Clinical trials: neoadjuvant therapy, completed
Breast Cancer
Prospective Evaluation of Targeted Axillary Dissection (TAD)
The purpose of this research is to evaluate how to manage the axillary lymph nodes in patients with breast cancer. The investigators will determine if a sampling of the lymph nodes under the arm will give the information…
- Trial name
- TAD (NCT04998682)
- Testing
- Axillary Dissection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Treatment Related Cancer
FOLFIRI + Cetuximab + Avelumab RAS Wild-type CRC
Within the proposed single arm multicenter phase-II trial it is intended to investigate the feasi-bility of adding Avelumab to FOLFIRI plus Cetuximab after 4 cycles (2 months) of treatment with FOLFIRI plus Cetuximab.
- Trial name
- NCT05217069
- Testing
- 5-FU, Folinic Acid, Irinotecan
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Breast Cancer
Ultrasound and Chemotherapy of Breast Cancer: Relationship Between Early Vascular Changes of the Tumor and Late Tumoral Response
This study intends to assess the ability of contrast-enhanced ultrasound to make the efficacy of chemotherapy in breast cancer precise.
- Trial name
- NCT00245869
- Testing
- Contrast-enhanced Ultrasound
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Renal Transplant Rejection
Induction Therapy With Autologous Mesenchymal Stem Cells for Kidney Allografts
The goal of this study is to evaluate autologous MSCs as an alternative for antibody induction therapy in renal transplantation.
- Trial name
- NCT00658073
- Testing
- Kidney transplantation with MSCs infusion, kidney transplantation without MSC infusion
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Fuzhou General Hospital
EUS-FNA, Rectal Cancer
TRUS-FNA For The Prediction Of pCR After Neoadjuvant Treatment In Rectal Cancer
Colorectal cancer is one of the most malignancies worldwide. The dominant clinical research strategy of LARC includes neoadjuvant chemoradiotherapy before radical surgery followed combined with adjuvant treatment.
- Conditions
- EUS-FNA, Rectal Cancer, Pathological Complete Remission
- Trial name
- NCT04939103
- Testing
- TRUS-FNA
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Breast Cancer
Premarking of Axillary Nodes Before Start of Neoadjuvant Chemotherapy Using Magnetic Approach
Breast cancer is one of the commonest types of cancers in females. Treatments include surgery followed by anti-estrogen therapy, radiotherapy and chemotherapy.
- Trial name
- SENTINEO (NCT05625698)
- Testing
- MagTrace only, MagTrace and Magseed
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Prostate Cancer, Bladder Cancer
Assessing Financial Toxicity Using the PROFFIT Questionnaire in Patients Treated With Mini-invasive Approach for Urological Malignancies.
Patients previously treated with robotic surgery for urological cancers such as prostate, bladder and kidney cancer will be enrolled, in particular patients operated in the last twelve months will be included after signing the…
- Conditions
- Prostate Cancer, Bladder Cancer, Kidney Cancer
- Trial name
- NCT06955910
- Testing
- questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Locally Advanced Rectal Cancer
Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer
This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced rectal cancer
- Trial name
- NCT03443661
- Testing
- FOLFOXIRI
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Aiping Zhou
Breast Cancer
Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer Patients
This study aimed to compare detection rate between dual sentinel node staining method using mixture of indocyanine green (ICG) with radioisotope(RI), and RI only.
- Trial name
- NCT02479997
- Testing
- Indocyanine green, Radioisotope
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- National Cancer Center, Korea
Lung Cancer
Preoperative Therapy in Patients With Stages IB, II, IIIA, and Selected IIIB Patients With Non-Small Cell Lung Cancer
This trial is designed to study the role of docetaxel/gemcitabine, an active and relatively non-toxic combination in advanced NSCLC.
