Clinical trials: flow cytometry, completed
Neoplastic Cells, Circulating
The Detection of Circulating Tumor Cells (CTCs) in Patients With Colorectal Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment
Circulating tumor cells (CTCs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. Enumeration and molecular characterization of CTCs in colorectal cancer could play an important role in…
- Trial name
- NCT02450422
- Testing
- Flow cytometry (FCM), RT-PCR
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Leukemia
Prognostic Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood or tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01245231
- Testing
- protein expression analysis, western blotting, flow cytometry
- Volunteers
- 150 people
- Sponsor
- Children's Oncology Group
Melanoma Stage I, Melanoma Stage III
Adjuvant Therapy of Skin Melanoma With Alpha Interferon and Naderin
The goal of this clinical trial is to learn if adding alpha interferon to standard treatment works to prevent skin melanoma from coming back after surgery.
- Conditions
- Melanoma Stage I, Melanoma Stage III, Melanoma Stage II, Skin Melanoma
- Trial name
- ATSMAIN (NCT07671495)
- Testing
- Surgical resection, Adjuvant Radiotherapy, interferon alfa
- Volunteers
- 278 people
- Sponsor
- MIPO Clinic
Head and Neck Cancer
Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
RATIONALE: Studying gene mutations in samples of DNA from patients with head and neck cancer and a family history of cancer may help doctors learn more about the development of cancer in families.
- Trial name
- NCT00482872
- Testing
- gene expression analysis, mutation analysis, polymerase chain reaction
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Carotid Atherosclerosis
Individualized Physical Activity and Carotid Plaque Instability
Intraplaque hemorrhage (IPH) is one of the main features of the carotid plaque instability's and predictor of ischemic stroke. Benefits (on the basis on benefit/risk ratio) of the carotid endarterectomy remain unclear for stroke…
- Trial name
- PACAPh (NCT04053166)
- Testing
- individualized home-based physical activity, MRI, blood sampling
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Lung Cancer, Surgery
Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.
Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality.
- Trial name
- POIR (NCT03549546)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Neoplastic Cells, Circulating
The Detection of Circulating Tumor Cells (CTCs) in Patients With Breast Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment
Circulating tumor cells (CTCs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. Enumeration and molecular characterization of CTCs in breast cancer could play an important role in…
- Trial name
- NCT02450357
- Testing
- Flow cytometry (FCM), RT-PCR
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Chronic Lymphocytic Leukemia
Personalized Multi-peptide Vaccination in CLL Patients
The aim of this study is to evaluate the efficiency along with safety and toxicity of a personalizied multi-peptide vaccine in combination with the TLR1/2 ligand XS15 in CLL patients undergoing ibrutinib-based regimes.
- Trial name
- NCT04688385
- Testing
- Multipeptide Vaccine+ XS15
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Miscarriage
Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified.
- Trial name
- NCT04492098
- Testing
- MAIT cells
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Leukemia, Lymphoma
Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer
RATIONALE: Pentostatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cyclophosphamide and mitoxantrone, work in different ways to stop the growth…
- Trial name
- NCT00546377
- Testing
- filgrastim, pegfilgrastim, rituximab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Coronary Syndrome
Pericoronary Fat Attenuation Index and High-risk Plaque in Patients With Acute Coronary Syndrome
This study aimed to investigate the relationship between CCTA-based pericoronary inflammation and plaque features as well as local immune-inflammatory biomarkers in ACS patients.
- Trial name
- NCT04792047
- Testing
- HRP frequency, plaque compostion and local immune-inflammatory activation
- Where
- China
- Volunteers
- 130 people
- Sponsor
- RenJi Hospital
Lymphoma
Veltuzumab and Milatuzumab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
A phase I dose escalation study of veltuzumab and milatuzumab in relapsed and refractory B-cell NHL. The phase I study will be followed by a pilot phase II study.
- Trial name
- NCT00989586
- Testing
- milatuzumab, veltuzumab, Correlative/Special Studies
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Beth Christian
Ganglioneuroblastoma, Localized Resectable Neuroblastoma
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma.
- Conditions
- Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma
- Trial name
- NCT00904241
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 259 sites in United States, Australia and 6 more
- Volunteers
- 10,000 people
- Sponsor
- Children's Oncology Group
Health Care Worker Patient Transmission, Receptor Site Alteration
Different Susceptibility to SARS CoV-2 Infection Among Health Care Workers Highly Exposed to COVID-19.
The primary objective of this study is to establish differences in susceptibility to SARS CoV-2 infection among health care workers (HCW) highly exposed to patients with COVID-19 diagnosis.
- Conditions
- Health Care Worker Patient Transmission, Receptor Site Alteration, Susceptibility, Disease, Immune Response
- Trial name
- CoVEX (NCT04402827)
- Testing
- Susceptibility to infection
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
Colorectal Cancer
T Helper Cytokines in End Stage Colorectal Cancers
Colorectal cancers are the third most common type of cancer in the world. Peritoneal carcinomatosis and intraabdominal acid development occur in advanced stages of colorectal cancers.
- Trial name
- NCT04540146
- Testing
- Flow-Cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Training and Research Hospital
Infertility, Female
Infections and Unexplained Infertility
1. Background: In women, unexplained infertility has been associated with a range of cellular and molecular defects in the endometrium, adverse immune responses and immunological factors.
- Trial name
- NCT03581617
- Testing
- NK cell analysis, Herpesvirus detection, sHLA-G analysis
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Leukemia
Gene Expression in Tissue From Patients With Acute Lymphoblastic Leukemia
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00898261
- Testing
- microarray analysis, reverse transcriptase-polymerase chain reaction, flow cytometry
- Volunteers
- 137 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Leukemia
Panobinostat (LBH589) and Imatinib Mesylate in Treating Patients With Previously Treated Chronic Phase Chronic Myelogenous Leukemia
RATIONALE: Panobinostat and imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00686218
- Testing
- imatinib mesylate, panobinostat, polymerase chain reaction
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- City of Hope Medical Center
Kidney Transplant
Dosing Regimen of Eculizumab Added to Conventional Treatment in Positive Cross Match Living Donor Kidney Transplant
A strongly positive crossmatch has long been considered an absolute contraindication to kidney transplantation and most patients with anti-human leukocyte antigen (HLA) antibody never were able to receive a kidney transplant.
- Trial name
- NCT00670774
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mark Stegall
Leukemia
Studying Biomarkers in Cell Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01057290
- Testing
- gene expression analysis, protein expression analysis, fluorescence activated cell sorting
- Volunteers
- 75 people
- Sponsor
- Children's Oncology Group