Clinical trials: ifosfamide
Extranodal NK-T-Cell Lymphoma
VP-16, Ifosfamide, Dexamethasone, L-asparaginase Chemotherapy in Patients With Extranodal Natural Killer T Cell Lymphoma (VIDL+ASCT)
Open-labeled, multicenter phase II study of VIDL (VP-16, Ifosfamide, Dexamethasone, L-asparaginase) chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation in patients with stage III/IV extranodal…
- Trial name
- VIDL+ASCT (NCT02544425)
- Testing
- Etoposide, Ifosfamide, Dexamethasone
- Where
- 2 sites in South Korea
- Volunteers
- 27 people
- Sponsor
- Samsung Medical Center
Osteosarcoma, Localised High Grade Osteosarcoma of the Limbs
Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children
The purpose of this study is to compare two preoperative chemotherapy regimens based on high-dose methotrexate courses given alternately either with doxorubicin or with etoposide-ifosfamide.
- Trial name
- NCT00180908
- Testing
- Etoposide, Ifosfamide, Methotrexate, Doxorubicin, Methotrexate
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults
Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy
This is a randomized Phase III clinical trial in the setting of localized high-risk soft tissue sarcomas (STS). This study will compare a standard neoadjuvant chemotherapy with epirubicin plus ifosfamide versus a histology-driven…
- Trial name
- NCT01710176
- Testing
- epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3), gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8), trabectedin 1.3 mg/m2
- Where
- 15 sites in Italy, Spain
- Volunteers
- 550 people
- Sponsor
- Italian Sarcoma Group
Sarcoma, Soft Tissue
Ifosfamide, Doxorubicin and Hypofractionated Radiotherapy in Neoadjuvant Sarcoma Treatment
Prospective phase II study. Patients will be submitted to neoadjuvant chemotherapy (cT) and hypo fractionated radiotherapy (hRT) following by surgery.
- Trial name
- NCT02812654
- Testing
- Doxorubicin, Ifosfamide, radiotherapy
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- AC Camargo Cancer Center
Lymphocyte-Rich Classical Hodgkin Lymphoma, Recurrent Lymphocyte-Depleted Classical Hodgkin Lymphoma
Pembrolizumab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
The purpose of this research study is to evaluate a new drug Pembrolizumab in combination with chemotherapy, for Relapsed/Refractory Hodgkin Lymphoma.
- Conditions
- Lymphocyte-Rich Classical Hodgkin Lymphoma, Recurrent Lymphocyte-Depleted Classical Hodgkin Lymphoma, Recurrent Mixed Cellularity Classical Hodgkin Lymphoma, Recurrent Nodular Sclerosis Classical Hodgkin Lymphoma
- Trial name
- NCT03077828
- Testing
- Carboplatin, Etoposide, Ifosfamide
- Where
- 6 sites in United States
- Volunteers
- 43 people
- Sponsor
- Northwestern University
Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Grade 3 Follicular Lymphoma
Oblimersen, Rituximab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma
This phase I/II trial is studying the side effects and best dose of oblimersen when given together with rituximab and combination chemotherapy and to see how well they work in treating patients with relapsed or refractory…
- Conditions
- Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma
- Trial name
- NCT00086944
- Testing
- oblimersen sodium, rituximab, ifosfamide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Soft Tissue Sarcoma
Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma
Phase III, multicenter, randomized open-label and comparative study designed to demonstrate whether adding 4 cycles of peri-operative doxorubicin-based chemotherapy improves metastasis-free survival as compared with standard…
- Trial name
- CHIC-STS01 (NCT04307277)
- Testing
- Standard of care + chemotherapy, Standard of care
- Where
- 20 sites in France
- Volunteers
- 600 people
- Sponsor
- Institut Claudius Regaud
Osteosarcoma of Pelvis
Timing of Surgery in Nonmetastatic Osteosarcoma of the Pelvis and Sacrum
To study the effect of the timing of surgery on outcome of patients with nonmetastatic osteosarcoma of pelvis and sacrum.