- Trial name
- NCT00193427
- Testing
- Docetaxel, Gemcitabine, Carboplatin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- SCRI Development Innovations, LLC
High-Grade Lymphomas
HDS Plus PBPC Transplant Vs 4 More Courses of FrontLine Therapy in Pts With Aggressive NHL in PR After Induction Therapy
The study is planned to compare the outcome of aggressive NHL patients in partial remission after four courses of front-line therapy, randomly assigned to receive either additional four courses of the same regimen or a modified…
- Trial name
- NCT00866203
- Testing
- HDS vs ProMECE/CytaBOM
- Where
- Italy
- Volunteers
- 441 people
- Sponsor
- Gruppo Italiano Studio Linfomi
Breast Cancer
Neoadjuvant Chemotherapy Including Sorafenib in Women With Previously Untreated Primary Breast Cancer
The purpose of this study is to determine the efficacy and safety of sorafenib in the neoadjuvant setting in patients with primary breast cancer
- Trial name
- SOFIA (NCT00548899)
- Testing
- Nexavar (Sorafenib)
- Where
- 9 sites in Germany
- Volunteers
- 36 people
- Sponsor
- GBG Forschungs GmbH
Breast Cancer
Cisplatin vs. Doxorubicin/Cyclophosphamide in BrCa
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug, which is cisplatin in this trial, to learn how well it works in treating a specific cancer.
- Trial name
- NCT01670500
- Testing
- Cisplatin, Cyclophosphamide, Doxorubicin
- Where
- 15 sites in United States
- Volunteers
- 118 people
- Sponsor
- Beth Israel Deaconess Medical Center
Nutritional Deficiency, Breast Cancer
Tolerance to Immunomodulatory Nutritional Therapy in Oncology Patients Undergoing Chemotherapy and Radiotherapy
The importance of nutritional support is established in some types of neoplasms, especially those involving the digestive tract.
- Conditions
- Nutritional Deficiency, Breast Cancer, Anal Cancer
- Trial name
- NESTLE (NCT07021378)
- Testing
- Dietary Supplement, Control Cohort A, Control cohort B
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- D'Or Institute for Research and Education
Hepatocellular Carcinoma
SECOX as Neoadjuvant Therapy in Patients With Locally Advanced HCC
The purpose of this study is to evaluate the resectability after treatment with SECOX (sorafenib, capecitabine, oxaliplatin) as neoadjuvant therapy in patients with locally advanced hepatocellular carcinoma
- Trial name
- NCT03578874
- Testing
- Sorafenib, Capecitabine, Oxaliplatin
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- The University of Hong Kong
Adult Giant Cell Glioblastoma, Adult Glioblastoma
Tipifarnib and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Phase II trial to study the effectiveness of combining tipifarnib with radiation therapy in treating patients who have newly diagnosed glioblastoma multiforme.
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
- Trial name
- NCT00058097
- Testing
- tipifarnib, radiation therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Radiation Therapy With or Without Bicalutamide and Goserelin in Treating Patients With Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation therapy in different ways may cause less damage to normal tissue and may improve quality of life and help patients live more…
- Trial name
- NCT00067015
- Testing
- bicalutamide, goserelin acetate, assessment of therapy complications
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
This randomized phase III trial is studying dexamethasone to see how well it works compared to prednisone during induction therapy.
- Conditions
- Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia
- Trial name
- NCT00075725
- Testing
- Cyclophosphamide, Cytarabine, Daunorubicin Hydrochloride
- Where
- 234 sites in United States, Australia and 3 more
- Volunteers
- 3,154 people
- Sponsor
- Children's Oncology Group
Breast Carcinoma
The Relationship Between the Density of Cancer-Associated Fibroblasts in the Peritumoral Stroma and Clinicopathological Data in Breast Cancer Patients
Research Question: Is there a relationship between the clinical prognosis and pathological data of breast cancer patients and the density of cancer-associated fibroblasts in the peritumoral stroma? Objectives of the Study: 1.
- Trial name
- PERICAFS (NCT06666517)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Immunohistochemistry Analysis, Second Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Circulating Tumor Cells
Investigation of Circulating Tumor Cells From Cancer Patients Undergoing Radiation Therapy
The purpose of this study is to investigate the level of Circulating Tumor Cells (CTCs) in cancer patients before and after undergoing treatment regimens where the primary treatment modality is radiation therapy (XRT).
- Trial name
- NCT02449837
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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