reserve (DOR)
Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Diminished Ovarian Reserve
A multi-center, prospective, randomised controlled clinical trial (1:1 treatment ratio), designed to investigate the efficacy and safety of autologous SVF in improving the pregnancy outcome of infertile patients with DOR.
- Trial name
- aSVF-DOR (NCT07901218)
- Testing
- Lower abdominal liposuction and preparation of SVF, Ovarian injection, Conventional ART treatment
- Where
- 4 sites in China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital
Cutaneous T-cell Lymphoma Stage I, Cutaneous T-cell Lymphoma Stage II
Vorinostat in Patients With Primary Cutaneous T-Cell Lymphoma
This phase II trial studies the side effects and how well vorinostat works in treating patients with primary cutaneous T-cell lymphoma.
- Conditions
- Cutaneous T-cell Lymphoma Stage I, Cutaneous T-cell Lymphoma Stage II, Cutaneous T-cell Lymphoma Stage III, Cutaneous T-cell Lymphoma Stage IV
- Trial name
- NCT00958074
- Testing
- vorinostat, flow cytometry, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Prosthesis-Related Infections, Arthroplasty, Replacement, Hip
Exploring Novel Diagnostic Tools for Periprosthetic Joint Infection
Joint replacement is a valuable surgical intervention that improves quality of life, provides pain relief, and restores function of patients.
- Conditions
- Prosthesis-Related Infections, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- VECTOR-PJI (NCT05582460)
- Testing
- Reporter Gene Assay, Flow Cytometry
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital