Clinical trials: flow cytometry
Benign Prostatic Hyperplasia, Prostate Carcinoma
Human Prostate Tissue Model to Maintain and Study Prostate Cancer Stem Cells
This pilot research trial studies the use of a human prostate tissue model to maintain and study prostate cancer stem cells. A human prostate tissue model uses leftover tissue that was removed during surgery from patients with…
- Trial name
- NCT02425800
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Wake Forest University Health Sciences
Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML)
Single Agent JNJ-56022473 in MDS and AML Patients FAILING HYPOMETHYLATING AGENT BASED THERAPY
The outcome of HMA-refractory patients with MDS or AML is dismal with a median survival of 5 months after failure, representing a significant unmet medical need due to the very limited treatment options.
- Trial name
- SAMBA (NCT02992860)
- Testing
- JNJ-56022473, Bone marrow analyses and CBC with differential, Flow cytometry analyses
- Where
- 10 sites in France, Germany
- Volunteers
- 25 people
- Sponsor
- GWT-TUD GmbH
Astrocytoma, Glioma
Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors
This research trial studies qualitative, qualitative, and functional studies over the first year in measuring immune system response in patients with brain tumors.
- Conditions
- Astrocytoma, Glioma, Oligodendroglioma
- Trial name
- NCT02747407
- Testing
- Hepatitis A Vaccine, Laboratory Biomarker Analysis, Tetanus Toxoid Vaccine
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University Health Sciences
Leukemia
Comparison of Laboratory Test Results of Minimal-Residual Disease in Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Diagnostic procedures that find residual disease may help predict if the disease will come back in patients diagnosed with acute myeloid leukemia.
- Trial name
- NCT01498302
- Testing
- diagnostic laboratory biomarker analysis, flow cytometry
- Volunteers
- 10 people
- Sponsor
- Children's Oncology Group
Weight Loss, Exercise
Effects of Exercise and Short Term Rapid Weight Loss on Whole Blood Cells and Lymphocyte Subsets in Highly Trained National Level Wrestlers
Wrestling is a weight-classified sport in which athletes frequently apply rapid weight loss (RWL) strategies prior to competition.
- Trial name
- EX-RWL-Lymphoc (NCT07567937)
- Testing
- Exercise, Rapid Weight Loss
- Where
- Turkey (Türkiye)
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Drug-Induced Liver Injury
Immune Responses in Hepatocellular Carcinoma Patients After Treatment With Direct Acting Antiviral Drugs
Case control Study to assess the difference of immune cell responses between patients with chronic HCV- related liver cirrhosis who develop HCC after treatment with DAAs and those who do not develop HCC
- Trial name
- NCT03602703
- Testing
- Flow cytometry and Western Blot analysis
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
Multiple Myeloma and Plasma Cell Neoplasm
Lenalidomide and Rituximab in Treating Patients With Recurrent and/or Refractory Multiple Myeloma
RATIONALE: Lenalidomide may stop the growth of multiple myeloma by blocking blood flow to the cancer. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways.
- Trial name
- NCT00567229
- Testing
- rituximab, lenalidomide, microarray analysis
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ischemic Stroke
Inflammatory faCtors AfteR acUte Ischemic Stroke
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke.
- Trial name
- ICARUS (NCT04412187)
- Testing
- [18F]-GE-180 PET, 3T MRI, immune cell profiling in blood
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Martin Dichgans
Acute T-Cell Leukemia-Lymphoma
Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma
This study will examine the safety and effectiveness of Alemtuzumab (Campath-1H) for treating patients with adult T-cell leukemia/lymphoma (ATL).
- Trial name
- NCT00061048
- Testing
- Alemtuzumab
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Recurrent Melanoma, Stage IV Melanoma
Individualized Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery
This clinical trial studies individualized temozolomide (TMZ) in treating patients with stage IV melanoma that cannot be removed by surgery.
- Trial name
- NCT01328535
- Testing
- temozolomide, flow cytometry, staining method
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Healthy Volunteers
Analyzes of Nasal Tissue-resident Memory Immune Cells and Peripheral Memory Cells Able to Migrate to Airway Tissues (MUCOVAC)
Clinical evaluation of vaccines against respiratory viruses is currently based on the analysis of systemic immune responses, whereas respiratory immunity is the first line of defense against respiratory pathogens.
- Trial name
- MUCOVAC (NCT06469359)
- Testing
- Nasal tissue-resident memory T and B cells, Nasal fluid sampling, Saliva sampling
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiotoxicity, Cardiovascular Disease
Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses
The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.
- Conditions
- Cardiotoxicity, Cardiovascular Disease, Neurovascular Disorder, Endothelial Disfunction
- Trial name
- NCT04568161
- Testing
- Physical Characteristics, Muscular Sympathetic Nervous Activity, Cardiac Function
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Colorectal Cancer
Intraoperative Flow Cytometry In Colorectal Cancer
This study was designed to investigate the efficacy of flow cytometry to accurately identify between normal and cancer cells in colon epithelium in humans diagnosed with colorectal cancer.
- Trial name
- NCT05261542
- Testing
- flow cytometry
- Where
- Greece
- Volunteers
- 106 people
- Sponsor
- University Hospital, Ioannina
Head and Neck Cancer (H&N), Trauma Sequelae
Immunomonitoring of Circulating Immune Cells in Maxillofacial Surgery
The immune response following facial reconstruction may help predict healing time and the date of discharge after maxillofacial surgery.
- Conditions
- Head and Neck Cancer (H&N), Trauma Sequelae, Osteoradionecrosis of Jaws
- Trial name
- IMMUNOFACE (NCT07772063)
- Testing
- Treg
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lymphoblastic Leukemia (ALL)
Potential Role of CD9 and Implication of Motility Process in Pathogenesis of TEL/ALM1-positive ALL Relapses (LAL TEL/ALM1 and CD9).
Down regulation of CD9 in TEL/AML1-positive ALL is addressed in motility assays to explore its role in B-ALL pathogenesis and its potential implication in relapses (and prognosis).
- Trial name
- LAL TEL/ALM1 (NCT01282593)
- Testing
- Impact of CD9 expression level on motility assays, Post-transcriptional regulation of CD9
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Rennes University Hospital
Covid19, Acute Respiratory Distress Syndrome
Clinical Features of COVID-19 Patients
The data were retrospectively collected during the first and the second wave of epidemic in COVID-19 patients with Severe Acute Respiratory Syndrome Coronavirus 2, at the moment of intensive care unit admission and during the in…
- Conditions
- Covid19, Acute Respiratory Distress Syndrome, Ventilatory Failure
- Trial name
- NCT04815304
- Testing
- peripheral lymphocytes subsets
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- San Salvatore Hospital of L'Aquila
HIV Infections, HIV Seronegativity
A Blood Test to Look at Cells of the Immune System in Healthy Children
The purpose of this study is to learn more about some of the immune cells in the blood (CD4 cells, for example) of healthy children in order to better understand the differences in the blood cells of children infected with HIV.
- Trial name
- NCT00001109
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Systemic Lupus Erythematosus
Expression of CXCR4 in Patients With Systemic Lupus Erythematosus
The objective of this study is to estimate the possible role of CD184 in the pathogenesis of SLE; comparing its level among SLE cases to healthy controls.
- Trial name
- NCT04799730
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Platelet Aggregation
Measurement of Platelet Dense Granule Release in Healthy Volunteers
Aspirin has been shown to reduce cardiovascular events in at risk individuals. Elucidation of mechanisms of aspirin resistance and a possible loss of effect of aspirin over time with chronic aspirin treatment necessitate a more…
- Trial name
- NCT00942617
- Testing
- Aspirin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Brain and Central Nervous System Tumors
Bevacizumab and Sorafenib in Treating Patients With Recurrent Glioblastoma Multiforme
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00621686
- Testing
- bevacizumab, sorafenib tosylate
- Where
- 204 sites in United States
- Volunteers
- 54 people
- Sponsor
- Alliance for Clinical Trials in Oncology