- Trial name
- NCT03360760
- Testing
- Doxorubicin, Cisplatin, Methotrexate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Sarcoma
Chemotherapy Plus Radiation Therapy Followed by Surgery in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002791
- Testing
- filgrastim, dacarbazine, doxorubicin hydrochloride
- Where
- 237 sites in United States, Canada and 1 more
- Sponsor
- Radiation Therapy Oncology Group
Advanced Cancer
Phase 1 Study of ZIO-201-T in Combination With Doxorubicin in Solid Tumors
The study of safety of ZIO-201-T in combination with doxorubicin in the treatment of advanced cancer.
- Trial name
- NCT00608803
- Testing
- ZIO-201-T and doxorubicin
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Alaunos Therapeutics
Sarcoma
Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- OS2006 (NCT00470223)
- Testing
- cisplatin, doxorubicin hydrochloride, etoposide
- Where
- 37 sites in France
- Volunteers
- 318 people
- Sponsor
- UNICANCER
Lymphoma
Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002524
- Testing
- Bleomycin Sulfate, Filgrastim, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer
Surgery With or Without Preoperative Chemotherapy in Treating Patients With Resectable Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if surgery is more effective with or without preoperative chemotherapy in treating…
- Trial name
- NCT00003159
- Testing
- carboplatin, cisplatin, docetaxel
- Where
- 2 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- Medical Research Council
Lymphoma
Dose-Dense Therapy in Aggressive Lymphoma
To investigate if a dose-dense chemotherapy with weekly chemotherapy compared to standard treatment every 3 weeks results in better survival in aggressive non-Hodgkin's lymphoma.
- Trial name
- NCT00517894
- Testing
- CEOP/IMVP-Dexa chemotherapy
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Solid Tumor
Ablative Therapy of Oligometastatic Tumor After Response to Conventional First Line Treatment
Advancements in systemic antineoplastic therapies have led to improved overall survival rates for many solid tumors. However, metastatic disease remains a significant challenge and remains the leading cause of mortality for these…
- Trial name
- ATOM-1st (NCT07545486)
- Testing
- Data extraction from medical files
- Where
- 12 sites in Belgium, Cyprus and 3 more
- Volunteers
- 1,235 people
- Sponsor
- Chirec
Sarcoma, Oral Mucositis
Caphosol in Sarcoma Patients With Mucositis
The goal of this clinical research study is to find out if Caphosol® (calcium phosphate) mouthwash is more effective than a baking soda solution at preventing and treating mucositis, in patients with sarcoma who are to be treated…
- Trial name
- NCT00965172
- Testing
- Caphosol, Baking Soda
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Leukemia
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002532
- Testing
- filgrastim, asparaginase, cytarabine
- Where
- Germany
- Sponsor
- Hannover Medical School
Intracranial Germ Cell CNS Tumor, Childhood
The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ Cell Tumors
Primary endpoint 1. three-year disease-free survival of patients with localized basal ganglia germ cell tumors receiving whole-ventricle irradiation 2.
- Trial name
- NCT05124951
- Testing
- Whole-ventricle irradiation, Carboplatin/etoposide, Ifosfamide/cisplatin/etoposide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Pleuropulmonary Blastoma
Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma
This phase III trial tests how well surgery plus chemotherapy compared to surgery alone works in treating patients with type I pleuropulmonary blastoma (PPB), and tests how well surgery plus standard chemotherapy with the…
- Trial name
- NCT06647953
- Testing
- Biospecimen Collection, Bone Scan, Computed Tomography
- Where
- 87 sites in United States, Canada
- Volunteers
- 110 people
- Sponsor
- Children's Oncology Group
Metastatic, Locally Advanced or Unresectable Soft Tissue Sarcoma
Phase 3 Study to Treat Patients With Soft Tissue Sarcomas
The purpose of this study is to determine the efficacy and safety of aldoxorubicin in subjects with metastatic, locally advanced, or unresectable soft tissue sarcomas.
- Trial name
- NCT02049905
- Testing
- Aldoxorubicin, Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide)
- Where
- 74 sites in United States, Australia and 11 more
- Volunteers
- 433 people
- Sponsor
- ImmunityBio, Inc.