Clinical trials: flow cytometry
Spinal Cord Injury, Acute
The Neuroinflammatory Response and Biomarkers in Acute Traumatic Spinal Cord Injury
The study is a prospective cohort study designed to assess the diagnostic and prognostic potential of biomarker measurement in acute traumatic spinal cord injury (TSCI), and to examine the neuroinflammatory response to acute TSCI.
- Trial name
- NCT03505463
- Testing
- Blood samples, Cerebrospinal fluid sample, Clinical examination
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Sepsis, Immunologic Paralysis
Immune Homeostasis in Sepsis and Septic Shock
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
- Conditions
- Sepsis, Immunologic Paralysis, Immunologic Suppression, Immune Deficiency
- Trial name
- IMHOTEP (NCT04448951)
- Testing
- transcriptomics, flow-cytometry, cytokines
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Systemic Mastocytosis
Diagnostic Value of Bone Marrow Tryptase in Systemic Mastocytosis
The hypothesis of the study is that Bone Marrow Tryptase (MT) level is a diagnostic marker of Systemic Mastocytosis (SM). Determination of the bone marrow tryptase in Bone Marrow Aspirate (BMA) could be a new diagnostic criteria…
- Trial name
- EvaTryMS (NCT02441166)
- Testing
- Mastocytosis diagnosis
- Where
- 8 sites in France, Martinique
- Volunteers
- 250 people
- Sponsor
- University Hospital, Toulouse
Allergy
Study if the Presence of Functional FcERI/RII on the Surface of Human Blood Platelet
Anaphylactic shock is the most severe expression of immediate hypersensitivity reactions. The mechanisms leading to these reactions are still poorly understood and may involve platelets, especially in the most severe forms.
- Trial name
- FERIplaq (NCT05848986)
- Testing
- Flow cytometry
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Drug-Induced Liver Injury
Immune Responses in Hepatocellular Carcinoma Patients After Treatment With Direct Acting Antiviral Drugs
Case control Study to assess the difference of immune cell responses between patients with chronic HCV- related liver cirrhosis who develop HCC after treatment with DAAs and those who do not develop HCC
- Trial name
- NCT03602703
- Testing
- Flow cytometry and Western Blot analysis
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
Coronavirus Disease 2019 (COVID-19)
Study Evaluating the Safety and Efficacy of Autologous Non-Hematopoietic Peripheral Blood Stem Cells in COVID-19
SENTAD-COVID Study is an adaptive, prospective, multicentric, open-label, and randomized controlled clinical trial involving hospitalized adult patients with confirmed coronavirus disease 2019 (COVID-19) infection during the…
- Trial name
- SENTAD-COVID (NCT04473170)
- Testing
- Autologous Non-Hematopoietic Peripheral Blood Stem Cells (NHPBSC), COVID-19 standard care
- Where
- United Arab Emirates
- Volunteers
- 146 people
- Sponsor
- Abu Dhabi Stem Cells Center
Cutaneous T-Cell Lymphoma
Novel Flow-cytometry Approaches to Improve the Detection of Tumor Cells in CTCL
Identification and quantitation of circulating tumor cells in patients with cutaneous T-cell lymphoma -mycosis fungoides (MF)/Sézary syndrome (SS)- are required for diagnosis and precising the actual staging and response to…
- Trial name
- NCT06382844
- Testing
- Detection and quantitation of (blood) tumor cells in patients with mycosis fungoides (MF) / Sézary syndrome (SS).
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Glomerulonephritis Acute
Urinary T Lymphocytes Predict Renal Flares in Patients With Inactive ANCA-associated Glomerulonephritis
Urinary CD4+ and CD8+ T lymphocytes may predict renal flares in patients with inactive ANCA-associated vasculitis and thus serve as early non-invasive biomarkers.
- Trial name
- PRE-FLARED (NCT04428398)
- Testing
- Analysis of urine samples with flow cytometry
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Pancreas Cancer
Perioperative Immune Function and Clinical Complications in Pancreaduodenectomy
Perioperative immunologic signatures can predict the risk of postoperative complications. The results will be puplished as two smanuscripts.
- Trial name
- NCT04774198
- Testing
- blood sample
- Where
- Denmark
- Volunteers
- 58 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Multiple Myeloma
Study of Initial Treatment With Elotuzumab, Carfilzomib, Lenalidomide and Dexamethasone in Multiple Myeloma
This study was a multi-center, open-label, single-arm, Phase 2 study where newly diagnosed Multiple Myeloma requiring systemic chemotherapy will be eligible for enrollment. A total of 46 subjects were enrolled.
- Trial name
- NCT02969837
- Testing
- Elotuzumab, Carfilzomib, Lenalidomide
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Chicago
Leukemia, Chronic Lymphatic
iVAC-CLL01: Patient-individualized Peptide Vaccination After First Line Therapy of CLL
The aim of this study is to induce a peptide-specific immune response in CLL patients by multi-peptide vaccination with a patient-individualized peptide cocktail.
- Trial name
- NCT02802943
- Testing
- Peptide Vaccine, Imiquimod
- Where
- 5 sites in Germany
- Volunteers
- 56 people
- Sponsor
- University Hospital Tuebingen
Anaplastic Large Cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma
Fusion Protein Cytokine Therapy After Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma
RATIONALE: Biological therapies, such as fusion protein cytokine therapy, may stimulate the immune system in different ways and stop cancer cells from growing.
- Conditions
- Anaplastic Large Cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Intraocular Lymphoma
- Trial name
- NCT00720135
- Testing
- DI-Leu16-IL2 immunocytokine, rituximab, flow cytometry
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- City of Hope Medical Center
Lupus Nephritis
Urinary T Cell Biomarker for Prediction in Lupus Nephritis
Urinary T-lymphocytes may be predictive for clinical outcome in patients with lupus nephritis. The investigators hypothesize that the amount of CD4+ effector/memory T-cells in urine at time of diagnosis predicts the outcome of…
- Trial name
- NCT04320797
- Testing
- Flow cytometry analysis of urine samples
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 79 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Myeloma (MM)
MMulti-Immune HR; Multi-Target Immunotherapy for High-Risk Multiple Myeloma
The purpose of this research is to learn whether using teclistamab and talquetamab at different time points will improve survival in participants with high-risk Multiple Myeloma (MM).
- Trial name
- NCT07029776
- Testing
- teclistamab+daratumumab followed by talquetamab+daratumumab followed by duration treatment with daratumumab and lenalidomide extended/maintenance, melphalan (MEL)-based hematopietic stem cell transplantation (HSCT) followed by drug therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Prostate Cancer
White Button Mushroom Extract in Treating Patients With Recurrent Prostate Cancer After Local Therapy
RATIONALE: White button mushroom extract may stop or delay the development of recurrent prostate cancer. PURPOSE: This phase I trial is studying the side effects and best dose of white button mushroom extract in treating patients…
- Trial name
- NCT00779168
- Testing
- white button mushroom extract, flow cytometry, immunologic technique
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- City of Hope Medical Center
Hashimoto's Thyroiditis
Role of Follicular T Cells in Hashimoto's Thyroiditis
Measure the frequency of Follicular helper Tcells and Follicular regulatory T cells in peripheral blood samples in Hashimoto's pts in comparison with control.
- Trial name
- NCT06521359
- Testing
- flow cytometry
- Volunteers
- 90 people
- Sponsor
- Omnia Ahmed Nafea Mohamed
ARDS, Platelet Abnormality
PLAIAR-Trial: Platelets in Inflammation and Resolution
Detection and determination of platelets in bronchoalveolar lavage fluid and blood in ARDS and non-ARDS-patients. Correlation with phenotype and inflammation parameters in blood and outcome parameters.
- Trial name
- PLAIAR (NCT05098106)
- Testing
- Bronchoscopy, blood sampling; testing.
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital Muenster
Neuroblastoma
Biomarkers in Samples From Young Patients With Neuroblastoma
RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01358604
- Testing
- polymerase chain reaction, protein expression analysis, western blotting
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
CD55 - Cluster of Differentiation Antigen 55 Deficiency, Primary Intestinal Lymphangiectasis
Transcriptome and Metabolic Analyses of CHAPLE Disease
CHAPLE syndrome (complement hyperactivation, angiopathic thrombosis, protein losing enteropathy) is a newly discovered genetic disorder, which is caused by deleterious mutations in the CD55 gene.
- Conditions
- CD55 - Cluster of Differentiation Antigen 55 Deficiency, Primary Intestinal Lymphangiectasis, Protein-Losing Enteropathies, Complement Regulatory Factor Defect
- Trial name
- CHAPLEOMIC (NCT03950804)
- Testing
- Eculizumab Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Visceral Leishmaniasis
Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of Cure
Left untreated, visceral leishmaniasis (VL) is fatal. The highest burden of VL worldwide is in eastern Africa where field-adapted diagnostic and test-of-cure tools and treatment are lacking.
- Trial name
- VL-ToC (NCT05426577)
- Testing
- ELISA, LAMP, Cytokine Release Assay
- Where
- Ethiopia
- Volunteers
- 60 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland